I ks Protects from ventricular arrhythmia during cardiac ischemia and reperfusion in rabbits by preserving the repolarization reserve

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Guo, Xiaogang ^a   Gao, Xiuren ^a   Wang, Yesong ^a   Peng, Longyun ^a   Zhu, Yingying ^b   Wang, Shenming ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b Central Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL KCNQ1; SLOWLY ACTIVATED DELAYED RECTIFIER POTASSIUM CHANNEL; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; ACETAMIDE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR; DELAYED RECTIFIER POTASSIUM CHANNEL; KCNQ1 PROTEIN, HUMAN; L 768673; POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY CIRCUMFLEX BRANCH; DOWN REGULATION; FEMALE; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE POTENTIAL; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART REPOLARIZATION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; MALE; NONHUMAN; PROTEIN EXPRESSION; RABBIT; ACTION POTENTIAL; ANIMAL; CHEMISTRY; GENE EXPRESSION REGULATION; HEART ARRHYTHMIA; HEART VENTRICLE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PERICARDIUM; REPERFUSION INJURY; TIME;

ORYCTOLAGUS CUNICULUS;

ACETAMIDES; ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; BENZODIAZEPINONES; DELAYED RECTIFIER POTASSIUM CHANNELS; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION; HEART VENTRICLES; KCNQ1 POTASSIUM CHANNEL; MALE; MYOCARDIAL ISCHEMIA; PERICARDIUM; POTASSIUM CHANNELS; RABBITS; RECEPTORS, ADRENERGIC, BETA; REPERFUSION INJURY; TIME FACTORS;

EID: 84863125632     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031545     Document Type: Article

References (41)

1. Roden DM, Yang T, (2005) Protecting the heart against arrhythmias: potassium current physiology and repolarization reserve. Circulation 112: 1376-1378.
2. Lengyel C, Iost N, Virag L, Varro A, Lathrop DA, et al. (2001) Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QT(c) and action potential duration. Br J Pharmacol 132: 101-110.
3. Volders PG, Stengl M, van Opstal JM, Gerlach U, Spatjens RL, et al. (2003) Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation. Circulation 107: 2753-2760.
4. Jost N, Virag L, Bitay M, Takacs J, Lengyel C, et al. (2005) Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle. Circulation 112: 1392-1399.
5. Carmeliet E, (1999) Cardiac ionic currents and acute ischemia: from channels to arrhythmias. Physiol Rev 79: 917-1017.
6. Ducroq J, Rouet R, Salle L, Puddu PE, Repesse Y, et al. (2006) Class III effects of dofetilide and arrhythmias are modulated by [K+]o in an in vitro model of simulated-ischemia and reperfusion in guinea-pig ventricular myocardium. Eur J Pharmacol 532: 279-289.
7. Bes S, Vandroux D, Tissier C, Devillard L, Brochot A, et al. (2005) Direct, pleiotropic protective effect of cyclosporin A against simulated ischemia-induced injury in isolated cardiomyocytes. Eur J Pharmacol 511: 109-120.
8. Jiang M, Cabo C, Yao J, Boyden PA, Tseng G, (2000) Delayed rectifier K currents have reduced amplitudes and altered kinetics in myocytes from infarcted canine ventricle. Cardiovasc Res 48: 34-43.
9. Dun W, Boyden PA, (2005) Diverse phenotypes of outward currents in cells that have survived in the 5-day-infarcted heart. Am J Physiol Heart Circ Physiol 289: H667-673.
10. Zicha S, Moss I, Allen B, Varro A, Papp J, et al. (2003) Molecular basis of species-specific expression of repolarizing K+ currents in the heart. Am J Physiol Heart Circ Physiol 285: H1641-1649.
11. Watanabe I, Kanda A, Engle CL, Gettes LS, (1997) Comparison of the effects of regional ischemia and hyperkalemia on the membrane action potentials of the in situ pig heart. Experimental Cardiology Group, University of North Carolina at Chapel Hill. J Cardiovasc Electrophysiol 8: 1229-1236.
12. Ganitkevich V, Reil S, Schwethelm B, Schroeter T, Benndorf K, (2006) Dynamic responses of single cardiomyocytes to graded ischemia studied by oxygen clamp in on-chip picochambers. Circ Res 99: 165-171.
13. Shieh RC, John SA, Lee JK, Weiss JN, (1996) Inward rectification of the IRK1 channel expressed in Xenopus oocytes: effects of intracellular pH reveal an intrinsic gating mechanism. J Physiol 494 (Pt 2): 363-376.
14. Hondeghem LM, Carlsson L, Duker G, (2001) Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic. Circulation 103: 2004-2013.
15. Martin RL, Su Z, Limberis JT, Palmatier JD, Cowart MD, et al. (2006) In vitro preclinical cardiac assessment of tolterodine and terodiline: multiple factors predict the clinical experience. J Cardiovasc Pharmacol 48: 199-206.
16. Viitasalo M, Paavonen KJ, Swan H, Kontula K, Toivonen L, (2005) Effects of epinephrine on right ventricular monophasic action potentials in the LQT1 versus LQT2 form of long QT syndrome: preferential enhancement of "triangulation" in LQT1. Pacing Clin Electrophysiol 28: 219-227.
17. Milberg P, Eckardt L, Bruns HJ, Biertz J, Ramtin S, et al. (2002) Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes. J Pharmacol Exp Ther 303: 218-225.
18. Milberg P, Fleischer D, Stypmann J, Osada N, Monnig G, et al. (2007) Reduced repolarization reserve due to anthracycline therapy facilitates torsade de pointes induced by IKr blockers. Basic Res Cardiol 102: 42-51.
19. Lu HR, Vlaminckx E, Van Ammel K, De Clerck F, (2002) Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations. Eur J Pharmacol 452: 183-192.
20. Champeroux P, Viaud K, El Amrani AI, Fowler JS, Martel E, et al. (2005) Prediction of the risk of Torsade de Pointes using the model of isolated canine Purkinje fibres. Br J Pharmacol 144: 376-385.
21. Valverde CA, Kornyeyev D, Ferreiro M, Petrosky AD, Mattiazzi A, et al. (2010) Transient Ca2+ depletion of the sarcoplasmic reticulum at the onset of reperfusion. Cardiovasc Res 85: 671-680.
22. Liu GX, Zhou J, Koren G, (2008) Single-channel properties of I K,slow1 and I K,slow2 in mouse ventricular myocytes. Pflugers Arch 456: 541-547.
23. Chouabe C, Neyroud N, Guicheney P, Lazdunski M, Romey G, et al. (1997) Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias. Embo J 16: 5472-5479.
24. Tsuji Y, Zicha S, Qi XY, Kodama I, Nattel S, (2006) Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes. Circulation 113: 345-355.
25. Aggarwal R, Boyden PA, (1995) Diminished Ca2+ and Ba2+ currents in myocytes surviving in the epicardial border zone of the 5-day infarcted canine heart. Circ Res 77: 1180-1191.
26. Potet F, Scott JD, Mohammad-Panah R, Escande D, Baro I, (2001) AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex. Am J Physiol Heart Circ Physiol 280: H2038-2045.
27. Chen L, Kurokawa J, Kass RS, (2005) Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel. J Biol Chem 280: 31347-31352.
28. Freeman LC, Lippold JJ, Mitchell KE, (2000) Glycosylation influences gating and pH sensitivity of I(sK). J Membr Biol 177: 65-79.
29. Chang JS, Wendt T, Qu W, Kong L, Zou YS, et al. (2008) Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products. Circ Res 102: 905-913.
30. Jespersen T, Membrez M, Nicolas CS, Pitard B, Staub O, et al. (2007) The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family. Cardiovasc Res 74: 64-74.
31. Hondeghem LM, (2008) Use and abuse of QT and TRIaD in cardiac safety research: importance of study design and conduct. Eur J Pharmacol 584: 1-9.
32. Jespersen T, Grunnet M, Olesen SP, (2005) The KCNQ1 potassium channel: from gene to physiological function. Physiology (Bethesda) 20: 408-416.
33. Morales C, Gonzalez GE, Rodriguez M, Bertolasi CA, Gelpi RJ, (2002) Histopathologic time course of myocardial infarct in rabbit hearts. Cardiovasc Pathol 11: 339-345.
34. Franz MR, (1991) Method and theory of monophasic action potential recording. Prog Cardiovasc Dis 33: 347-368.
35. Walker MJA, (1988) The lambeth conventions: guidelines for the study of arrhythmias in ischaemia, infarction, and reperfusion. Cardiovasc Res pp. 447-455.
36. Guerard NC, Traebert M, Suter W, Dumotier BM, (2008) Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart. J Pharmacol Toxicol Methods 58: 32-40.
37. Lynch JJ Jr, Houle MS, Stump GL, Wallace AA, Gilberto DB, et al. (1999) Antiarrhythmic efficacy of selective blockade of the cardiac slowly activating delayed rectifier current, I(Ks), in canine models of malignant ischemic ventricular arrhythmia. Circulation 100: 1917-1922.
38. Salataa JJ, Selnickb HG, Lynch JJ Jr, (2004) Pharmacological modulation of I(Ks): potential for antiarrhythmic therapy. Curr Med Chem 11: 29-44.
39. Rose J, Armoundas AA, Tian Y, DiSilvestre D, Burysek M, et al. (2005) Molecular correlates of altered expression of potassium currents in failing rabbit myocardium. Am J Physiol Heart Circ Physiol 288: H2077-2087.
40. Ramakers C, Vos MA, Doevendans PA, Schoenmakers M, Wu YS, et al. (2003) Coordinated down-regulation of KCNQ1 and KCNE1 expression contributes to reduction of I(Ks) in canine hypertrophied hearts. Cardiovasc Res 57: 486-496.
41. Liu XS, Jiang M, Zhang M, Tang D, Clemo HF, et al. (2007) Electrical remodeling in a canine model of ischemic cardiomyopathy. Am J Physiol Heart Circ Physiol 292: H560-571.