Synthesis, optimization, and characterization of camptothecin-loaded acetalated dextran porous microparticles for pulmonary delivery

Molecular Pharmaceutics

Volumn 9, Issue 2, 2012, Pages 290-298

  Meenach, Samantha A ^a   Kim, Yu Jeong ^a   Kauffman, Kevin J ^b   Kanthamneni, Naveen ^a   Bachelder, Eric M ^a   Ainslie, Kristy M ^a,b  

^a Department of Medicine   (United States)

^b Ohio State University   (United States)

Author keywords

camptothecin; inhalable dry particles; local drug delivery; optimization of emulsion chemistry; pulmonary microparticles

Indexed keywords

ACETALATED DEXTRAN; CAMPTOTHECIN; DEXTRAN; POLYESTER; POLYGLACTIN; UNCLASSIFIED DRUG;

ARTICLE; CROSSFLOW FILTRATION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SYNTHESIS; ELECTRIC RESISTANCE; EMULSION; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG CAVITY; MACROPHAGE; MOLECULAR WEIGHT; PH; PRIORITY JOURNAL;

ACETALS; ADMINISTRATION, INHALATION; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CELL LINE, TUMOR; DELAYED-ACTION PREPARATIONS; DEXTRANS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN-ION CONCENTRATION; LACTIC ACID; LUNG; MACROPHAGES, ALVEOLAR; MICROSPHERES; MOLECULAR WEIGHT; PARTICLE SIZE; POLYGLYCOLIC ACID; POROSITY;

EID: 84863115470     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2003785     Document Type: Article

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