Receptor tyrosine kinase Ephb6 regulates vascular smooth muscle contractility and modulates blood pressure in concert with sex hormones

Journal of Biological Chemistry

Volumn 287, Issue 9, 2012, Pages 6819-6829

  Luo, Hongyu ^a   Wu, Zenghui ^a   Tremblay, Johanne ^a   Thorin, Eric ^b   Peng, Junzheng ^a   Lavoie, Julie L ^a   Hu, Bing ^d   Stoyanova, Ekatherina ^a   Cloutier, Guy ^a   Qi, Shijie ^a   Wu, Tao ^c   Cameron, Mark ^e   Wu, Jiangping ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MONTREAL HEART INSTITUTE   (Canada)

^c ZHEJIANG UNIVERSITY   (China)

^d AmeriPath   (United States)

^e UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEINS; CELL SURFACE MOLECULES; EPHRINS; EX-VIVO; FEEDBACK MECHANISMS; IN-VITRO; MYOSIN LIGHT CHAINS; RECEPTOR TYROSINE KINASE; REVERSE SIGNALING; SEX HORMONES; VASCULAR SMOOTH MUSCLE CELLS; VASCULAR SMOOTH MUSCLES;

AMINO ACIDS; BLOOD PRESSURE; CELL MEMBRANES; ENZYMES; EXPERIMENTS; GENES; HORMONES; MAMMALS; PHOSPHORYLATION;

LIGANDS;

ADAPTOR PROTEIN; CATECHOLAMINE; EPHRIN; EPHRIN RECEPTOR B6; LIGAND; MYOSIN LIGHT CHAIN KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SEX HORMONE; TESTOSTERONE; TYROSINE KINASE RECEPTOR;

ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; CROSS LINKING; EX VIVO STUDY; FEMALE; MALE; MOUSE; MUSCLE CONTRACTILITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; VASCULAR SMOOTH MUSCLE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOOD PRESSURE; FEMALE; HUMANS; HYPERTENSION; MALE; MESENTERIC ARTERIES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; NERVE TISSUE PROTEINS; ORCHIECTOMY; RECEPTOR, EPHB6; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TESTOSTERONE; VASOCONSTRICTION;

ANIMALIA; MUS;

EID: 84863115944     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.293365     Document Type: Article

References (40)

1. Weir, M. R., and Bakris, G. L. (2008) Combination therapy with reninangiotensin-aldosterone receptor blockers for hypertension.Howfar have we come? J. Clin. Hypertens. 10, 146-152
2. Victor, R. G., and Shafiq, M. M. (2008) Sympathetic neural mechanisms in human hypertension. Curr. Hypertens. Rep. 10, 241-247
3. Versari, D., Daghini, E., Virdis, A., Ghiadoni, L., and Taddei, S. (2009) Endothelium-dependent contractions and endothelial dysfunction in human hypertension. Br. J. Pharmacol. 157, 527-536
4. Iglarz, M., and Schiffrin, E. L. (2003) Role of endothelin-1 in hypertension. Curr. Hypertens. Rep. 5, 144-148 (Pubitemid 38898944)
5. Qiao, X., McConnell, K. R., and Khalil, R. A. (2008) Sex steroids and vascular responses in hypertension and aging. Gend. Med. 5, S46-S64 (Pubitemid 351455231)
6. Kienitz, T., and Quinkler, M. (2008) Testosterone and blood pressure regulation. Kidney Blood Press Res. 31, 71-79 (Pubitemid 351630063)
7. Ashraf, M. S., and Vongpatanasin, W. (2006) Estrogen and hypertension. Curr. Hypertens. Rep. 8, 368-376 (Pubitemid 44463720)
8. Eph Nomenclature Committee (1997) Unified nomenclature for Eph family receptors and their ligands, the ephrins. Cell 90, 403-404
9. Pasquale, E. B. (2008) Eph-ephrin bidirectional signalling in physiology and disease. Cell 133, 38-52
10. Wilkinson, D. G. (2000) Eph receptors and ephrins. Regulators of guidance and assembly. Int. Rev. Cytol. 196, 177-244
11. Flanagan, J. G., and Vanderhaeghen, P. (1998) The ephrins and Eph receptors in neural development. Annu. Rev. Neurosci. 21, 309-345 (Pubitemid 28150666)
12. Wang, H. U., Chen, Z. F., and Anderson, D. J. (1998) Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 93, 741-753 (Pubitemid 28257581)
13. Noren, N. K., and Pasquale, E. B. (2007) Paradoxes of the EphB4 receptor in cancer. Cancer Res. 67, 3994-3997 (Pubitemid 46815041)
14. Wu, J., and Luo, H. (2005) Recent advances on T-cell regulation by receptor tyrosine kinases. Curr. Opin. Hematol. 12, 292-297 (Pubitemid 41058393)
15. Batlle, E., Henderson, J. T., Beghtel, H., van den Born, M. M., Sancho, E., Huls, G., Meeldijk, J., Robertson, J., van de Wetering, M., Pawson, T., and Clevers H. (2002) β-Catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 111, 251-263 (Pubitemid 35292445)
16. Dravis, C., Yokoyama, N., Chumley, M. J., Cowan, C. A., Silvany, R. E., Shay, J., Baker, L. A., and Henkemeyer, M. (2004) Bidirectional signalling mediated by ephrin-B2 and EphB2 controls urorectal development. Dev. Biol. 271, 272-290 (Pubitemid 38833661)
17. Konstantinova, I., Nikolova, G., Ohara-Imaizumi, M., Meda, P., Kucera, T., Zarbalis, K., Wurst, W., Nagamatsu, S., and Lammert, E. (2007) EphA-Ephrin-A-mediated β cell communication regulates insulin secretion from pancreatic islets. Cell 129, 359-370 (Pubitemid 46574973)
18. Davy, A., Bush, J. O., and Soriano, P. (2006) Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol. 4, e315
19. Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T., and Matsuo, K. (2006) Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab. 4, 111-121 (Pubitemid 44138718)
20. Pasquale, E. B. (2005) Eph receptor signalling casts a wide net on cell behaviour. Nat. Rev. Mol. Cell Biol. 6, 462-475
21. Arvanitis, D., and Davy, A. (2008) Eph/ephrin signaling. Networks. Genes Dev. 22, 416-429
22. Hashimoto, T., Karasawa, T., Saito, A., Miyauchi, N., Han, G. D., Hayasaka, K., Shimizu, F., and Kawachi, H. (2007) Ephrin-B1 localizes at the slit diaphragm of the glomerular podocyte. Kidney Int. 72, 954-964 (Pubitemid 47530571)
23. Dravis, C., Wu, T., Chumley, M. J., Yokoyama, N., Wei, S., Wu, D. K., Marcus, D. C., and Henkemeyer, M. (2007) EphB2 and ephrin-B2 regulate the ionic homeostasis of vestibular endolymph. Hear. Res. 223, 93-104 (Pubitemid 44959578)
24. Foo, S. S., Turner, C. J., Adams, S., Compagni, A., Aubyn, D., Kogata, N., Lindblom, P., Shani, M., Zicha, D., and Adams, R. H. (2006) Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell 124, 161-173 (Pubitemid 43069317)
25. Shin, D., Garcia-Cardena, G., Hayashi, S., Gerety, S., Asahara, T., Stavrakis, G., Isner, J., Folkman, J., Gimbrone, M. A., Jr., and Anderson, D. J. (2001) Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev. Biol. 230, 139-150 (Pubitemid 32171413)
26. Gale, N. W., Baluk, P., Pan, L., Kwan, M., Holash, J., DeChiara, T. M., McDonald, D. M., and Yancopoulos, G. D. (2001) Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev. Biol. 230, 151-160 (Pubitemid 32171414)
27. Deroanne, C., Vouret-Craviari, V., Wang, B., and Pouysségur, J. (2003) EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. J. Cell Sci. 116, 1367-1376 (Pubitemid 36410674)
28. Ogita, H., Kunimoto, S., and Kamioka, Y. (2003) EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. Circ. Res. 93, 23-31 (Pubitemid 36859037)
29. Luo, H., Yu, G., Tremblay, J., and Wu, J. (2004) EphB6-null mutation results in compromised T cell function. J. Clin. Invest. 114, 1762-1773 (Pubitemid 40385532)
30. Golovina, V. A., and Blaustein, M. P. (2006) Preparation of primary cultured mesenteric artery smooth muscle cells for fluorescent imaging and physiological studies. Nat. Protoc. 1, 2681-2687
31. Thorin, E., Huang, P. L., Fishman, M. C., and Bevan, J. A. (1998) Nitric oxide inhibits α2-adrenoceptor-mediated endothelium-dependent vasodilation. Circ. Res. 82, 1323-1329 (Pubitemid 28294752)
32. Lavoie, J. L., Lake-Bruse, K. D., and Sigmund, C. D. (2004) Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule. Am. J. Physiol. Renal Physiol 286, F965-F971 (Pubitemid 38508997)
33. Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A., and Kaibuchi, K. (1996) Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science 273, 245-248 (Pubitemid 26285892)
34. Tanaka, M., Kamo, T., Ota, S., and Sugimura, H. (2003) Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion. EMBO J. 22, 847-858 (Pubitemid 36227787)
35. Brückner, K., Pablo Labrador, J., Scheiffele, P., Herb, A., Seeburg, P. H., and Klein, R. (1999) EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron 22, 511-524 (Pubitemid 29159850)
36. Lu, Q., Sun, E. E., Klein, R. S., and Flanagan, J. G. (2001) Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction. Cell 105, 69-79 (Pubitemid 32323917)
37. Gkretsi, V., Apte, U., Mars, W. M., Bowen, W. C., Luo, J. H., Yang, Y., Yu, Y. P., Orr, A., St-Arnaud, R., Dedhar, S., Kaestner, K. H., Wu, C., and Michalopoulos, G. K. (2008) Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology 48, 1932-1941
38. Dong, H., O'Brien, R. J., Fung, E. T., Lanahan, A. A., Worley, P. F., and Huganir, R. L. (1997) GRIP. A synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature 386, 279-284 (Pubitemid 27142513)
39. Su, L. F., Wang, Z., and Garabedian, M. J. (2002) Regulation of GRIP1 and CBP Coactivator activity by Rho GDI modulates estrogen receptor transcriptional enhancement. J. Biol. Chem. 277, 37037-37044
40. Ye, B., Liao, D., Zhang, X., Zhang, P., Dong, H., and Huganir, R. L. (2000) GRASP-1. A neuronal RasGEF associated with the AMPA receptor/GRIP complex. Neuron 26, 603-617