Areca nut extracts suppress the differentiation and functionality of human monocyte-derived dendritic cells

Journal of Periodontal Research

Volumn 47, Issue 2, 2012, Pages 198-203

  Wang, C C ^a   Chen, T Y ^b   Wu, H Y ^b   Liu, T Y ^c   Jan, T R ^b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Areca nut; Dendritic cell; Differentiation; Interleukin 12; Maturation

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CD86 PROTEIN, HUMAN; COLORING AGENT; DIAGNOSTIC AGENT; GLYCOPROTEIN P 15095; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; INTERLEUKIN 12; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; PLANT EXTRACT; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

ARECA; ARTICLE; CELL DIFFERENTIATION; CULTURE TECHNIQUE; DENDRITIC CELL; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; IMMUNOLOGY; MONOCYTE; NUT; PHENOTYPE;

ANTIGENS, CD11C; ANTIGENS, CD40; ANTIGENS, CD80; ANTIGENS, CD86; ARECA; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; COLORING AGENTS; DENDRITIC CELLS; FLOW CYTOMETRY; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HLA-DR ANTIGENS; HUMANS; INTERLEUKIN-12; INTERLEUKIN-4; LIPOPOLYSACCHARIDES; MONOCYTES; NUTS; PHENOTYPE; PLANT EXTRACTS; TETRAZOLIUM SALTS; THIAZOLES;

EID: 84863166524     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2011.01421.x     Document Type: Article

References (36)

1. Gupta PC, Warnakulasuriya S. Global epidemiology of areca nut usage. Addict Biol 2002;7:77-83.
2. IARC. Betel-quid and areca-nut chewing and some areca-nut derived nitrosamines. IARC Monogr Eval Carcinog Risks Hum 2004;85:1-334.
3. Nair U, Bartsch H, Nair J. Alert for an epidemic of oral cancer due to use of the betel quid substitutes gutkha and pan masala: a review of agents and causative mechanisms. Mutagenesis 2004;19:251-262.
4. Ling LJ, Hung SL, Tseng SC et al. Association between betel quid chewing, periodontal status and periodontal pathogens. Oral Microbiol Immunol 2001;16:364-369.
5. Bagchi M, Balmoori J, Bagchi D, Stohs SJ, Chakrabarti J, Das DK. Role of reactive oxygen species in the development of cytotoxicity with various forms of chewing tobacco and pan masala. Toxicology 2002;179:247-255.
6. Chang MC, Ho YS, Lee PH et al. Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential. Carcinogenesis 2001;22:1527-1535.
7. Chen CL, Chi CW, Liu TY. Hydroxyl radical formation and oxidative DNA damage induced by areca quid in vivo. J Toxicol Environ Health A 2002;65:327-336.
8. Jeng JH, Wang YJ, Chiang BL et al. Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline. Carcinogenesis 2003;24:1301-1315.
9. Chang MC, Chiang CP, Lin CL, Lee JJ, Hahn LJ, Jeng JH. Cell-mediated immunity and head and neck cancer: with special emphasis on betel quid chewing habit. Oral Oncol 2005;41:757-775.
10. Chiang CP, Wu HY, Liu BY, Wang JT, Kuo MY. Quantitative analysis of immunocompetent cells in oral submucous fibrosis in Taiwan. Oral Oncol 2002;38:56-63.
11. Haque MF, Harris M, Meghji S, Speight PM. An immunohistochemical study of oral submucous fibrosis. J Oral Pathol Med 1997;26:75-82.
12. Kurihara K, Hashimoto N. The pathological significance of Langerhans cells in oral cancer. J Oral Pathol 1985;14:289-298.
13. Laad A, Kode J, Chavan S, Rao R, Fakih AR, Chiplunkar S. Limiting dilution analysis of proliferating and cytotoxic lymphocytes in the peripheral blood and tumours of oral cancer patients. Eur J Cancer B Oral Oncol 1996;32B:337-342.
14. Heimdal JH, Aarstad HJ, Klementsen B, Olofsson J. Disease stage related in vitro responsiveness of peripheral blood T-lymphocytes in patients with head and neck carcinoma. Acta Otolaryngol 1998;118:887-891.
15. Haque MF, Meghji S, Khitab U, Harris M. Oral submucous fibrosis patients have altered levels of cytokine production. J Oral Pathol Med 2000;29:123-128.
16. Azuma M. Fundamental mechanisms of host immune responses to infection. J Periodontal Res 2006;41:361-373.
17. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-252.
18. Pierre P, Turley SJ, Gatti E et al. Developmental regulation of MHC class II transport in mouse dendritic cells. Nature 1997;388:787-792.
19. Banchereau J, Briere F, Caux C et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000;18:767-811.
20. Osada T, Clay TM, Woo CY, Morse MA, Lyerly HK. Dendritic cell-based immunotherapy. Int Rev Immunol 2006;25:377-413.
21. O'Neill DW, Adams S, Bhardwaj N. Manipulating dendritic cell biology for the active immunotherapy of cancer. Blood 2004;104:2235-2246.
22. Ebner S, Ratzinger G, Krosbacher B et al. Production of IL-12 by human monocyte-derived dendritic cells is optimal when the stimulus is given at the onset of maturation, and is further enhanced by IL-4. J Immunol 2001;166:633-641.
23. Hung SL, Chen YL, Wan HC, Liu TY, Chen YT, Ling LJ. Effects of areca nut extracts on the functions of human neutrophils in vitro. J Periodontal Res 2000;35:186-193.
24. Hung SL, Cheng YY, Peng JL, Chang LY, Liu TY, Chen YT. Inhibitory effects of areca nut extracts on phagocytosis of Actinobacillus actinomycetemcomitans ATCC 33384 by neutrophils. J Periodontol 2005;76:373-379.
25. Wang CC, Liu TY, Wey SP, Wang FI, Jan TR. Areca nut extract suppresses T-cell activation and interferon-gamma production via the induction of oxidative stress. Food Chem Toxicol 2007;45:1410-1418.
26. Wang CC, Lin HL, Wey SP, Jan TR. Areca-nut extract modulates antigen-specific immunity and augments inflammation in ovalbumin-sensitized mice. Immunopharmacol Immunotoxicol 2010;33:315-322.
27. Liu TY, Chen CL, Chi CW. Oxidative damage to DNA induced by areca nut extract. Mutat Res 1996;367:25-31.
28. Romani N, Gruner S, Brang D et al. Proliferating dendritic cell progenitors in human blood. J Exp Med 1994;180:83-93.
29. Snijders A, Hilkens CM, van derPouwKraan TC, Engel M, Aarden LA, Kapsenberg ML. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J Immunol 1996;156:1207-1212.
30. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
31. Kumpawat K, Deb S, Ray S, Chatterjee A. Genotoxic effect of raw betel-nut extract in relation to endogenous glutathione levels and its mechanism of action in mammalian cells. Mutat Res 2003;538:1-12.
32. Chicha L, Jarrossay D, Manz MG. Clonal type I interferon-producing and dendritic cell precursors are contained in both human lymphoid and myeloid progenitor populations. J Exp Med 2004;200:1519-1524.
33. Cutler CW, Jotwani R. Antigen presentation and the role of dendritic cells in periodontitis. Periodontology 2000 2004;35:135-157.
34. Muller HK, Dandie GW, Ragg SJ, Woods GM. Langerhans cell alterations in cutaneous carcinogenesis. In vivo (Athens, Greece) 1993;7:293.
35. Das SN, Khanna NN, Khanna S. In vivo and in vitro observation of cellular immune parameters in squamous cell carcinoma of the oral cavity and its correlation with tumor load and prognosis. Cancer Invest 1986;4:207-216.
36. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003;3:133-146.