Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl- 7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 14, 2010, Pages 5261-5273

  Gangjee, Aleem ^a   Zhao, Ying ^a   Raghavan, Sudhir ^a   Ihnat, Michael A ^b   Disch, Bryan C ^b  

^a DUQUESNE UNIVERSITY   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Antiangiogenic agents; Multiple receptor; Tyrosine kinase inhibitors

Indexed keywords

2 AMINO 4 (3 BROMOANILINO) 6 (2 METHYLBENZYL) 7 METHYLPYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (3 BROMOANILINO) 6 (2,5 DIMETHOXYBENZYL) 7 METHYLPYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (3 BROMOANILINO) 6 BENZYL 7 METHYLPYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (N METHYL 3 BROMOANILINO) 6 (2 METHYLBENZYL) 7 METHYLPYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (N METHYL 3 BROMOANILINO) 6 (2 METHYLBENZYL)PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (N METHYL 3 BROMOANILINO) 6 (2,5 DIMETHOXYBENZYL) 7 METHYLPYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (N METHYL 3 BROMOANILINO) 6 (2,5 DIMETHOXYBENZYL)PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (N METHYL 3 BROMOANILINO) 6 BENZYL 7 METHYLPYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (N METHYL 3 BROMOANILINO) 6 BENZYLPYRROLO[2,3 D]PYRIMIDINE; ANGIOGENESIS INHIBITOR; ANILINE DERIVATIVE; BROMINE DERIVATIVE; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; METHYL GROUP; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; SEMAXANIB; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ARTICLE; CHLORINATION; CONTROLLED STUDY; CYCLIZATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; METHYLATION; MOLECULAR DOCKING; MOLECULAR INTERACTION; RECEPTOR DOWN REGULATION; WHOLE CELL;

ANGIOGENESIS INHIBITORS; CELL LINE, TUMOR; HUMANS; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 77955338644     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.05.049     Document Type: Article

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