KSHV gene expression and regulation

Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis

Volumn , Issue , 2007, Pages 490-513

  Schulz, Thomas F ^a   Chang, Yuan ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84863197950     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511545313.029     Document Type: Chapter

References (141)

1. AuCoin, D. P. and Pari, G. S. (2002). The human herpesvirus-8 (Kaposi's sarcoma-associated herpesvirus) ORF 40/41 region encodes two distinct transcripts. J. Gen. Virol., 83, 189-193.
2. Bechtel, J. T., Liang, Y., Hvidding, J., and Ganem, D. (2003). Host range of Kaposi's sarcoma-associated herpesvirus in cultured cells. J. Virol., 77, 6474-6481.
3. Bello, L. J., Davison, A. J., Glenn, M. A. et al. (1999). The human herpesvirus-8 ORF 57 gene and its properties. J. Gen. Virol., 80 (12), 3207-3215.
4. Bieleski, L. and Talbot, S. J. (2001). Kaposi's sarcoma-associated herpesvirus vCYClin open reading frame contains an internal ribosome entry site. J. Virol., 75, 1864-1869.
5. Birkmann, A., Mahr, K., Ensser, A., Yaguboglu, S., Titgemeyer, F., Fleckenstein, B., and Neipel, F. (2001). Cell surface hep-aran sulfate is a receptor for human herpesvirus 8 and inter-acts with envelope glycoprotein K8.1. J. Virol., 75, 11583-11593.
6. Bowser, B. S., DeWire, S. M., and Damania, B. (2002). Transcrip-tional regulation of the K1 gene product of Kaposi's sarcoma-associated herpesvirus. J. Virol., 76, 12574-12583.
7. Brinkmann, M. M., Glenn, M., Rainbow, L., Kieser, A., Henke-Gendo, C., and Schulz, T. F. (2003). Activation of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane pro-tein. J. Virol., 77, 9346-9358.
8. Cai, S., Lu, S., Zhang, Z., Gonzalez, C. M., Damania, B., Cullen, B. R. (2005). Kaposi's sarcoma-associated herpesvirus ex-presses an array of viral micrRNAs in latently infected cells. Proc. Natl. Acad. Sci. USA, 102, 5570-5575.
9. Cai, X. and Cullen, B. R. (2006). Transcriptional origin of Kaposi's sarcoma-associated herpesvirus micrRNAs. J. Virol., 80, 2234-2242.
10. Cai, X., Lu, S., Zhang, Z., Gonzalez, C. M., Damania, B., and Cullen, B. R. (2005). Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc. Natl Acad. Sci. USA, 102, 5570-5575.
11. Canham, M. and Talbot, S. J. (2004). A naturally occurring c-terminal truncated isoform of the latent nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus (KSHV) does not associate with viral episomal DNA. J. Gen. Virol., 85, in press.
12. Cannon, J. S., Nicholas, J., Orenstein, J. M. et al. (1999). Hetero-geneity of viral IL-6 expression in HHV-8-associated diseases. J. Infect. Dis., 180, 824-828.
13. Chandran, B., Bloomer, C., Chan, S. R., Zhu, L., Goldstein, E., and Horvat, R. (1998). Human herpesvirus-8 ORF K8.1 gene encodes immunogenic glycoproteins generated by spliced transcripts. Virology, 249, 140-149.
14. Chang, H., Dittmer, D. P., Chul, S-Y., Hong, Y., and Jung, J. U. (2006). Role of notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expression. J. Virol., 79, 14371-14382.
15. Chang, J., Renne, R., Dittmer, D. et al. (2000). In?ammatory cyto-kenes and the reactivation of Kaposi's sarcoma-associated her-pesvirus lytic replication. Virology, 266, 17-25.
16. Chang, P. J., Shedd, D., Gradoville, L. et al. (2002). Open reading frame 50 protein of Kaposi's sarcoma-associated herpesvirus directly activates the viral PAN and K12 genes by binding to related response elements. J. Virol., 76, 3168-3178.
17. Chatterjee, M., Osborne, J., Bestetti, G., Chang, Y., and Moore, P. S. (2002). Viral IL-6-induced cell proliferation and immune eva-sion of interferon activity. Science, 298, 1432-1435.
18. Chen, L. and Lagunoff, M. (2005). Establishment and maintenance of Kaposi's sarcoma-associated herpesvirus latency in B cells. J. Virol., 79, 14383-14391.
19. Chen, J., Ueda, K., Sakakibara, S., Okuno, T., and Yamanishi, K. (2000). Transcriptional regulation of the Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor gene. J. Virol., 74, 8623-8634.
20. Chen, J., Ueda, K., Sakakibara, S. et al. (2001). Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator. Proc. Natl Acad. Sci. USA, 98(7), 4119-4124.
21. Chiou, C. J., Poole, L. J., Kim, P. S. et al. (2002). Patterns of gene expression and a transactivation function exhibited by the vGCR (ORF 74) chemokine receptor protein of Kaposi's sarcoma-associated herpesvirus. J. Virol., 76, 3421-3439.
22. Choi, J. K., Lee, B. S., Shim, S. N. et al. (2000). Identifications of the novel K15 gene at the rightmost end of the Kaposi's sarcoma-associated herpesvirus genome. J. Virol., 74, 436-446.
23. Ciufo, D. M., Cannon, J. S., Poole, L. J. et al. (2001). Spindle cell con-version by Kaposi's sarcoma-associated herpesvirus: Forma-tion of colonies and plaques with mixed lytic and latent gene expressionininfectedprimarydermalmicrovascular endothe-lial cell cultures. J. Virol., 75, 5614-5626.
24. Cook, P. M., Whitby, D., Calabro, M. L. et al. (1999). Variability and evolution of Kaposi's sarcoma-associated herpesvirus in Europe and Africa. International Collaborative Group. AIDS, 13, 1165-1176.
25. Coscoy, L. and Ganem, D. (2000). Kaposi's sarcoma-associated her-pesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis. Proc. Natl Acad. Sci. USA, 97, 8051-8056.
26. Cunningham, C., Barnard, S., Blackbourn, D. J., and Davison, A. J. (2003). Transcription mapping of human herpesvirus 8 genes encoding viral interferon regulatory factors. J. Gen. Virol., 84, 1471-1483.
27. Davis, D. A., Rinderknecht, A. S., Zoeteweij, J. P. et al. (2001). Hypoxia induces lytic replication of Kaposi sarcoma-associated her-pesvirus. Blood, 97, 3244-3250.
28. Deng, H., Young, A., and Sun, R. (2000). Auto-activation of the rta geneofhuman herpesvirus-8/Kaposi's sarcoma-associated herpesvirus. J. Gen. Virol., 81, 3043-3048.
29. Deng, H., Chu, J. T., Rettig, M. B., Martinez-Maza, O., and Sun, R. (2002). Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression. Blood, 100, 1919-1921.
30. Dezube, B. J., Zambela, M., Sage, D. R., Wang, J. F., and Fingeroth, J. D. (2002). Characterization of Kaposi sarcoma-associated her-pesvirus/human herpesvirus-8 infection of human vascular endothelial cells: Early events. Blood, 100, 888-896.
31. Dittmer, D. P. (2003). Transcription pro?le of Kaposi's sarcoma-associated herpesvirus in primary Kaposi's sarcoma lesions as determined by real-time PCR arrays. Cancer Res., 63, 2010-2015.
32. Dittmer, D., Lagunoff, M., Renne, R. et al. (1998). A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus. J. Virol., 72, 8309-8315.
33. Dupin, N., Fisher, C., Kellam, P. et al. (1999). Distribution of human herpesvirus-8 latently infected cells in Kaposi's sar-coma, multicentric Castleman's disease, and primary effusion lymphoma. Proc. Natl Acad. Sci. USA, 96, 4546-4551.
34. Ensoli, B., Sturzl, M., and Monini, P. (2001). Reactivation and role of HHV-8 in Kaposi's sarcoma initiation. Adv. Cancer Res., 81, 161-200.
35. Fakhari, F. D. and Dittmer, D. P. (2002). Charting latency transcripts in Kaposi's sarcoma-associated herpesvirus by whole-genome real-time quantitative PCR. J. Virol., 76, 6213-6223.
36. Gao, S. J., Boshoff, C., Jayachandra, S., Weiss, R. A., Chang, Y., and Moore, P. S. (1997). KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway. Oncogene, 15, 1979-1985.
37. Gao, S. J., Deng, J. H., and Zhou, F. C. (2003). Productive lytic replication of a recombinant Kaposi's sarcoma-associated her-pesvirus in ef?cient primary infection of primary human endothelial cells. J. Virol., 77, 9738-9749.
38. Glenn, M., Rainbow, L., Aurade, F., Davison, A., and Schulz, T. F. (1999). Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus. J. Virol., 73, 6953-6963.
39. Gradoville, L., Geralach, J., Grogan, E. et al. (2000). Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1. J. Gen. Virol., 80(3), 557-561.
40. Gruffat, H., Portes-Sentis, S., Sergeant, A., and Manet, E. (1999). Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1. J. Gen. Virol., 80(3), 557-561.
41. Grundhoff, A. and Ganem, D. (2001). Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus. J. Virol., 75, 1857-1863.
42. Grundhoff, A., Sullivan, C. S., and Ganem, D. (2006). A combined computational and microarray-based approach identi?es novel microRNAs encoded by human gamma-herpesviruses. RNA, 12, 733-750.
43. Haque, M., Chen, J., Ueda, K. et al. (2000). Identification and anal-ysis of the K5 gene of Kaposi's sarcomaassociated herpesvirus. J. Virol., 74, 2867-2875.
44. Haque, M., Ueda, K., Nakano, K. et al. (2001). Major histocompata-bility complex class I molecules are down-regulated at the cell surface by the K5 protein encoded by the Kaposi's sarcoma-associated herpesvirus human herpesvirus-8. J. Gen. Virol., 82, 1175-1180.
45. Haque, M., Davis, D. A., Wang, V., Widmer, I., and Yarchoan, R. (2003). Kaposi's sarcoma-associated herpesvirus (human her-pesvirus 8) contains hypoxia response elements: Relevance to lytic induction by hypoxia. J. Virol., 77, 6761-6768.
46. Harrington, W., Jr., Sieczkowski, L., Sosa, C. et al. (1997). Activation of HHV-8 by HIV-1 tat. Lancet, 349, 774-775.
47. Huang, L. M., Chao, M. F., Chen, M. Y. et al. (2001). Reciprocal reg-ulatory interaction between human herpesvirus 8 and human immunode?ciency virus type 1. J. Biol. Chem., 276, 13427-13432.
48. Inagi, R., Okuno, T., Ito, M. et al. (1999). Identification and charac-terization of human herpesvirus 8 open reading frame K9 viral interferon regulatory factor bya monoclonal antibody. J. Hum. Virol., 2, 63-71.
49. Ishido, S., Choi, J. K., Lee, B. S. et al. (2000). Inhibition of nat-ural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein. Immunity, 13, 365-374.
50. Izumiya, Y., Lin, S. F., Ellison, T. J. et al. (2003a). Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: Direct interaction with cyclin-CDK2 and induction of G1 growth arrest. J. Virol., 77, 9652-9661.
51. Izumiya, Y., Lin, S. F., Ellison, T. et al. (2003b). Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: Physical association and promoterdependent transcriptional repression. J. Virol., 77, 1441-1451.
52. Jenner, R. G., Alba, M. M., Boshoff, C., and Kellam, P. (2001). Kaposi's sarcoma-associated herpesvirus latent and lytic gene expres-sion as revealed by DNA arrays. J. Virol., 75, 891-902.
53. Jeong, J., Papin, J., and Dittmer, D. (2001). Differential regulation of the overlapping Kaposi's sarcomaassociated herpesvirus vGPCR (ORF74) and LANA (ORF73) promoters. J. Virol., 75, 1798-1807.
54. Jeong, J. H., Orvis, J., Kim, J. W. et al. (2004). Regulation and autoreg-ulation of the promoter for the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J. Biol. Chem., 279, 16822-16831.
55. Johnson, A. S., Maronian, N., and Vieira, J. (2005). Activation of Kaposi's sarcoma-associated herpesvirus lytic gene expression during epithelial differentiation. J. Virol., 79, 13769-13777.
56. Katano, H., Sato, Y., Kurata, T., Mori, S., and Sata, T. (1999a). High expression of HHV-8-encoded ORF73 protein in spindle-shaped cells of Kaposi's sarcoma. Am. J. Pathol., 155, 47-52.
57. Katano, H., Sata, T., Suda, T. et al. (1999b). Expression and anti-genicity of human herpesvirus 8 encoded ORF59 protein in AIDS-associated Kaposi's sarcoma. J. Med. Virol., 59, 346-355.
58. Katano, H., Sato, Y., Kurata, T., Mori, S., and Sata, T. (2000). Expres-sion and localization of human herpesvirus 8-encoded pro-teins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease. Virology, 269, 335-344.
59. Katano, H., Sato, Y., Itoh, H., and Sata, T. (2001). Expression of human herpesvirus 8 (HHV-8)-encoded immediate early pro-tein, open reading frame 50, in HHV-8-associated diseases. J. Hum. Virol., 4, 96-102.
60. Kirshner, J. R., Staskus, K., Haase, A., Lagunoff, M., and Ganem, D. (1999). Expression of the open reading frame 74 (G-protein-coupled receptor) gene of Kaposi's sarcoma (KS)-associated herpesvirus: Implications for KS pathogenesis. J. Virol., 73, 6006-6014.
61. Kirshner, J. R., Lukac, D. M., Chang, J., and Ganem, D. (2000). Kaposi's sarcoma-associated herpesvirus open reading frame 57 encodes a posttranscriptional regulator with multiple dis-tinct activities. J. Virol., 74, 3586-3597.
62. Kliche, S., Nagel, W., Kremmer, E. et al. (2001). Signaling by human herpesvirus 8 kaposin A through direct membrane recruitment of cytohesin-1. Mol. Cell, 7, 833-843.
63. Krishnan, H. H., Naranatt, P. P., Smith, M. S. et al. (2004). Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of pri-mary endothelial and ?broblast cells and subsequent decline of lytic gene expression. J. Virol., 78, 2601-2620.
64. Lagunoff, M. and Ganem, D. (1997). The structure and coding organization of the genomic termini of Kaposi's sarcoma-associated herpesvirus. Virology, 236, 147-154.
65. Lagunoff, M., Majeti, R., Weiss, A. et al. (1999). Deregulated sig-nal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Proc. Natl Acad. Sci. USA, 96, 5704-5709.
66. Lagunoff, M., Lukac, D. M., and Ganem, D. (2001). Immunore-ceptor tyrosine-based activation motifdependent signaling by Kaposi's sarcoma-associated herpesvirus K1 protein: Effects on lytic viral replication. J. Virol., 75, 5891-5898.
67. Lagunoff, M., Bechtel, J., Venetsanakos, E. et al. (2002). De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells. J. Virol., 76, 2440-2448.
68. Lee, B. S., Alvarez, X., Ishido, S., Lackner, A. A., and Jung, J. U. (2000). Inhibition of intracellular transport of B cell antigen recep-tor complexes by Kaposi's sarcoma-associated herpesvirus K1. J. Exp. Med., 192, 11-21.
69. Lee, B. S., Paulose-Murphy, M., Chung, Y. H., Connlole, M., Zeichner, S., and Jung, J. U. (2002). Suppression of tetradecanoyl phor-bol acetate-induced lytic reactivation of Kaposi's sarcoma-associated herpesvirus by K1 signal transduction. J. Virol., 76, 12185-12199.
70. Lee, B. S., Connole, M., Tang, Z., Harris, N. L., and Jung, J. U. (2003). Structural analysis of the Kaposi's sarcoma-associated her-pesvirus K1 protein. J. Virol., 77, 8072-8086.
71. Lee, H., Guo, J., Li, M. et al. (1998a). Identification of an immunore-ceptor tyrosine-based activation motif of K1 transforming pro-tein of Kaposi's sarcomaassociated herpesvirus. Mol. Cell Biol., 18, 5219-5228.
72. Lee, H., Veazey, R., Williams, K. et al. (1998b). Deregulation of cell growth by the K1 gene of Kaposi's sarcomaassociated her-pesvirus. Nat. Med., 4, 435-440.
73. Li, H., Komatsu, T., Dezube, B. J., and Kaye, K. M. (2002). The Kaposi's sarcoma-associated herpesvirus K12 transcript from a primary effusion lymphoma contains complex repeat ele-ments, is spliced, and initiates froma novel promoter. J. Virol., 76, 11880-11888.
74. Liang, Y. and Ganem, D. (2003). Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling. Proc. Na Sci. USA, 100, 8490-8495.
75. Ganem, D. (2004). RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA. J. Virol., 78, 6818-6826
76. Ganem, D. (2004). RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA. J. Virol., 78, 6818-6826.
77. Liang, Y., Chang, J., Lynch, S. J., Lukac, D. M., and Ganem, D. (2002). The lytic switch protein of KSHV activates gene expres-sion via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway. Genes Dev., 16, 1977-1989.
78. Lin, S. F., Robinson, D. R., Miller, G., and Kung, H. J. (1999). Kaposi's sarcoma-associated herpesvirus encodes a bZIP protein with homology to BZLF1 of Epstein-Barr virus. J. Virol., 73, 1909-1917.
79. Low, W., Harries, M., Ye, H., Du, M. Q., Boshoff, C., and Collins, M. (2001). Internal ribosome entry site regulates translation of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein. J. Virol., 75, 2938-2945.
80. Lubyova, B. and Pitha, P. M. (2000). Characterization of a novel human herpesvirus 8-encoded protein, vIRF-3, that shows homology to viral and cellular interferon regulatory factors. J. Virol., 74, 8194-8201.
81. Lukac, D. M., Kirshner, J. R., and Ganem, D. (1999). Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reac-tivation inB cells. J. Virol., 73, 9348-9361.
82. Matsumara, S., Fujita, Y., Gomez, E., Tanese, N., and Wilson, A. C. (2005). Activation of the Kaposi's sarcoma-associated herpesvirus major latency locus by the lytic switch protein RTA (ORF50). J. Virol., 79, 8493-8505.
83. Mercader, M., Taddeo, B., Panella, J. R., Chandran, B., Nickoloff, B. J., and Foreman, K. E. (2000). Induction of HHV-8 lytic cycle repli-cation by in?ammatory cytokines produced by HIV-1-infected T cells. Am. J. Pathol., 156, 1961-1971.
84. Monini, P., Colombini, S., Sturzl, M. et al. (1999). Reactivation and persistence of human herpesvirus-8 infection in B cells and monocytes by Th-1 cytokines increased in Kaposi's sarcoma. Blood, 93, 4044-4058.
85. Moses, A. V., Fish, K. N., Ruhl, R. et al. (1999). Long-term infection and transformation of dermal microvascular endothelial cells by human herpesvirus 8. J. Virol., 73, 6892-6902.
86. Mullick, J., Bernet, J., Singh, A. K., Lambris, J. D., and Sahu, A. (2003). Kaposi's sarcoma-associated herpesvirus (human her-pesvirus 8) open reading frame4 protein (kaposica) is a func-tional homolog of complement control proteins. J. Virol., 77, 3878-3881.
87. Nador, R. G., Milligan, L. L., Flore, O. et al. (2001). Expression of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor monocistronic and bicistronic transcripts in primary effusion lymphomas. Virology, 287, 62-70.
88. Nakamura, H., Muller, J. T., Chandrasekhar, S. et al. (2001). Multimodality therapy with a replication-conditional herpes simplex vius mutant that expresses yeast cytosine deami-nase for intranumoral conversion of 5-?uorocytosine to 5-?uorouracil. Cancer Res., 61, 5447-5452.
89. Nakamura, H., Lu, M., Gwack, Y., Souvlis, J., Zeichner, S. L., and Jung, J. U. (2003). Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivator. J. Virol., 77, 4205-4220.
90. Naranatt, P. P., Krishnan, H. H., Svojanovsky, S. R., Bloomer, C., Mathur, S., and Chandran, B. (2004). Host gene induction and transcriptional reprogramming in Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8)-infected endothelial, ?broblast, and B cells: Insights into modulation events early during infection. Cancer Res., 64, 72-84.
91. Neipel, F., Albrecht, J. C., and Fleckenstein, B. (1997). Cell-homologous genes in the Kaposi's sarcomaassociated rhadinovirus human herpesvirus 8: Determinants of its pathogenicity? J. Virol., 71, 4187-4192.
92. Ohare, P. (1993). The virion transactivator of herpes simplex virus. Semin. Virol., 4, 145-155.
93. Parravicini, C., Chandran, B., Corbellino, M. et al. (2000). Differ-ential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infecteddiseases: Kaposi's sarcoma, primary effu-sion lymphoma, and multicentric Castleman's disease. Am. J. Pathol., 156, 743-749.
94. Paulose-Murphy, M., Ha, N. K., Xiang, C. et al. (2001). Transcription program of human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus). J. Virol., 75, 4843-4853.
95. Pearce, M., Matsumara, S., and Wilson, A. C. (2005). Transcripts encoding K12, v-FLIP, v-cyclin, and the microRNA cluster of Kaposi's sarcoma-associated herpesvirus originate from a common promoter. J. Virol., 79, 14457-14464.
96. Pfeffer, S., Sewer, A., Lagos-Quintana, M. et al. (2005). Identification of microRNAs of the herpesvirus family. Nature Methods, 2, 269-276.
97. Polson, A. G., Huang, L., Lukac, D.M. et al. (2001). Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin dependent kinases. J. Virol., 75, 3175-3184.
98. Poole, L. J., Zong, J. C., Ciufo, D. M. et al. (1999). Comparison of genetic variability at multiple loci across the genomes of the major subtypes of Kaposi's sarcoma-associated herpesvirus reveals evidence for recombination and for two distinct types of open reading frame K15 alleles at the right-hand end. J. Virol., 73, 6646-6660.
99. Raab, M. S., Albrecht, J. C., Birkmann, A. et al. (1998). The immuno-genicglycoprotein gp35-37 of human herpesvirus 8isencoded by open reading frame K8.1. J. Virol., 72, 6725-6731.
100. Rainbow, L., Platt, G. M., and Simpson, G. R. (1997). The 222-to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by ORF73 and is a component of the latency-associated nuclear antigen. J. Virol., 71, 5915-5921.
101. Reed, J. A., Nador, R. G., Spaulding, D., Tani, Y., Cesarman, E., and Knowles, D. M. (1998). Demonstration of Kaposi's sarcoma-associated herpes virus cyclin D homolog in cuta-neous Kaposi's sarcoma by colorimetric in situ hybridization using a catalyzed signal ampli?cation system. Blood, 91, 3825-3832.
102. Renne, R., Blackbourn, D., Whitby, D., Levy, J., and Ganem, D. (1998). Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells. J. Virol., 72, 5182-5188.
103. Rimessi, P., Bonaccorsi, A., Sturzl, M. et al. (2001). Transcription pattern of human herpesvirus8 open reading frame K3 in pri-mary effusion lymphoma and Kaposi's sarcoma. J. Virol., 75, 7161-7174.
104. Rivas, C., Thlick, A. E., Parravicini, C., Moore, P. S., and Chang, Y. (2001). Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-speci?c latent viral protein that inhibits p53. J. Virol., 75, 429-438.
105. Roizman, B. and Knipe, D. M. (2001). Herpes Simplex viruses and their replication, p. 2399-2459. In D. M. Knipe and P. Howley, Fields Virology, ed. Lippincott Williams & Wilkins, Philadel-phia.
106. Russo, J. J., Bohenzky, R. A., Chien, M. C. et al. (1996). Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc. Natl Acad. Sci. USA, 93, 14862-14867.
107. Sachsenberg-Struder, E. M., Dobrynski, N., Sheldon, J. et al. (1999). Human herpesvirus S seropositive patient with skin and graft Kaposi's sarcoma after lung transplantation. J. Am. Acad. Der-matol., 40, 308-311.
108. Sadler, R., Wu, L., Forghani, B. et al. (1999). A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus. J. Virol., 73, 5722-5730.
109. Sakakibara, S., Ueda, K., Chen, J., Okuno, T., and Yaman-ishi, K. (2001). Octamer-binding sequence is a key element for the autoregulation of Kaposi's sarcoma-associated her-pesvirus ORF50/Lyta gene expression. J. Virol., 75, 6894-6900.
110. Samols, M. A., Hu, J., Skalsky, R. L., and Renne, R. (2005). Cloning and Identification of a microRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus. J. Virol., 79, 9301-9305.
111. Sarid, R., Flore, O., Bohenzky, R. A., Chang, Y., and Moore, P. S.(1998). Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1). J. Virol., 72, 1005-1012.
112. Sarid, R., Wiezorek, J. S., Moore, P. S., and Chang, Y. (1999). Char-acterization and cell cycle regulation of the major Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) latent genes and their promoter. J. Virol., 73, 1438-1446.
113. Saveliev, A., Zhu, F., and Yuan, Y. (2002). Transcription mapping and expression patterns of genes in the major immediate-early region of Kaposi's sarcoma-associated herpesvirus. Virology, 299, 301-314.
114. Seaman, W. T., Ye, D., Wang, R. X., Hale, E. E., Weisse, M., and Quinli-van, E. B. (1999). Gene expression from the ORF50/K8 region of Kaposi's sarcoma-associated herpesvirus. Virology, 263, 436-449.
115. Sharp, T. V., Wang, H. W., Koumi, A. et al. (2002). K15 protein of Kaposi's sarcoma-associated herpesvirus. Virology, 263, 436-449.
116. Sinclair, A. J. (2003). bZIP proteins of human gammaherpesviruses. J. Gen. Virol., 84, 1941-1949.
117. Song, M. J., Li, X., Brown, H. J., and Sun, R. (2002). Character-ization of interactions between RTA and the promoter of polyadenylated nuclear RNA in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. J. Virol., 76, 5000-5013.
118. Spiller, O. B., Blackbourn, D. J., Mark, L., Proctor, D. G., and Blom, A. M. (2003). Functional activity of the complement regulator encoded by Kaposi's sarcoma-associated herpesvirus. J. Biol. Chem., 278, 9283-9289.
119. Staskus, K. A., Zhong, W., Gebhard, K. et al. (1997). Kaposi's sarcoma-associated herpesvirus gene expression in endothe-lial (spindle) tumor cells. J. Virol., 71, 715-719.
120. Sturzl, M., Blasig, C., Schreier, A. et al. (1997). Expression of HHV-8 latency-associated T0.7 RNA in spindle cells and endothe-lial cells of AIDS-associated, classical and African Kaposi's sar-coma. Int. J. Cancer, 72, 68-71.
121. Smuda, C., Bogner, E., and Radsak, K. (1997). The human cytomegalovirus glycoprotein B gene (ORF UL55) is expressed early in the infectious cycle. J. Gen. Virol., 78 (8), 1981-1992.
122. Sun, R., Lin, S. F., Gradoville, L., Yuan, Y., Zhu, F., and Miller, G.(1998). A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc. Natl Acad. Sci. USA, 95, 10866-10871.
123. Sun, R., Lin, S. F., Staskus, K. et al. (1999). Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression. J. Virol., 73, 2232-2242.
124. Talbot, S. J., Weiss, R. A., Kellam, P., and Boshoff, C.(1999). Transcrip-tional analysis of human herpesvirus-8 open reading frames 71, 72, 73, K14, and 74 in a primary effusion lymphoma cell line. Virology, 257, 84-94.
125. Taylor, J. L. R., Bennett, H. N., Snyder, B. A., Moore, P. S., and Chang, Y. (2005). Identification of novel transcripts in Kaposi's sarcoma-associated herpesvirus (KSHV) genome. J. Virol., 79, 15099-15106.
126. Varthakavi, V., Smith, R. M., Deng, H., Sun, R., and Spearman, P. (2002). Human immunode?ciency virus type-1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus through induction of KSHV Rta. Virology, 297, 270-280.
127. Vieira, J., Huang, M. L., Koelle, D. M., and Corey, L. (1997). Transmis-sible Kaposi's sarcoma-associated herpesvirus (human her-pesvirus 8) in saliva of men with a history of Kaposi's sarcoma. J. Virol., 71, 7083-7087.
128. Vieira, J., O'Hearn, P., Kimball, L., Chandran, B., and Corey, L. (2001). Activation of Kaposi's sarcomaassociated her-pesvirus (human herpesvirus 8) lytic replication by human cytomegalovirus. J. Virol., 75, 1378-1386.
129. Viejo-Borbolla, A., Kati, E., Shelodon, J. A. et al. (2003). A domain in the C-terminal region of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated herpesvirus affects transcrip-tional activation and binding to nuclear heterochromatin. J. Virol., 77, 7093-7100.
130. Wang, F. Z., Akula, S. M., Pramod, N. P., Zeng, L., and Chan-dran, B. (2001a). Human herpesvirus 8 envelope glycoprotein K8.1A interaction with the target cells involves heparan sulfate. J. Virol., 75, 7517-7527.
131. Wang, S. E., Wu, F. Y., Fujimuro, M., Zong, J., Hayward, S. D., and Hayward, G. S. (2003a). Role of CCAAT/enhancer-binding protein alpha (C/EBPalpha) in activation of the Kaposi's sarcoma-associated herpesvirus (KSHV) lytic-cycle replication-associated protein (RAP) promoter in cooperation with the KSHV replication and transcription activator (RTA) and RAP. J. Virol., 77, 600-623.
132. Wang, S. E., Wu, F. Y., Yu, Y., and Hayward, G. S. (2003b). CCAAT/enhancer-binding protein-alpha is induced during the early stages of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic cycle reactivationand together with the KSHV replication and transcription activator (RTA) cooperatively stimulates the viral RTA, MTA, and PAN promoters. J. Virol., 77, 9590-9612.
133. Wang, X. P., Zhang, Y. J., Deng, J. H. et al. (2001b).Characterization of the promoter region of the viral interferon regulatory factor encoded by Kaposi's sarcoma-associated herpesvirus. Onco-gene, 20, 523-530.
134. Wang, Y. Li, H., Chan, M. Y. et al. (2003c). Kaposi's sarcoma-associated herpesvirus Ori-Lyt-dependent DNA replication: Cis-acting requirements for replication and Ori-Lyt-associated RNA transcription. J. Virol., 78, 8615-8629.
135. Wirth, U. V., Gunkel, K., Engels, M., and Schwyzer, M. (1989). Spatial and temporal distribution of bovine herpesvirus1 transcripts. J. Virol., 63, 4882-4889.
136. Wong, E. L. and Damania, B. (2006). Transcriptional regulation of the Kaposi sarcoma-associated herpesvirus K15 gene J. Virol., 80, 1385-1392.
137. Wu, F. Y., Ahn, J. H., Alcendor, D. J. et al. (2001). Origin-independent assembly of Kaposi's sarcoma-associated herpesvirus DNA replication compartments in transient cotransfection assays and association with the ORF-K8 protein and cellular PML. J. Virol., 75, 1487-1506.
138. Zhong, W., Wang, H., Herndier, B., and Ganem, D. (1996). Restricted expression of Kaposi sarcomaassociated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc. Natl Acad. Sci. USA, 93, 6641-6646.
139. Zhu, F. X., Cusano, T., and Yuan, Y. (1999). Identification of the immediate-early transcripts of Kaposi's sarcoma-associated herpesvirus. J. Virol., 73, 5556-5567.
140. Ziegler, J. L. (1993). Endemic Kaposi's sarcoma in Africa and local volcanic soils. Lancet, 342, 1348-1351.
141. Zoeteweij, J. P., Moses, A. V., and Rinderknecht, A. S. (2001). Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus. Blood, 97, 2374-2380.