An API LC/MS/MS quantitation method for ansamitocin P-3 (AP3) and its preclinical pharmacokinetics

Journal of Pharmaceutical and Biomedical Analysis

Volumn 36, Issue 4, 2004, Pages 815-821

  Liu, Zhongfa ^a   Floss, Heinz G ^b   Cassady, John M ^a   Xiao, Jim ^a   Chan, Kenneth K ^a,c  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Ansamitocin P 3; Anticancer agents; Liquid chromatography tandem mass spectrometry; Maytansinoids; Metabolism; Pharmacokinetics

Indexed keywords

ACETIC ACID ETHYL ESTER; ACETONITRILE; ANSAMITOCIN P 3; DEPSIPEPTIDE; FORMIC ACID; FR 901228; MACROGOL 300; MACROGOL DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG ISOLATION; DRUG METABOLISM; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG EVALUATION, PRECLINICAL; MALE; MASS SPECTROMETRY; MAYTANSINE; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 7944236234     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2004.07.045     Document Type: Article

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