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Volumn 312, Issue , 2012, Pages 53-60

A sensitive LC-MS/MS method for the determination of free maytansinoid DM4 concentrations - Method development, validation, and application to the nonclinical studies of antitumor agent DM4 conjugated hu-anti-Cripto MAb B3F6 (B3F6-DM4) in rats and monkeys

Author keywords

Conjugate; Cripto; DM4; LC MS MS; Maytansinoid

Indexed keywords


EID: 84863174963     PISSN: 13873806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijms.2011.05.010     Document Type: Article
Times cited : (14)

References (19)
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    • Cripto monoclonal antibodies
    • DOI 10.1358/dnp.2005.18.5.917325
    • X.F. Hu, and P.X. Xing Cripto monoclonal antibodies Drug News Perspect. 18 June (5) 2005 293 303 (Pubitemid 41491468)
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    • Hu, X.F.1    Xing, P.X.2
  • 10
    • 24344507278 scopus 로고    scopus 로고
    • Drug-conjugated monoclonal antibodies for the treatment of cancer
    • J.M. Lambert Drug-conjugated monoclonal antibodies for the treatment of cancer Curr. Opin. Pharmacol. 5 2005 543
    • (2005) Curr. Opin. Pharmacol. , vol.5 , pp. 543
    • Lambert, J.M.1
  • 11
    • 33645500289 scopus 로고    scopus 로고
    • Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing
    • H.K. Erickson, P.U. Park, W.C. Widdison, Y.V. Kovtun, L.M. Garrett, K. Hoffman, R.J. Lutz, V.S. Goldmacher, and W.A. Blattler Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing Cancer Res. 66 April (8) 2006 4427 4433
    • (2006) Cancer Res. , vol.66 , Issue.APRIL 8 , pp. 4427-4433
    • Erickson, H.K.1    Park, P.U.2    Widdison, W.C.3    Kovtun, Y.V.4    Garrett, L.M.5    Hoffman, K.6    Lutz, R.J.7    Goldmacher, V.S.8    Blattler, W.A.9
  • 12
    • 45449086322 scopus 로고    scopus 로고
    • Antibody drug conjugates: A marriage of biologics and small molecules
    • P. Arnum Antibody drug conjugates: a marriage of biologics and small molecules Pharm. Technol. 32 6 2008 54
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    • Arnum, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.