Increased apoptosis and decreased proliferation of colonic epithelium in dextran sulfate sodium-induced colitis in mice

Oncology Reports

Volumn 24, Issue 4, 2010, Pages 869-874

  Araki, Yoshio ^a   Mukaisyo, Ken Ichi ^a   Sugihara, Hiroyuki ^a   Fujiyama, Yoshihide ^a   Hattori, Takanori ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Apoptosis; Cell cycle; Dextran sulfate sodium induced colitis; G0 arrest; Proliferation

Indexed keywords

DEXTRAN SULFATE; KI 67 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER SUSCEPTIBILITY; CELL PROLIFERATION; COLITIS; COLON MUCOSA; CONTROLLED STUDY; DIET; DRUG INDUCED DISEASE; EPITHELIUM CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MICROSCOPY; MITOSIS; MORPHOLOGICAL TRAIT; MOUSE; NICK END LABELING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; COLITIS, ULCERATIVE; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFLAMMATION; INTESTINAL MUCOSA; KI-67 ANTIGEN; MALE; MICE; MICE, INBRED BALB C;

EID: 77957326596     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000932     Document Type: Article

References (35)

1. Papadakis KA and Targan SR: Current theories on the causes of inflammatory bowel disease. Gastroenterol Clin North Am 28: 283-296, 1999.
2. Lewis JD, Deren JJ and Lichtensten GR: Cancer risk in patient with inflammatory bowel diseases. Gastroenterol Clin North Am 28: 459-477, 1999.
3. Pohl C, Hombach A and Kruis W: Chronic inflammatory bowel disease and cancer. Hepatogastroenterology 47: 57-70, 2000.
4. Mayer L: The development of animal models of inflammatory bowel disease. Int Rev Immunol 19: 77-90, 2000.
5. Blumberg RS, Saubermann LJ and Strober W: Animal models of mucosal inflammation and their relation to human inflammatory bowel disease. Curr Opin Immunol 11: 648-656, 1999.
6. Elson CO, Sartor RB, Tennyson GS and Riddell RH: Experimental models of inflammatory bowel disease. Gastroenterology 109: 1344-1367, 1995.
7. Ricketts CR: Dextran sulphate-α synthetic analogue of heparin. Biochem J 51: 129-133, 1952.
8. Araki Y, Andoh A and Fujiyama Y: The free radical scavenger edaravone suppresses experimental dextran sulfate sodium-induced colitis in rats. Int J Mol Med 12: 125-129, 2003.
9. Araki Y, Sugihara H and Hattori T: The free radical scavengers edaravone and tempol suppress experimental dextran sulfate sodium-induced colitis in mice. Int J Mol Med 17: 331-334, 2006.
10. Araki Y, Andoh A, Takizawa J, Takizawa W and Fujiyama Y: Clostridium butyricum, a probiotic derivative, suppresses dextran sulfate sodium-induced experimental colitis in rats. Int J Mol Med 13: 577-580, 2004.
11. Araki Y, Sugihara H and Hattori T: In vitro effects of dextran sulfate sodium on a Caco-2 cell line and plausible mechanisms for dextran sulfate sodium-induced colitis. Oncol Rep 16: 1357-1362, 2006.
12. Araki Y, Andoh A, Koyama S, Fujiyama Y, Kanauchi O and Bamba T: Effects of germinated barley foodstuff on microflora and short chain fatty acid production in dextran sulfate sodium-induced colitis in rats. Biosci Biotechnol Biochem 64: 1794-1800, 2000.
13. Araki Y, Fujiyama Y, Andoh A, Koyama S, Kanauchi O and Bamba T: The dietary combination of germinated barley foodstuff plus Clostridium butyricum suppresses the dextran sulfate sodium-induced experimental colitis in rats. Scand J Gastroenterol. 35: 1060-1067, 2000.
14. Araki Y, Andoh A, Fujiyama Y, Kanauchi O, Takenaka K, Higuchi A and Bamba T: Germinated barley foodstuff exhibits different adsorption properties for hydrophilic versus hydrophobic bile acids. Digestion 64: 248-254, 2001.
15. Kanauchi O, Mitsuyama K, Homma T, Takahama K, Fujiyama Y, Andoh A, Araki Y, Suga T, Hibi T, Naganuma M, Asakura H, Nakano H, Shimoyama T, Hida N, Haruma K, Koga H, Sata M, Tomiyasu N, Toyonaga A, Fukuda M, Kojima A and Bamba T: Treatment of ulcerative colitis patients by long-term administration of germinated barley foodstuff: multi-center open trial. Int J Mol Med 12: 701-704, 2003.
16. Foligne B, Dessein R, Marceau M, Poiret S, Chamaillard M, Pot B, Simonet M and Daniel C: Prevention and treatment of colitis with Lactococcus lactis secreting the immunomodulatory Yersinia LcrV protein. Gastroenterology 133: 862-874, 2007.
17. Jones BA and Gores GJ: Physiology and pathophysiology of apoptosis in epithelial cells of the liver, pancreas, and intestine. Am J Physiol 273: G1174-G1188, 1997.
18. Watson AJ and Pritchard DM: Lesson from genetically engineered animal model. VII. Apopthosis of intestinal epithelium: Lesson from transgenic and knockout mice. Am J Physiol Gastrointest Liver Physiol 278: 1-5, 2000.
19. Iwamoto M, Koji T, Makiyama K, Kobayashi N and Nakane PK: Apoptosis of crypt epithelial cells in ulcerative colitis. J Pathol 180: 152-159, 1996.
20. Strater J, Wellisch I, Riedl S, Walczak H, Koretz K, Tandara A, Krammer PH and Moller P: CD95 (APO-1/fas) mediated apoptosis in colon epithelial cells a possible role in ulcerative colitis. Gastroenterology 113: 160-167, 1997.
21. Iimura M, Nakamura T, Shinozaki S, Iizuka B, Inove Y, Suzuki S and Hayashi N: Bax is downregulated in inflamed colonic mucosa of ulcerative colitis. Gut 47: 228-235, 2000.
22. Serafini EP, Kirk AP and Chambers TJ: Rate and pattern of epithelial cell proliferation in ulcerative colitis. Gut 22: 648-652, 1981.
23. Andersen SN, Rognum TO, Bakka A and Clausen OP: Ki-67: A useful marker for the evaluation of dysplasia in ulcerative colitis. Mol Pathol 51: 327-332, 1998.
24. Arai N, Mitomi H, Ohtani Y, Igarashi M, Kakita A and Okayasu I: Exhanced epithelial cell turnover associated with p53 accumulation and high p21WAF1/CIP1 expression in ulcerative colitis. Mod Pathol 12: 604-611, 1999.
25. Tardieu D, Jaeg JP, Deloly A, Corpet DE, Cadet J and Petit CR: The COX-2 inhibitor nimesulide suppresses superoxide and 8-hydroxy-deoxyguanosine formation, and stimulates apoptosis in mucosa during early colonic inflammation in rats. Carcinogenesis 25: 973-976, 2000.
26. Tessner TG, Cohn SM, Schloemann S and Stenson WF: Prostaglandins prevent decreased epithelial cell proliferation associated with dextran sodium sulfate injury in mice. Gastroenterology 115: 874-882, 1998.
27. Vetuschi A, Latella G, Sferra R, Caprilli R and Gaudio E: Increased proliferation and apoptosis of colonic epithelial cells in dextran sulfate sodium-induced colitis in rats. Dig Dis Sci 47: 1447-1457, 2002.
28. Inoue T, Murano M, Kuramoto T, Ishida K, Kawakami K, Abe Y, Morita E, Murano N, Toshina K, Nishikawa T, Maemura K, Shimamoto C, Hirata I, Katsu K and Higuchi K: Increased proliferation of middle to distal colonic cells during colorectal carcinogenesis in experimental murine ulcerative colitis. Oncol Rep 18: 1457-1462, 2007.
29. Oda T: Role of mast cells in dextran sulfate sodium-induced experimental colitis in rats. J Kyoto Pref Univ Med 104: 1069-1082, 1995.
30. Cooper HS, Murthy S, Kido K, Yoshitake H and Flanigan A: Dysplasia and cancer in dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: A study of histopathology, β catenin and p53 expression and the role of inflammation. Carcinogenesis 21: 757-768, 2000.
31. Chiba T: Cell kinetiks of carcinoma originating from rat colitis induced by dextran sulphate sodium. Nippon Shokakibyo Gakkai Zasshi (In Japanese) 90: 774-781, 1993.
32. Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y and Nakaya R: A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98: 694-702, 1990.
33. Lipkin M: Biomarkers of increased susceptibility to gastrointestinal cancer: New application to studies of cancer prevention on human subjects. Cancer Res 48: 235-245, 1988.
34. Hans W, Scholmerich J, Gross V and Falk W: The role of the resident intestinal flora in acute and chronic dextran sulfate sodium induced colitis in mice. Eur J Gastroenterol Hepatol 12: 267-273, 2000. (Pubitemid 30168579)
35. Kitajima S, Takuma S and Morimoto M: Changes in colonic mucosal permeability in mouse colitis induced with dextran sulfate sodium. Exp Anim 48: 137-143, 1999.