Ionic mechanisms of regional action potential heterogeneity in the canine right atrium

Circulation Research

Volumn 83, Issue 5, 1998, Pages 541-551

  Feng, Jianlin ^a   Yue, Lixia ^a,c   Wang, Zhiguo ^a,b   Nattel, Stanley ^a,b,c  

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Action potential duration; Atrial fibrillation; Cardiac arrhythmia; Ion channel; Regional heterogeneity

Indexed keywords

CALCIUM ION; ION CHANNEL; POTASSIUM ION;

ANIMAL CELL; ARRHYTHMOGENESIS; ARTICLE; CALCIUM CURRENT; DOG; FEMALE; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART MUSCLE POTENTIAL; HEART RIGHT ATRIUM; MALE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL;

EID: 0032494146     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.83.5.541     Document Type: Article

References (48)

1. Moe GK, Rheinboldt WC, Abildskov JA. A computer model of atrial fibrillation. Am Heart J. 1964;67:200-220.
2. Sato S, Yamauchi S, Schuessler RB, Boineau JP, Matsunaga Y, Cox JL. The effect of augmented atrial hypothermia on atrial refractory period, conduction, and atrial flutter/fibrillation in the canine heart. J Thorac Cardiovasc Surg. 1992;104:297-306.
3. Wang Z, Nattel S. Idiopathic atrial fibrillation in dogs: underlying electrophysiologic determinants and mechanism of antiarrhythmic action of flecainide. J Am Coll Cardiol. 1995;26:277-286.
4. Wang J, Liu L, Feng J, Nattel S. Regional and functional factors determining the induction and maintenance of atrial fibrillation in dogs. Am J Physiol. 1996;271:H148-H158.
5. Liu L, Nattel S. Differing sympathetic and vagal effects on atrial fibrillation in dogs: role of refractoriness heterogeneity. Am J Physiol. 1997; 273:H805-H816.
6. Gaspo R, Bosch RF, Talajic M, Nattel S. Functional mechanisms underlying tachycardia-induced sustained atrial fibrillation in a chronic dog model. Circulation. 1997;96:4027-4035.
7. Boutjdir M, Le Heuzey JY, Lavergne T, Chauvaud S, Guize L, Carpentier A, Peronneau P. Inhomogeneity of cellular refractoriness in human atrium: factor of arrhythmia? Pacing Clin Electrophysiol. 1986;9: 1095-1100.
8. Ramdat Misier AR, Opthof T, van Hemel NM, Defauw JJAM, de Bakker JMT, Janse MJ, van Capelle FJL. Increased dispersion of "refractoriness" in patients with idiopathic paroxysmal atrial fibrillation. J Am Coll Cardiol. 1992;19:1531-1535.
9. Hogan PM, Davis LD. Evidence for specialized fibers in the canine right atrium. Circ Res. 1968;23:387-396.
10. Spach MS, Dolber PC, Anderson PAW. Multiple regional differences in cellular properties that regulate repolarization and contraction in the right atrium of adult and newborn dogs. Circ Res. 1989:65:1594-1611.
11. Qi A, Yeung-Lai-Wah JA, Xiao J, Kerr CR. Regional differences in rabbit atrial repolarization: importance of transient outward current. Am J Physiol. 1994;266:H643-H649.
12. Yamashita T, Nakajima T, Hazama H, Hamada E, Murakawa Y, Sawada K, Omata M. Regional differences in transient outward current density and inhomogeneities of repolarization in rabbit right atrium. Circulation. 1995;92:3061-3069.
13. Restivo M, Hegazy M, El-Hamamy M, Yin H, Caref EB, Assadi MA, Zhang S, Brooks RR, El-Sherif N. Preferential prolongation of refractoriness in the lower right atrium by the class III agent dofetilide: target for antiarrhythmic action in two models of functional circus movement atrial flutter [abstract]. Pacing Clin Electrophysiol. 1996;19(pt II):684.
14. + channel mRNA in isolated ferret cardiac myocytes. Circ Res. 1996;78: 1083-1089.
15. Yue L, Feng J, Li GR, Nattel S. Transient outward and delayed rectifier currents in canine atrium: properties and role of isolation methods. Am J Physiol. 1996;270:H2157-H2168.
16. Yue L, Feng J, Li GR, Nattel S. Characterization of an ultrarapid delayed rectifier potassium channel involved in canine atrial repolarization. J Physiol (Lond). 1996;496:647-662.
17. Yue L, Feng J, Gaspo R, Li G-R, Wang Z, Nattel S. Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ Res. 1997;81:512-525.
18. Ca at physiological temperatures and relevance to action potential. Am J Physiol. 1997;272:H227-H235.
19. Sun H, Leblanc N, Nattel S. Mechanisms of inactivation of L-type calcium channels in human atrial myocytes. Am J Physiol. 1997;272: H1625-H1635.
20. Antzelevitch C, Sicouri S, Litovsky SH. Lukas A, Krishnan SC, Di Diego JM, Gintant GA, Liu DW. Heterogeneity within the ventricular wall: electrophysiology and pharmacology of epicardial, endocardial, and M cells. Circ Res. 1991;69:1427-1449.
21. Litovsky SH, Antzelevitch C. Transient outward current prominent in canine ventricular epicardium but not endocardium. Circ Res. 1988;62: 116-126.
22. Sicouri S, Antzelevitch C. A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle: the M cell. Circ Res. 1991;68:1729-1741.
23. Sicouri S, Quist M, Antzelevitch C. Evidence for the presence of M cells in the guinea pig ventricle. J Cardiovasc Electrophysiol. 1996;7:503-511.
24. Bridge JH, Caben WR Jr, Langer GA, Reeder S. Sodium efflux in rabbit myocardium: relationship to sodium-calcium exchange. J Physiol (Lond). 1981;316:555-574.
25. Fedida D, Giles WR. Regional variations in action potentials and transient outward current in myocytes isolated from rabbit left ventricle. J Physiol (Lond). 1991;442:191-209.
26. Drouin E, Charpentier F, Gauthier C, Laurent K, Le Marec H. Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: evidence for presence of M cells. J Am Coll Cardiol. 1995;26:185-192.
27. Li GR, Feng J, Carrier M, Nattel S. Transmural electrophysiologic heterogeneity in the human ventricle [abstract]. Circulation. 1995;92(suppl I):I-158.
28. Liu DW, Gintant GA, Antzelevitch C. Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circ Res. 1993;72:671-687.
29. Ks contributes to the longer action potential of the M cell. Circ Res. 1995;76:351-365.
30. K,s in electrical heterogeneity. Am J Physiol 1995;268:H604-H613.
31. Litovsky SH, Antzelevitch C. Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: role of the transient outward current. J Am Coll Cardiol. 1989;14:1053-1066.
32. Yan GX, Antzelevitch C. Cellular basis for the electrocardiographic J wave. Circulation. 1996;93:372-379.
33. Sicouri S, Antzelevitch C. Drug-induced after depolarizations and triggered activity occur in a discrete subpopulation of ventricular muscle cells (M cells) in the canine heart: quinidine and digitalis. J Cardiovasc Electrophysiol. 1993;4:48-58.
34. Krishnan SC, Antzelevitch C. Sodium channel block produces opposite electrophysiological effects in canine ventricular epicardium and endocardium. Circ Res. 1991;69:277-291.
35. Di Diego JM, Antzelevitch C. Pinacidil-induced electrical heterogeneity and extrasystolic activity in canine ventricular tissues: does activation of ATP-regulated potassium current promote phase 2 reentry? Circulation. 1993;88:1177-1189.
36. Lukas A, Antzelevitch C. Differences in the electrophysiological response of canine ventricular epicardium and endocardium to ischemia: role of the transient outward current. Circulation. 1993;88:2903-2915.
37. 0-induced electrical heterogeneity and extrasystolic activity in isolated canine ventricular epicardium: phase 2 reentry. Circulation. 1994;89:1839-1850.
38. Dixon JE, McKinnon D. Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats. Circ Res. 1994;75:252-260.
39. Giles WR, van Ginneken ACG. A transient outward current in isolated cells from the crista terminalis of rabbit heart. J Physiol (Lond). 1985; 368:243-264.
40. Giles WR, Imaizumi Y. Comparison of potassium currents in rabbit atrial and ventricular cells. J Physiol (Lond). 1988;405:123-145.
41. Nattel S, Bourne G, Talajic M. Insights into mechanisms of antiarrhythmic drug action from experimental models of atrial fibrillation. J Cardiovasc Electrophysiol. 1997;8:469-480.
42. Cha Y, Wales A, Wolf P, Shahrokni S, Sawhney N, Feld GK. Electrophysiologic effects of the new class III antiarrhythmic drug dofetilide compared to the class IA antiarrhythmic drug quinidine in experimental canine atrial flutter: role of dispersion of refractoriness in antiarrhythmic efficacy. J Cardiovasc Electrophysiol. 1996;7:809-827.
43. Wang Z, Fermini B, Nattel S. Delayed rectifier outward current and repolarization in human atrial myocytes. Circ Res. 1993;73:276-285.
44. Spach MS, Dolber PC, Heidlage JF. Interaction of inhomogeneities of repolarization with anisotropic propagation in dog atria: a mechanism for both preventing and initiating reentry. Circ Res. 1989;65: 1612-1631.
45. + current, in the ferret heart. Circ Res. 1997;81: 128-135.
46. Nishimura M, Habuchi Y, Hiromasa S, Watanabe Y. Ionic basis of depressed automaticity and conduction by acetylcholine in rabbit AV node. Am J Physiol. 1988;255:H7-H14.
47. Alessi R, Nusynowitz M, Abildskov JA, Moe GK. Nonuniform distribution of vagal effects on the atrial refractory period. Am J Physiol. 1958;194:406-410.
48. Ninomiya I. Direct evidence of nonuniform distribution of vagal effects on dog atria. Circ Res. 1966;19:576-583.