Intrathecal injection of spironolactone attenuates radicular pain by inhibition of spinal microglia activation in a rat model

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Sun, Yu e ^a   Peng, Liangyu ^a   Sun, Xiaofeng ^a   Bo, Jinhua ^a   Yang, Dong ^a   Zheng, Yaguo ^a   Liu, Chenglong ^a   Zhu, Beibei ^a   Ma, Zhengliang ^a   Gu, Xiaoping ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; MINOCYCLINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; SERINE; SPIRONOLACTONE; TUMOR NECROSIS FACTOR ALPHA;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; GLIA CELL; INHIBITION KINETICS; MALE; MICROGLIA; NERVE COMPRESSION; NONHUMAN; PAIN THRESHOLD; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADICULAR PAIN; RAT; SPINAL CORD DORSAL HORN; SPINAL GANGLION; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CYTOKINES; DISEASE MODELS, ANIMAL; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; INFLAMMATION MEDIATORS; INJECTIONS, SPINAL; MALE; MICROGLIA; PAIN; PHOSPHORYLATION; POSTERIOR HORN CELLS; RADICULOPATHY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; SPIRONOLACTONE;

RATTUS;

EID: 84863088861     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039897     Document Type: Article

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