Synthesis, molecular modeling and biological evaluation of β-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 15, 2011, Pages 4513-4519

  Zhang, Hong Jia ^a   Zhu, Di Di ^a   Li, Zi Lin ^a   Sun, Juan ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Antibacterial activity; Cinnamic acid; FabH inhibitors; Secnidazole

Indexed keywords

1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (2 BROMOPHENYL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (2 CHLOROPHENYL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (2 FLUOROPHENYL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (2 METHOXYPHENYL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (2,4 DICHLOROPHENYL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (3 BROMOPHENYL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (3 FLUOROPHENYL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (3 METHOXYPHENYL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (4 BROMOPHENYL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (4 CHLOROPHENYL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (4 FLUOROPHENYL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (4 METHOXYPHENYL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (BIPHENYL 4 YL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (NAPHTHALEN 1 YL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (NAPHTHALEN 2 YL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 (THIOPHEN 2 YL)ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 4 TOLYLACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 [4 (BENZYLOXY)PHENYL]ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL 3 [4 (DIMETHYLAMINO)PHENYL]ACRYLATE; 1 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)PROPAN 2 YL CINNAMATE; ANTIINFECTIVE AGENT; BETA KETOACYL ACYL CARRIER PROTEIN SYNTHASE III; CARRIER PROTEIN; CINNAMIC ACID SECNIDAZOLE ESTER DERIVATIVE; KANAMYCIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; CINNAMATES; HUMANS; INHIBITORY CONCENTRATION 50; METRONIDAZOLE; MICROBIAL SENSITIVITY TESTS; MOLECULAR DYNAMICS SIMULATION;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 79960555870     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.021     Document Type: Article

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