Capsaicin-induced apoptosis of FaDu human pharyngeal squamous carcinoma cells

Yonsei Medical Journal

Volumn 53, Issue 4, 2012, Pages 834-841

  Le, Thanh Do ^a   Jin, Dong Chun ^a   Rho, Se Ra ^a   Kim, Myung Su ^a   Yu, Rina ^b   Yoo, Hoon ^a  

^a Chosun University   (South Korea)

^b University of Ulsan   (South Korea)

Author keywords

Apoptosis; Capsaicin; Cell cycle arrest; Human pharyngeal squamous carcinoma cells

Indexed keywords

CAPSAICIN; CASPASE 3; CELL NUCLEUS DNA; CYCLIN B1; CYCLIN D1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P85;

AGAR GEL ELECTROPHORESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL POPULATION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CHROMATIN CONDENSATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSOL; DNA FRAGMENTATION; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRION; PHARYNGEAL SQUAMOUS CARCINOMA CELL; PHARYNX CARCINOMA; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; BLOTTING, WESTERN; CAPSAICIN; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; MICROSCOPY, FLUORESCENCE; PHARYNGEAL NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84863105106     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2012.53.4.834     Document Type: Article

References (25)

1. Chen AY, Myers JN. Cancer of the oral cavity. Curr Probl Surg 2000;37:633-731.
2. Figuero Ruiz E, Carretero Peláez MA, Cerero Lapiedra R, Esparza Gómez G, Moreno López LA. Effects of the consumption of alcohol in the oral cavity: relationship with oral cancer. Med Oral 2004;9:14-23.
3. Pintos J, Black MJ, Sadeghi N, Ghadirian P, Zeitouni AG, Viscidi RP, et al. Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada. Oral Oncol 2008;44:242-50.
4. Day TA, Davis BK, Gillespie MB, Joe JK, Kibbey M, Martin-Harris B, et al. Oral cancer treatment. Curr Treat Options Oncol 2003;4:27-41.
5. Yang KM, Pyo JO, Kim GY, Yu R, Han IS, Ju SA, et al. Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines. Cell Mol Biol Lett 2009;14:497-510.
6. Oyagbemi AA, Saba AB, Azeez OI. Capsaicin: a novel chemopreventive molecule and its underlying molecular mechanisms of action. Indian J Cancer 2010;47:53-8.
7. Huang SP, Chen JC, Wu CC, Chen CT, Tang NY, Ho YT, et al. Capsaicin-induced apoptosis in human hepatoma HepG2 cells. Anticancer Res 2009;29:165-74.
8. Kim JD, Kim JM, Pyo JO, Kim SY, Kim BS, Yu R, et al. Capsaicin can alter the expression of tumor forming-related genes which might be followed by induction of apoptosis of a Korean stomach cancer cell line, SNU-1. Cancer Lett 1997;120:235-41.
9. Yoshitani SI, Tanaka T, Kohno H, Takashima S. Chemoprevention of azoxymethane-induced rat colon carcinogenesis by dietary capsaicin and rotenone. Int J Oncol 2001;19:929-39.
10. Morré DJ, Chueh PJ, Morré DM. Capsaicin inhibits preferentially the NADH oxidase and growth of transformed cells in culture. Proc Natl Acad Sci U S A 1995;92:1831-5.
11. Jung MY, Kang HJ, Moon A. Capsaicin-induced apoptosis in SK-Hep-1 hepatocarcinoma cells involves Bcl-2 downregulation and caspase-3 activation. Cancer Lett 2001;165:139-45.
12. Lee YS, Nam DH, Kim JA. Induction of apoptosis by capsaicin in A172 human glioblastoma cells. Cancer Lett 2000;161:121-30.
13. Lee JM, Moehlenkamp JD, Hanson JM, Johnson JA. Nrf2-dependent activation of the antioxidant responsive element by tert-butylhydroquinone is independent of oxidative stress in IMR-32 human neuroblastoma cells. Biochem Biophys Res Commun 2001;280: 286-92.
14. Szallasi A, Blumberg PM. Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev 1999;51:159-212.
15. Cho YS, Park SY, Lee CK, Lee EY, Shin JH, Yoo B, et al. Enhanced cough response to hyperpnea with cold air challenge in chronic cough patients showing increased cough sensitivity to inhaled capsaicin. Allergy 2003;58:486-91.
16. Amantini C, Mosca M, Nabissi M, Lucciarini R, Caprodossi S, Arcella A, et al. Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation. J Neurochem 2007;102:977-90.
17. Kim MY, Trudel LJ, Wogan GN. Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation. Anticancer Res 2009;29:3733-40.
18. Kim CS, Park WH, Park JY, Kang JH, Kim MO, Kawada T, et al. Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-activated receptor gamma in HT-29 human colon cancer cells. J Med Food 2004;7:267-73.
19. Ip SW, Lan SH, Huang AC, Yang JS, Chen YY, Huang HY, et al. Capsaicin induces apoptosis in SCC-4 human tongue cancer cells through mitochondria-dependent and-independent pathways. Environ Toxicol 2010. [Epub ahead of print]
20. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281:1309-12.
21. Desagher S, Martinou JC. Mitochondria as the central control point of apoptosis. Trends Cell Biol 2000;10:369-77.
22. Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 1996;86:147-57.
23. Borner C. The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol Immunol 2003;39:615-47.
24. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999;397:441-6.
25. Gil YG, Kang MK. Capsaicin induces apoptosis and terminal differentiation in human glioma A172 cells. Life Sci 2008;82:997-1003.