The CD49d +/high subpopulation from isolated human breast sarcoma spheres possesses tumor-initiating ability

International Journal of Oncology

Volumn 40, Issue 3, 2012, Pages 665-672

  Lee, Kyung Min ^a   Han, Wonshik ^a   Kim, Jong Bin ^a   Shin, Incheol ^b   Ko, Eunyoung ^a   Park, In Ae ^a   Lee, Dong Sup ^a   Oh, Kuenhee ^a   Noh, Dong Young ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Breast sarcoma; CD49d; Tumor initiating cells

Indexed keywords

ALPHA4 INTEGRIN; CD133 ANTIGEN; CD24 ANTIGEN; CELL MARKER; DOXORUBICIN; EPITHELIAL CELL ADHESION MOLECULE; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; UVOMORULIN; VIMENTIN;

ADHERENT CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST SARCOMA; CANCER CELL CULTURE; CARCINOGENESIS; CELL PROLIFERATION; CELL RENEWAL; CELL SUBPOPULATION; CELL VIABILITY; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; GENE SEQUENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MESENCHYME CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMA CELL; SARCOSPHERE; TUMOR INITIATING CELL;

ANIMALS; BREAST NEOPLASMS; CARCINOGENS; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; INTEGRIN ALPHA4; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASTIC STEM CELLS; SARCOMA; TUMOR CELLS, CULTURED;

EID: 84863116872     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1289     Document Type: Article

References (33)

1. Lobo NA, Shimono Y, Qian D and Clarke MF: The biology of cancer stem cells. Annu Rev Cell Dev Biol 23: 675-699, 2007.
2. Reya T, Morrison SJ, Clarke MF and Weissman IL: Stem cells, cancer, and cancer stem cells. Nature 414: 105-111, 2001. (Pubitemid 33041634)
3. Kakarala M and Wicha MS: Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J Clin Oncol 26: 2813-2820, 2008.
4. Dean M, Fojo T and Bates S: Tumour stem cells and drug resistance. Nat Rev Cancer 5: 275-284, 2005. (Pubitemid 40488633)
5. Bonnet D and Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3: 730-737, 1997. (Pubitemid 27298715)
6. + cell population is enriched in tumor-initiating cells. Cancer Res 67: 6796-6805, 2007.
7. Zhang S, Balch C, Chan MW, et al: Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res 68: 4311-4320, 2008.
8. Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al: Identification and expansion of human colon-cancer-initiating cells. Nature 445: 111-115, 2007. (Pubitemid 46067311)
9. Schatton T, Murphy GF, Frank NY, et al: Identification of cells initiating human melanomas. Nature 451: 345-349, 2008.
10. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ and Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100: 3983-3988, 2003. (Pubitemid 36418143)
11. Gibbs CP, Kukekov VG, Reith JD, et al: Stem-like cells in bone sarcomas: implications for tumorigenesis. Neoplasia 7: 967-976, 2005.
12. Meltzer PS: Is Ewing's sarcoma a stem cell tumor? Cell Stem Cell 1: 13-15, 2007.
13. Suva ML, Riggi N, Stehle JC, et al: Identification of cancer stem cells in Ewing's sarcoma. Cancer Res 69: 1776-1781, 2009.
14. Trent IJ 2nd, Benjamin RS and Valero V: Primary soft tissue sarcoma of the breast. Curr Treat Options Oncol 2: 169-176, 2001.
15. Confavreux C, Lurkin A, Mitton N, et al: Sarcomas and malignant phyllodes tumours of the breast - a retrospective study. Eur J Cancer 42: 2715-2721, 2006. (Pubitemid 44739987)
16. Dalen T, Coebergh JW, Casparie MK, et al: Soft tissue sarcoma: the predominant primary malignancy in the retroperitoneum. Sarcoma 5: 5-8, 2001. (Pubitemid 32319863)
17. Lien HC, Hsiao YH, Lin YS, et al: Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition. Oncogene 26: 7859-7871, 2007. (Pubitemid 350261788)
18. Giancotti FG and Tarone G: Positional control of cell fate through joint integrin/receptor protein kinase signaling. Annu Rev Cell Dev Biol 19: 173-206, 2003. (Pubitemid 37487347)
19. Watt FM: Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J 21: 3919-3926, 2002.
20. Guo W and Giancotti FG: Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 5: 816-826, 2004. (Pubitemid 39336275)
21. Stingl J, Eirew P, Ricketson I, et al: Purification and unique properties of mammary epithelial stem cells. Nature 439: 993-997, 2006. (Pubitemid 43292419)
22. Pontier SM and Muller WJ: Integrins in mammary-stem-cell biology and breast-cancer progression - a role in cancer stem cells? J Cell Sci 122: 207-214, 2009.
23. Vaillant F, Asselin-Labat ML, Shackleton M, Forrest NC, Lindeman GJ and Visvader JE: The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res 68: 7711-7717, 2008.
24. Kouros-Mehr H, Bechis SK, Slorach EM, et al: GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell 13: 141-152, 2008. (Pubitemid 351163164)
25. Dontu G, Abdallah WM, Foley JM, et al: In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 17: 1253-1270, 2003. (Pubitemid 36583168)
26. Dontu G and Wicha MS: Survival of mammary stem cells in suspension culture: implications for stem cell biology and neoplasia. J Mammary Gland Biol Neoplasia 10: 75-86, 2005. (Pubitemid 40724024)
27. Shackleton M, Vaillant F, Simpson KJ, et al: Generation of a functional mammary gland from a single stem cell. Nature 439: 84-88, 2006. (Pubitemid 43053633)
28. Christensen L, Nielsen M, Holund B and Clemmensen I: Differentiation between metaplastic carcinomas and sarcomas of the human female breast by fibronectin. Virchows Arch A Pathol Anat Histopathol 407: 465-476, 1985. (Pubitemid 15248303)
29. Rose DM, Han J and Ginsberg MH: Alpha4 integrins and the immune response. Immunol Rev 186: 118-124, 2002.
30. Pontier SM and Muller WJ: Integrins in breast cancer dormancy. APMIS 116: 677-684, 2008.
31. Damiano JS, Cress AE, Hazlehurst LA, Shtil AA and Dalton WS: Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood 93: 1658-1667, 1999. (Pubitemid 29102494)
32. Marco RA, Diaz-Montero CM, Wygant JN, Kleinerman ES and McIntyre BW: Alpha 4 integrin increases anoikis of human osteosarcoma cells. J Cell Biochem 88: 1038-1047, 2003. (Pubitemid 36337045)
33. Casey RC, Burleson KM, Skubitz KM, et al: Beta1-integrin regulate the formation and adhesion of ovarian carcinoma multicellular spheroids. Am J Pathol 159: 2071-2080, 2001. (Pubitemid 33104261)