WIN-34B may have analgesic and anti-inflammatory effects by reducing the production of pro-inflammatory mediators in cells via inhibition of IκB signaling pathways

Biomolecules and Therapeutics

Volumn 20, Issue 1, 2012, Pages 50-56

  Kim, Kyoung Soo ^a   Choi, Hyun Mi ^a   Yang, Hyung In ^b   Yoo, Myung Chul ^a  

^a Kyung Hee University Hospital   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

Analgesic effect; Anemarrhena asphodeloides BUNGE; Anti inflammatory effect; Lonicera japonica thunb; WIN 34B

Indexed keywords

ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CELECOXIB; COLLAGENASE 3; I KAPPA B; I KAPPA B ALPHA; INDOMETACIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WIN 34B;

ANALGESIC ACTIVITY; ANEMARRHENA ASPHODELOIDES; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; LONICERA JAPONICA; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN DEGRADATION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE;

EID: 84863157946     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2012.20.1.050     Document Type: Article

References (27)

1. Ameye, L. G. and Chee, W. S. (2006) Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis. Res. Ther. 8, R127.
2. Bhatia, H. S., Candelario-Jalil, E., de Oliveira, A. C., Olajide, O. A., Martínez-Sánchez, G. and Fiebich, B. L. (2008) Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells. Arch. Biochem. Biophys. 477, 253-258.
3. Choi, H. M., Lee, Y. A., Lee, S. H., Hong, S. J., Hahm, D. H., Choi, S. Y., Yang, H. I., Yoo, M. C. and Kim, K. S. (2009) Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators. Arthritis. Res. Ther. 11, R161.
4. Choi, H. M., Oh da, H., Bang, J. S., Yang, H. I., Yoo, M. C. and Kim, K. S. (2010) Differential effect of IL-1β and TNFα on the production of IL-6, IL-8 and PGE2 in fibroblast-like synoviocytes and THP-1 macrophages. Rheumatol. Int. 30, 1025-1033.
5. Dat, N. T., Jin, X., Hong, Y. S. and Lee, J. J. (2010) An isoaurone and other constituents from Trichosanthes kirilowii seeds inhibit hypoxia-inducible factor-1 and nuclear factor-kappaB. J. Nat. Prod. 73, 1167-1169.
6. dos Santos, M. D., Almeida, M. C., Lopes, N.P., de Souza, G. E. (2006) valuation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol. Pharm. Bull. 29, 2236-2240.
7. Gottlieb, S. (2001) COX 2 inhibitors may increase risk of heart attack. BMJ. 323, 471.
8. Hartog, A., Hougee, S., Faber, J., Sanders, A., Zuurman, C., Smit, H. F., van der Kraan, P. M., Hoijer, M. A. and Garssen, J. (2008) The multicomponent phytopharmaceutical SKI306X inhibits in vitro cartilage degradation and the production of inflammatory mediators. Phytomedicine. 15, 313-320.
9. Hippisley-Cox, J. and Coupland, C. (2005) Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis. BMJ. 330, 1366.
10. Huang, N., Hauck, C., Yum, M. Y., Rizshsky, L., Widrlechner, M.P, McCoy, J. A., Murphy, P. A., Dixon, P. M., Nikolau, B. J. and Birt, D. F. (2009) Rosmarinic acid in Prunella vulgaris ethanol extract inhibits lipopolysaccharide-induced prostaglandin E2 and nitric oxide in RAW 264.7 mouse macrophages. J. Agric. Food Chem. 57, 10579-10589.
11. Jung, K., Lee, B., Han, S. J., Ryu, J. H. and Kim, D. H. (2009) Mangiferin ameliorates scopolamine-induced learning deficits in mice. Biol. Pharm. Bull. 32, 242-246.
12. Kang, M., Jung, I., Hur, J., Kim, S. H., Lee, J. H., Kang, J. Y., Jung, K. C., Kim, K. S., Yoo, M. C., Park, D. S., Lee, J. D. and Cho, Y. B. (2010) The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo. J. Ethnopharmacol. 131, 485-496.
13. Kidd, B. L. (2006) Osteoarthritis and joint pain. Pain. 123, 6-9.
14. Kim, J. Y., Shin, J. S., Ryu, J. H., Kim, S. Y., Cho, Y. W., Choi, J. H. and Lee, K. T. (2009) Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPSinduced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways. Food Chem. Toxicol. 47, 1610-1617.
15. Kim, K. S., Park, E. K., Ju, S. M., Jung, H. S., Bang, J. S., Kim, C., Lee, Y. A., Hong, S. J., Lee, S. H., Yang, H. I. and Yoo, M. C. (2007) Taurine chloramine differentially inhibits matrix metalloproteinase 1 and 13 synthesis in interleukin-1beta stimulated fibroblast-like synoviocytes. Arthritis. Res. Ther. 9, R80.
16. Kwak, W. J., Han, C. K., Chang, H. W., Kim, H. P., Kang, S. S. and Son, K. H. (2003) Loniceroside C, an antiinflammatory saponin from Lonicera japonica. Chem. Pharm. Bull (Tokyo). 51, 333-335.
17. Lark, M. W., Bayne, E. K., Flanagan, J., Harper, C. F., Hoerrner, L. A., Hutchinson, N. I., Singer, I. I., Donatelli, S. A., Weidner, J. R., Williams, H. R., Mumford, R. A. and Lohmander, L. S. (1997) Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. J. Clin. Invest. 100, 93-106.
18. Lee, J. H., Park, J. H., Kim, Y. S. and Han, Y. (2008) Chlorogenic acid, a polyphenolic compound, treats mice with septic arthritis caused by Candida albicans. Int. Immunopharmacol. 8, 1681-1685.
19. Lenzer, J. (2005) FDA advisers warn: COX 2 inhibitors increase risk of heart attack and stroke. BMJ. 330, 440.
20. Park, E. K., Ryu, M. H., Kim, Y. H., Lee, Y. A., Lee, S. H., Woo, D. H., Hong, S. J., Han, J. S., Yoo, M. C., Yang, H. I. and Kim, K. S. (2006) Anti-inflammatory effects of an ethanolic extract from Clematis mandshurica Rupr. J. Ethnopharmacol. 108, 142-147.
21. Qian, Z. M., Wen, X. D., Li, H. J., Liu, Y., Qin, S. J. and Li, P. (2008) Analysis of interaction property of bioactive components in Flos Lonicerae Japonicae with protein by microdialysis coupled with HPLC-DAD-MS. Biol. Pharm. Bull. 31, 126-130.
22. Reddivari, L., Vanamala, J., Chintharlapalli, S., Safe, S. H. and Miller, J. C. Jr. (2007) Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspasedependent and caspase-independent pathways. Carcinogenesis. 28, 2227-2235.
23. Schiavoni, G., Mauri, C., Carlei, D., Belardelli, F., Pastoris, M. C. and Proietti, E. (2004) Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gammaindependent pathway. J. Immunol. 173, 1266-1275.
24. Shan, J., Fu, J., Zhao, Z., Kong, X., Huang, H., Luo, L. and Yin, Z. (2009) Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-kappaB and JNK/AP-1 activation. Int. Immunopharmacol. 9, 1042-1048.
25. Shi, S., Jiang, D., Dong, C. and Tu, P. (2006) Triterpene saponins from clematis mandshurica. J. Nat. Prod. 69, 1591-1595.
26. Soliman, K. F. and Mazzio, E. A. (1998) In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds. Proc. Soc. Exp. Biol. Med. 218, 390-397.
27. Wolfe, F. and Cathey, M. A. (1991) The assessment and prediction of functional disability in rheumatoid arthritis. J. Rheumatol. 18, 1298-1306.