Effects of the consumption of alcohol in the oral cavity: Relationship with oral cancer;Efectos del consumo de alcohol etílico en la cavidad oral: Relación con el cáncer oral

Medicina Oral

Volumn 9, Issue 1, 2004, Pages 14-23

  Figuero Ruiz, Elena ^a,b   Carretero Peláez, Ma Ángeles ^a   Cerero Lapiedra, Rocío ^a   Esparza Gómez, Germán ^a   Moreno López, Luis Alberto ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b Facultad de Odontologia de la UCM ^*  (Spain)

Author keywords

Acetaldehyde; Alcohol dehydrogenase (ADH); Aldehyde dehydrogenase (ALDH); Cytochrome P4502E1; Ethanol; Ethyl alcohol; Polymorphisms; Retinoids

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALCOHOL DEHYDROGENASE; CYTOCHROME P450 2E1; RETINOID;

ALCOHOL CONSUMPTION; CARCINOGENESIS; GENETIC POLYMORPHISM; HUMAN; MEMBRANE PERMEABILITY; MOUTH CANCER; MOUTH CAVITY; MOUTH MUCOSA; PATHOGENESIS; REVIEW; RISK FACTOR; TOBACCO;

ALCOHOL DRINKING; ETHANOL; HUMANS; MOUTH; MOUTH NEOPLASMS; SMOKING;

EID: 0942265260     PISSN: 11372834     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (79)

1. Caries J, eds. La química del vino. Barcelona: Oikos-Tau Editores; 1972. p. 32-9.
2. Mencías Rodríguez E, Mayero Franco LM, eds. Manual de toxicología básica. Madrid:Diaz Santos Editores; 2000. p. 335-51.
3. Secades Villa R, eds. Alcoholismo juvenil: prevención y tratamiento. Madrid: Pirámide Editores SA; 1996. p. 17-56.
4. Il Congreso Internacional de alcohólicos rehabilitados. Cero grados, 2001; 7.
5. Schüller, A, eds. Alcohol y enfermedad. Madrid: Eudema Editores SA: 1991. p. 17-33 y p. 336-7.
6. López Jiménez J, Giménez Prats MJ, Boj Quesada JR., Caballero Herrera R. Alcoholismo: consideraciones estomatológicas. Archivos de Odontoestomatología. 1999;15:391-7.
7. Shukla S, Sun G, Gibson W, Savolainen MJ, Alling C and Hoek JB. Ethanol and lipid metabolic signalling. Alcoholism: Clinical and Experimental Research May Supplement 2001;25:33-9.
8. Rayo Llerena I, Marín Huerta E. Vino y corazón. Revista española de cardiología 1998;51:435-49.
9. Teixedor R., Guardia J, eds. Medicina Interna. Tomo I. Barcelona: Masson Editores; 1998. p. 1556-9.
10. Abelson D, Mandel I, Karmiol M. Salivary studies in alcoholics cirrhosis. Oral Surg Oral Med Oral Pathol 1971;41:188-92.
11. Mandel L. Salivary glands-Alcoholic sialoadenosis. Oral and Maxillofacial Surgery, Columbia University, School of Dental & Oral Surgery, Disponible en http://cpmcnet.columbia.edu./dept/dental/OMS/OMS_salivary010.html.
12. Mandel L, Baurmash H. Parotid enlargement due to alcoholism. JADA 1971;82:369-73.
13. Giovannini U. Sialoadenosi. Plastic Surgery Institute of the University of Milan, disponible en http://users.unimi.it/chpalst/ups/_10t09e.html.
14. Maier H, Mayer B, Adler D, Mall G, Born IA. Lipomatous atrophy of the parotid gland in chronic alcohol consumption. Laryngorhinootologie 1990; 69:600-4.
15. Scott J, Burns J, Flowr EA. Histological analysys of parotid and submandibular glands in chronic alcohol abuser: a necropsy study. J Clinic Pathol 1988;41:837-40.
16. García-Pola Vallejo M°L López Arranz JS. Criterios clínicos para calcular el riesgo de malignización de la lesión leucoplásica. Avances en Odontoestomatología 1991;7:89-102.
17. Gupta, P. Epidemiologic study of the association between alcohol habits and oral leukoplakia. Community Dental Oral Epidemiol 1984;12:47-50.
18. Evstifeeva TV, Zaride, DG. Nass use, cigarette smoking, alcohol consumption and risk of oral and oesophageal precancer. Eur J Cancer B Oral Oncology 1991;28B:29-35.
19. Shiu MN, Chen THH, Chang SH, Hahn LJ. Risk factors for leukoplakia and malignant transformation to oral carcinoma: a leukoplakia cohort in Taiwan. British Journal of Cancer 2000;82:1871-4.
20. Macigo, FG, and Guthua, SW. Influence of dose cessation of kiraiku, cigarettes and alcohol use on the risk of developing oral leukoplakia. European J of Oral Science 1996;104:498-502.
21. Macigo FG, Mwaniki DL, Guthua SW. The association between oral leukoplakia and use of tobacco, alcohol and khat based on relative risks assessment in Kenya. Europ J Oral Science 1995;103:268-73.
22. Hashibe M, Sankaranarayanan R, Thomas G, Kuruvilla B, Mathew B, Somanathan T, et al. Alcohol drinking, body mass index and the risk of oral leukoplakia in an Indian population. Int J Cancer 2000;88:129-34.
23. Dean Ferrer A, Alanillos FJ, Sánchez J, Peñalba M, Dean Ferrer R, Salvatierra J. Eritroplasia de la cavidad oral. Una lesión precancerosa agresiva: presentación de seis casos clínicos. Medicina Oral 2000;5:324-30.
24. Gándara JM, García A, Gándara P, Blanco A, Somoza JM, y Gallas M. Lesiones precancerosas de la cavidad oral. Medicina Oral 1999;4:588-606.
25. Hashibe M, Kuruvilla B, Thomas G, Sankaranarayanan R, Maxwell D, Zhang Z. Chewing tobacco, alcohol and the risk of erythroplakia. Cancer Epidemiology Biomarkers & Prevention 2000;9:639-45.
26. Eisenberg E, Krutchoff DJ. Lichenoid lesions of oral mucosa. Oral Surg Oral Med Oral Pathol 1992;73:699-704.
27. Krutchoff D, Cuttler L, Laskowski S. Oral lichen planus: the evidence regarding potential malignant transformation. J Oral Pathol Med 1978;7:1-7.
28. Camps M, Bagán JV. Ramón C, Gavaldá C. Asociación entre liquen plano oral y carcinoma de células escamosas. Presentación de seis casos. Revista Europea de Odontoestomatología 1999;XI:217-26.
29. Velasco Ortega E, Martínez Sahuquillo A, Vigo M, Valencia S, Bullón P. La valoración del liquen plano como proceso cancerizable. A propósito de un caso. Archivos de Odontoestomatología 1996;12:3-12.
30. Homann N, Jousimies H, Jokelainen K, Heine R, Salaspuro M. High acetaldehyde levels in saliva after ethanol consumption; methodological aspects and pathogenic implications. Carcinogenesis 1997;18:1739-43.
31. Homann N, Kärkkäinen P, Koivisto T, Jokelainen K, Salaspuro M. Effects of acetaldehyde on cell regeneration and differentiation of the upper gastrointestinal tract mucosa. J Natl. Cancer Instit 1997;89:1692-7.
32. Homann N, Tillonen J, Meurman J, Rintamáki H, Lindqvist C, Rautio M, et al. Increased salivary acetaldehyde levels in heavy drinkers and smokers: a microbiological approach to oral cavity cancer. Carcinogenesis 2000;21:663-8.
33. Homann N, Tillonen J, Rintamäki H, Salaspuro M, Lindqvist C, Meurman JH. Poor dental status increases acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkers. Oral Oncology 2001;37:153-8.
34. Seitz H, Matsuzaki S, Yokohama A, Homann N, Väkeväiene S, Dong X. Alcohol and cancer. Alcoholism: Clinical and Experimental Research 2001; 25:137-143.
35. Franceschi S, Bidoli E, Herrero R, Muñoz N. Comparison of cancers of the oral cavity and pharynx worldwide: etiological clues. Oral Oncology 2001; 36:106-15.
36. La Vecchia C, Tavani A, Franceschi S, Levi F, Corrao G, Negri E. Epidemiology and prevention of oral cancer. Oral Oncology 1997;33:302-12.
37. Ogden GR, Wight AJ. Aetiology of oral cancer: alcohol. British Journal of Oral & Maxillofacial Surgery 1998;36:247-51.
38. Wight AJ, Ogden GR. Possible mechanism by which alcohol may influence the development of oral cancer-a review. Oral Oncology 1998;34:441-7.
39. Marshall J, Graham S, Haughey B, Shedd D, O'Shea R, Brasure J, et al. Smoking, alcohol dentition and diet in the epidemiology of oral cancer. Oral Oncology Eur J Cancer 1995;28:9-15.
40. Serra M, La Vecchia C, Luchini F, Ramón JM, Franceschi S, Ribas L, et al. Tendencia de la mortalidad por cáncer orofaríngeo en España. 1955-1989. Archivos de Eighteenth-Estomatología 1993;9:169-73.
41. Macfarlane GJ, Zheng T, Marshal JR, Boffetta P, Niu S, Brasure J, et al. Alcohol, tobacco, diet and the risk of oral cancer: a pooled analysis of three case-control studies. Oral Oncology Eur J Cancer 1995;31:181-7.
42. Zheng T, Holford T, Chen Y, Jiang P, Zhang B, Boyle P. Risk of tongue cancer associate with tobacco smoking and alcohol consumption: a case-control study. Oral Oncology 1997;33:82-5.
43. Mackenzie J, Ah-See K, Thakker N, Sloan P, Maran A, Birch et al. Increasing incidence of oral cancer among young persons: what is the aetiology? Oral oncology 2000;36:387-9.
44. IARC Monographs. The evaluation of the carcinogenic risk of chemicals to humans: alcohol and alcoholic beverages. Volume 44. Lyon: International Agency for research on cancer; 1988. Disponible en http://193.51.164.11/htdocs/monographs/Vol44/44.htm.
45. Valentine JA, Scott J, West C, Hill A. A histological analysys of the early effects of alcohol and tobacco usage on human lingual epithelium. J Oral Pathol 1985;14:654-65.
46. Franceschi S, Talamini S, Barra S, Barón A, Negri E, Bidoli E, et al. Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx and esophagus in northern Italy. Cancer research 1995;50:6502-7.
47. Howie NM, Williams DM. The effect of ethanol on the permeability of oral mucosa to albumin and sucrose. J Dental Research 1995;74:889.
48. Uematsu F, Kikuchi H, Sagami I, Kanamaru R, Abe T, Satoh K, et al. Association between restriction fragment length polymorphism of the human cytochrome P-450IIE1 gene and susceptibility to lung cancer. Jpn J Cancer Res 1991;82:254-6
49. Trigkas TK., Cruchley AT., Williams DM, Wertz P, Squier. Human oral mucosal permeability is increased by short term exposure to ethanol. J Dental Research 1993;72:694.
50. Peter CJ. The role of acetaldehyde in the actions of alcohol (Update 2000) Alcoholism: Clinical and Experimental Research 2001;25:15-32.
51. IARC Monographs. The evaluation of the carcinogenic risk of chemicals to humans: allyl components, aldehydes, epoxides and peroxides, Vol. 71. Lyon: International Agency for research on cancer; 1985. Disponible en http://193.164.11/htdocs/Monographs/Vol71/005-acetaldehyde.html.
52. Harty L, Caporaso N, Hayers R, Winn D, Bravo-Otero E, Blot W, et al. Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers. J Nat Canc Institute 1997;89:1698-704.
53. Popp W, Wolf R, Vahrenholz C, Radtke J, Schell C, Kraus, R, et al. Sister chromatid exchange frequencies in lymphocytes of oral cancer patients seem to be influenced by drinking habits. Carcinogenesis 1994;15:1603-7.
54. Yokohama A, Muramatsu T, Ohmori T, Hayashida M, Ishii H. Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japonese males. Cancer Epidemiol Biomarkers Prev 1996;5:99-102.
55. Moreno López LA, Esparza Gómez G, González Navarro A, Cerero Lapiedra R, González Hernández MJ, Domínguez Rojas V. Risk of oral cancer associated with tobacco smoking, alcohol consumption and oral hygiene: a case-control study in Madrid, Spain. Oral Oncology 2000;36:170-4.
56. Schwartz S, Doody D, Dawn E, Ricks S, Porter P, Chen C. Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypes. Cancer Epidemiol, Biomark & Prevent 2001;10:1137-44.
57. Bosron, WF and Li, TK. Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology 1986;6:502-10.
58. Coutelle C, Ward PJ, Fleury B, Quattrochi P, Chambrin H, Iron A, et al. Laryngeal and oropharyngeal cancer and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphism. Hum Genet 1997;99:319-25.
59. Bouchardy C, Hirvone A, Coutelle C, Ward P, Dayer P, Benhamou S. Role of alcohol dehydrogenasa 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract. Int J Cancer 2000; 87:734-40.
60. Olshan A, Weissler M, Watson M, Bell D. Risk of head and neck cancer and the alcohol dehydrogenase 3 genotype. Carcinogenesis 2001;22:57-61.
61. Watanabe J, Hayashi S, Kawajari K. Different regulation and expression of the human CYP2E1 gene due to the RsaI polymorphism in the 5′-flanking region. J. Biochem (Tokio) 1994;116:321-6.
62. Väkeväinen S, Tillonen J, Agarwal D, Srivastana N, Salaspuro M. High salivary acetaldehyde after a moderate dose of alcohol in ALDH-2 deficient subjects: strong evidence for the local carcinogenic action of acetaldehyde. Alcohol Clin Exp Res 2000;24:873-7.
63. Contreras EG, Bagán JV, Gavaldá C, Torres F. Retinoides: su aplicación en las lesiones precancerosas y el cáncer oral. Medicina Oral 2001;6:114-23.
64. Seitz H. Alcohol and retinoid metabolism. GUT 2000;47:748-50.
65. Duester G. Genetic dissection of enzimes control retinoid signalling during development, en http://www.burnham.org/reports/4.duester.97.html.
66. Blot W. Alcohol and cancer. Cancer research 1992;1:2119-23.
67. Marshall J, Boyle P. Nutrition and oral cancer. Cancer causes and control 1996;7:101-11.
68. Simanowski UA, Suter P, Stickel F, Maier H, Waldherr R, Smith D, et al. Esophageal epithelial hyperproliferation following long-term alcohol consumption in rats: effects of age and salivary gland function. J Nat Cancer Institut 1993;85:2030-3.
69. Dutta SK, Orestes M, Vengulekur S, Kwo P. Ethanol and human saliva: effect of chronic alcoholism on flow rate, composition, and epidermal growth factor. Am J Gastroenterol 1992;87:350-4.
70. Ogden GR, Wight AJ, Rice P. Effect of alcohol on the oral mucosa assessed by quantitative cytomorphmetry. J Oral Pathol Med 1999;28:216-20.
71. Barret AW, Williams D, Scott J. Effect of tobacco and alcohol consumption on the langerhans cell population of human lingual epithelium determined using a monoclonal antibody against HLADR. J Oral Pathol Med 1991;20:49-52.
72. Du X, Squier CA, Kremer MJ, Wertz PW. Penetration on N-nitrosonornicotine (NNN) across oral mucosa in the presence of ethanol and nicotine. J Oral Pathol Med 2000;29:80-5.
73. Jovanovic A, Schulten E, Kostense P, Snow GB, Van der Waal I. Tobacco and alcohol related to the anatomical site of oral squamous cell carcinoma. J Oral Pathol Med 1993;22:459-62.
74. Khan FA, Robinson PG, Warnakulasuriya K, Newton J, Gelbier S, Gibbons D. Predictors of tobacco and alcohol and their relevance to oral cancer controls amongst people in the south Thames health region. England. J Oral Pathol Med 2000;29:214-9.
75. Llewelyn J, Mitchell, R. Smoking, alcohol and oral cancer in South East Scotland: a 10-year experience. British J of Oral & Maxilofac Surg. 1994; 32:146-52.
76. Summerlin D, Dunipace A, Potter R. Histologic effects of smokeless tobacco and alcohol on the pouch mucosa and organs of the Syrian hamster. J Oral Patholo Med 1992;21:105-8.
77. Weaver A, Fleming S, Smith D. Mouthwah and oral cancer: carcinogen or coincidence?. J Oral Surgery 1979;73:250-3.
78. Harris E. Association of oral cancers with alcohol consumption: exploring mechanisms. J Nat Cancer Instit 1997;89:1656-7.
79. Squier CA, Cox P, Hall BK. Ethanol penetration of nitrosonornicotine across oral mucosa in the presence of ethanol. J Oral Pathol 1986;15:276-9.