Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 14, 2012, Pages 4217-4225

  Gangjee, Aleem ^a   Zhao, Ying ^a   Ihnat, Michael A ^b   Thorpe, Jessica E ^b   Bailey Downs, Lora C ^b   Kisliuk, Roy L ^c  

^a DUQUESNE UNIVERSITY   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antiangiogenic agents; Antitumor agents; Indeno 2,1 d pyrimidines; Receptor tyrosine kinase inhibitors

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; ANTINEOPLASTIC AGENT; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; INDENOL (2,1 D) PYRIMIDINE DERIVATIVE; METHOTREXATE; N4 (2 ISOPROPYLPHENYL) 9H INDENO[2,1 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 BROMOPHENYL) 9H INDENO[2,1 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 CHLORO 4 FLUOROPHENYL) 9H INDENO[2,1 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 CHLOROPHENYL) 9H INDENO[2,1 D] PYRIMIDINE 2,4 DIAMINE; N4 (3 FLUOROPHENYL) 9H INDENO[2,1 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 METHOXYMETHYL) 9H INDENO[2,1 D]PYRIMIDINE 2,4 DIAMINE; N4 (3 METHOXYPHENYL) 9H INDENO[2,1 D]PYRIMIDINE 2,4 DIAMINE; N4 (4 BROMOPHENYL) 9H INDENO[2,1 D]PYRIMIDINE 2,4 DIAMINE; N4 (4 CHLORO 2 FLUOROPHENYL) 9H INDENO[2,1 D]PYRIMIDINE 2,4 DIAMINE; N4 (4 CHLOROPHENYL) 9H INDENO[2,1 D] PYRIMIDINE 2,4 DIAMINE; N4 (4 FLUOROPHENYL) 9H INDENO[2,1 D]PYRIMIDINE 2,4 DIAMINE; N4 (4 ISOPROPYLPHENYL) 9H INDENO[2,1 D]PYRIMIDINE 2,4 DIAMINE; N4 [4 (TRIFLUOROMETHYL)PHENYL] 9H INDENO[2,1 D]PYRIMIDINE 2,4 DIAMINE; N4 PHENYL 9H INDENO[2,1 D]PYRIMIDINE 2,4 DIAMINE; PEMETREXED; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PYRIMETHAMINE; PYRIMIDINE DERIVATIVE; RALTITREXED; SEMAXANIB; SU 4312; SUNITINIB; TRIMETHOPRIM; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CHICK EMBRYO; CHORIOALLANTONIC MEMBRANE; CYCLOCONDENSATION; DIECKMANN REACTION; DISEASE MODEL; DRUG DESIGN; DRUG DETERMINATION; DRUG SYNTHESIS; EMBRYO; EMBRYONIC STRUCTURES; MELANOMA; MOUSE; NONHUMAN; SUBSTITUTION REACTION; SULFONATION; TUMOR CELL LINE;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHICK EMBRYO; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDENES; MELANOMA, EXPERIMENTAL; MICE; PYRIMIDINES; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA;

EID: 84863222732     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.068     Document Type: Article

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