The multicomponent phytopharmaceutical SKI306X inhibits in vitro cartilage degradation and the production of inflammatory mediators

Phytomedicine

Volumn 15, Issue 5, 2008, Pages 313-320

  Hartog, A ^a,c   Hougee, S ^a   Faber, J ^a   Sanders, A ^a   Zuurman, C ^d   Smit, H F ^a   van der Kraan, P M ^b   Hoijer, M A ^a   Garssen, J ^a,c  

^a NUMICO RESEARCH   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d NONE

Author keywords

Arthritis; Cartilage; Clematis mandshurica; Inflammation; Prunella vulgaris; SKI306X; Trichosanthes kirilowii

Indexed keywords

ANTIINFLAMMATORY AGENT; CARARTHRON; CLEMATIS MANDSHURICA EXTRACT; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; PROTEOGLYCAN; PRUNELLA VULGARIS EXTRACT; SKI 306X; TRICHOSANTHES KIRILOWII EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTILAGE; CARTILAGE DEGENERATION; CARTILAGE PROTECTION; CELL STIMULATION; CLEMATIS MANDSHURICA; CONCENTRATION RESPONSE; CONTROLLED STUDY; COW; HUMAN; HUMAN CELL; IN VITRO STUDY; MEDICINAL PLANT; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROPHYLAXIS; PROSTAGLANDIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; PRUNELLA VULGARIS; TRICHOSANTHES KIRILOWII;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARTILAGE; CATTLE; CLEMATIS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; GLYCOSAMINOGLYCANS; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; NITRIC OXIDE; PRUNELLA; TRICHOSANTHES; TUMOR NECROSIS FACTOR-ALPHA;

BOVINAE; CLEMATIS; PRUNELLA VULGARIS; TRICHOSANTHES KIRILOWII;

EID: 41949124085     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2007.09.005     Document Type: Article

References (27)

1. Andrews H.J., Edwards T.A., Cawston T.E., and Hazleman B.L. Transforming growth factor-beta causes partial inhibition of interleukin 1-stimulated cartilage degradation in vitro. Biochem. Biophys. Res. Commun. 162 (1989) 144-150
2. Attur M.G., Patel I.R., Patel R.N., Abramson S.B., and Amin A.R. Autocrine production of IL-1 beta by human osteoarthritis-affected cartilage and differential regulation of endogenous nitric oxide, IL-6, prostaglandin E2, and IL-8. Proc. Assoc. Am. Physicians 110 (1998) 65-72
3. Caron J.P., Fernandes J.C., Martel-Pelletier J., Tardif G., Mineau F., Geng C., and Pelletier J.P. Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression. Arthritis Rheum. 39 9 (1996) 1535-1544
4. Chandrasekhar S., and Harvey A.K. Transforming growth factor-beta is a potent inhibitor of IL-1 induced protease activity and cartilage proteoglycan degradation. Biochem. Biophys. Res. Commun. 157 (1988) 1352-1359
5. Choi J.H., Kim D.Y., Yoon J.H., Youn H.Y., Yi J.B., Rhee H.I., Ryu K.H., Jung K., Han C.K., Kwak W.J., and Cho Y.B. Effects of SKI 306X, a new herbal agent, on proteoglycan degradation in cartilage explant culture and collagenase-induced rabbit osteoarthritis model. Osteoarthritis Cartilage 10 (2002) 471-478
6. Curtis C.L., Rees S.G., Little C.B., Flannery C.R., Hughes C.E., Wilson C., Dent C.M., Otterness I.G., Harwood J.L., and Caterson B. Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids. Arthritis Rheum. 46 (2002) 1544-1553
7. Dionne R.A., Khan A.A., and Gordon S.M. Analgesia and COX-2 inhibition. Clin. Exp. Rheumatol. 19 (2001) S63-S70
8. Farndale R.W., Sayers C.A., and Barrett A.J. A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Connect. Tissue Res. 9 (1982) 247-248
9. Fernandes J.C., Martel-Pelletier J., and Pelletier J.P. The role of cytokines in osteoarthritis pathophysiology. Biorheology 39 (2002) 237-246
10. Goldring M.B., Suen L.F., Yamin R., and Lai W.F. Regulation of collagen gene expression by prostaglandins and interleukin-1beta in cultured chondrocytes and fibroblasts. Am. J. Ther. 3 (1996) 9-16
11. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., and Tannenbaum S.R. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem. 126 (1982) 131-138
12. Hardy M.M., Seibert K., Manning P.T., Currie M.G., Woerner B.M., Edwards D., Koki A., and Tripp C.S. Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants. Arthritis Rheum. 46 (2002) 1789-1803
13. Henrotin Y.E., Bruckner P., and Pujol J.P. The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthritis Cartilage 11 (2003) 747-755
14. Jung Y.B., Roh K.J., Jung J.A., Jung K., Yoo H., Cho Y.B., Kwak W.J., Kim D.K., Kim K.H., and Han C.K. Effect of SKI 306X, a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study. Am. J. Chin. Med. 29 (2001) 485-491
15. Jung Y.B., Seong S.C., Lee M.C., Shin Y.U., Kim D.H., Kim J.M., Jung Y.K., Ahn J.H., Seo J.G., Park Y.S., Lee C.S., Roh K.J., Han C.K., Cho Y.B., Chang D.Y., Kwak W.J., Jung K.O., and Park B.J. A four-week, randomized, double-blind trial of the efficacy and safety of SKI306X: a herbal anti-arthritic agent versus diclofenac in osteoarthritis of the knee. Am. J. Chin. Med. 32 (2004) 291-301
16. Larrick J.W., and Kunkel S.L. The role of tumor necrosis factor and interleukin 1 in the immunoinflammatory response. Pharm. Res. 5 (1988) 129-139
17. Lee S.W., Chung W.T., Choi S.M., Kim K.T., Yoo K.S., and Yoo Y.H. Clematis mandshurica protected to apoptosis of rat chondrocytes. J. Ethnopharmacol. 101 (2005) 294-298
18. Miwa M., Saura R., Hirata S., Hayashi Y., Mizuno K., and Itoh H. Induction of apoptosis in bovine articular chondrocyte by prostaglandin E(2) through cAMP-dependent pathway. Osteoarthritis Cartilage 8 (2000) 17-24
19. Pelletier J.P., DiBattista J.A., Roughley P., McCollum R., and Martel-Pelletier J. Cytokines and inflammation in cartilage degradation. Rheum. Dis. Clin. North Am. 19 (1993) 545-568
20. Pelletier J.P., Jovanovic D.V., Lascau-Coman V., Fernandes J.C., Manning P.T., Connor J.R., Currie M.G., and Martel-Pelletier J. Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level. Arthritis Rheum. 43 (2000) 1290-1299
21. Probert L., Plows D., Kontogeorgos G., and Kollias G. The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice. Eur. J. Immunol. 25 (1995) 1794-1797
22. Revell P.A., Mayston V., Lalor P., and Mapp P. The synovial membrane in osteoarthritis: a histological study including the characterisation of the cellular infiltrate present in inflammatory osteoarthritis using monoclonal antibodies. Ann. Rheum. Dis. 47 (1988) 300-307
23. Trebino C.E., Stock J.L., Gibbons C.P., Naiman B.M., Wachtmann T.S., Umland J.P., Pandher K., Lapointe J.M., Saha S., Roach M.L., Carter D., Thomas N.A., Durtschi B.A., McNeish J.D., Hambor J.E., Jakobsson P.J., Carty T.J., Perez J.R., and Audoly L.P. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc. Natl. Acad. Sci. USA 100 (2003) 9044-9049
24. van Beuningen H.M., van der Kraan P.M., Arntz O.J., and van den Berg W.B. Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: studies in anatomically intact cartilage in vitro and in vivo. Ann. Rheum. Dis. 52 (1993) 185-191
25. van de Loo F.A., Arntz O.J., van Enckevort F.H., van Lent P.L., and van den Berg W.B. Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in NOS2-deficient mice and in anti-interleukin-1-treated wild-type mice with unabated joint inflammation. Arthritis Rheum. 41 (1998) 634-646
26. van de Loo F.A., Joosten L.A., van Lent P.L., Arntz O.J., and van den Berg W.B. Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis. Arthritis Rheum. 38 (1995) 164-172
27. van der Kraan P.M., and van den Berg W.B. Anabolic and destructive mediators in osteoarthritis. Curr. Opin. Clin. Nutr. Metab. Care 3 (2000) 205-211