Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes

Journal of Biological Chemistry

Volumn 287, Issue 7, 2012, Pages 4894-4903

  Zhi, Xiaoyong ^a   Zhou, X Edward ^a   Melcher, Karsten ^a   Motola, Daniel L ^b,f   Gelmedin, Verena ^d   Hawdon, John ^d   Kliewer, Steven A ^b,c   Mangelsdorf, David J ^b,c   Xu, H Eric ^a,e  

^a VAN ANDEL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

^d GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^e SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CAENORHABDITIS ELEGANS; COMPLEX STRUCTURE; FARNESOID X RECEPTORS; LARVAL STAGE; LIGAND BINDING; LIGAND BINDING DOMAIN; MOLECULAR MECHANISM; NUCLEAR RECEPTORS; PARASITE-; SIGNALING PATHWAYS; STRUCTURAL FRAMEWORKS; STRUCTURE ANALYSIS; THERAPEUTIC TARGETS; X RAY CRYSTAL STRUCTURES;

LIGANDS; MAMMALS; PIGMENTS; SIGNALING;

BODY FLUIDS;

BILE ACID; CELL NUCLEUS RECEPTOR; CHOLESTENOIC ACID; DAFACHRONIC ACID; FARNESOID X RECEPTOR; PROTEIN DAF 12; UNCLASSIFIED DRUG;

ANCYLOSTOMA CEYLANICUM; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; HOST PARASITE INTERACTION; LIGAND BINDING; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; STRUCTURE ANALYSIS;

ANCYLOSTOMA; ANCYLOSTOMIASIS; ANIMALS; BILE ACIDS AND SALTS; CHOLESTENES; CRYSTALLOGRAPHY, X-RAY; HELMINTH PROTEINS; MAMMALS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURAL HOMOLOGY, PROTEIN;

ANCYLOSTOMA CEYLANICUM; ANCYLOSTOMATOIDEA; CAENORHABDITIS ELEGANS; MAMMALIA; NEMATODA;

EID: 84863143896     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.315242     Document Type: Article

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