Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: The preventive effect of ketamine

Molecular Pain

Volumn 5, Issue , 2009, Pages

  Gu, Xiaoping ^a   Wu, Xiaoli ^a   Liu, Yue ^a   Cui, Songqin ^a   Ma, Zhengliang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RECEPTOR BLOCKING AGENT; AUTACOID; GLUTAMIC ACID; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NARCOTIC ANALGESIC AGENT; NR2B NMDA RECEPTOR; PIPERIDINE DERIVATIVE; REMIFENTANIL; TYROSINE;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; HYPERALGESIA; MALE; METABOLISM; NOCICEPTIVE RECEPTOR; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; POSTOPERATIVE PAIN; RAT; SPINAL CORD; SPRAGUE DAWLEY RAT; SYNAPTIC TRANSMISSION;

ANALGESICS, OPIOID; ANIMALS; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HYPERALGESIA; INFLAMMATION MEDIATORS; KETAMINE; MALE; NOCICEPTORS; PAIN, POSTOPERATIVE; PHOSPHORYLATION; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; SYNAPTIC TRANSMISSION; TYROSINE;

EID: 77649285188     PISSN: None     EISSN: 17448069     Source Type: Journal    
DOI: 10.1186/1744-8069-5-76     Document Type: Article

References (42)

1. Li X, Angst MS, Clark JD. Opioid-induced hyperalgesia and incisional pain. Anesth Analg 2001, 93:204-209. 10.1097/00000539-200107000-00040, 11429366.
2. Derrode N, Lebrun F, Levron JC, Chauvin M, Debaene B. Influence of perioperative opioid on postoperative pain after major abdominal surgery: Sufentanil TCI versus remifentanil TCI. A randomized, controlled study. Br J Anaesth 2003, 91:842-849. 10.1093/bja/aeg263, 14633756.
3. Joly V, Richebe P, Guiqnard B, Fletcher D, Maurette P, Sessler DI, Chauvin M. Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine. Anesthesiology 2005, 103:147-155. 10.1097/00000542-200507000-00022, 15983467.
4. Angst MS, Koppert W, Pahl I, Clark DJ, Schmelz M. Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawl. Pain 2003, 106:49-57. 10.1016/S0304-3959(03)00276-8, 14581110.
5. Woolf CJ, Thompson SW. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain 1991, 44:293-299. 10.1016/0304-3959(91)90100-C, 1828878.
6. Guntz E, Dumont H, Roussel C, Gall D, Dufrasne F, Cuvelier L, Blum D, Schiffmann SN, Sosnowski M. Effects of remifentanil on N-methyl-D-aspartate receptor: an electrophysiologic study in rat spinal cord. Anesthesiology 2005, 102:1235-1241. 10.1097/00000542-200506000-00025, 15915038.
7. Zhao M, Joo DT. Enhancement of spinal N-methyl-D-aspartate receptor function by remifentanil action at delta-opioid receptors as a mechanism for acute opioid-induced hyperalgesia or tolerance. Anesthesiology 2008, 109:308-317. 10.1097/ALN.0b013e31817f4c5d, 18648240.
8. Mori H, Mishina M. Structure and function of the NMDA receptor channel. Neuropharmacology 1995, 34:1219-1237. 10.1016/0028-3908(95)00109-J, 8570021.
9. Boyce S, Wyatt A, Webb JK, O'Donnell R, Mason G, Riqby M, Sirinathsinqhji D, Hill RG, Rupniak NM. Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn. Neuropharmacology 1999, 38:611-623. 10.1016/S0028-3908(98)00218-4, 10340299.
10. Zhang W, Shi CX, Gu XP, Ma ZL, Zhu W. Ifenprodil Induced Antinociception and Decreased the Expression of NR2B Subunits in the Dorsal Horn After Chronic Dorsal Root Ganglia Compression in Rats. Anesth Analg 2009, 108:1015-1020. 10.1213/ane.0b013e318193ffd2, 19224818.
11. Gu X, Zhang J, Ma Z, Wang J, Zhou X, Jin Y, Xia X, Gao Q, Mei F. The role of N-methyl-d-aspartate receptor subunit NR2B in spinal cord in cancer pain. Eur J Pain
12. Moon IS, Apperson ML, Kennedy MB. The major tyrosinephosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B. Proc Natl Acad Sci USA 1994, 91:3954-3958. 10.1073/pnas.91.9.3954, 43701, 7513428.
13. Rosenblum K, Dudai Y. Long-term potentiation increases tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit 2B in rat dentate gyrus in vivo. Proc Natl Acad Sci USA 1996, 93:10457-10460. 10.1073/pnas.93.19.10457, 38406, 8816822.
14. Rostas JA, Brent VA, Voss K, Errington ML, Bliss TV, Gurd JW. Enhanced tyrosine phosphorylation of the 2B subunit of the N-methyl-D-aspartate receptor in long-term potentiation. Proc Natl Acad Sci USA 1996, 93:10452-10456. 10.1073/pnas.93.19.10452, 38405, 8816821.
15. Guo W, Wei F, Zou S, Robbins MT, Sugiyo S, Ikeda T, Tu JC, Worley PF, Dubner R, Ren K. Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia. J Neurosci 2004, 24:9161-9173. 10.1523/JNEUROSCI.3422-04.2004, 15483135.
16. Hirota K, Lambert DG. Ketamine: Its mechanism(s) of action and unusual clinical uses. Br J Anaesth 1996, 77:441-444.
17. Orser BA, Pennefather PS, MacDonald JF. Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors. Anesthesiology 1997, 86:903-917. 10.1097/00000542-199704000-00021, 9105235.
18. Célèrier E, Rivat C, Jun Y, Laulin JP, Larcher A, Reynier P, Simonnet G. Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine. Anesthesiology 2000, 92:465-472. 10.1097/00000542-200002000-00029, 10691234.
19. Richebe P, Rivat C, Laulin JP, Maurette P, Simonnet G. Ketamine improves the management of exaggerated postoperative pain observed in perioperative fentanyl-treated rats. Anesthesiology 2005, 102:421-428. 10.1097/00000542-200502000-00028, 15681961.
20. Van Elstraete AC, Sitbon P, Trabold F, Mazoit JX, Benhamou D. A single dose of intrathecal morphine in rats induces long-lasting hyperalgesia: the protective effect of prior administration of ketamine. Anesth Analg 2005, 101:1750-1756. 10.1213/01.ANE.0000184136.08194.9B, 16301254.
21. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16:109-110. 10.1016/0304-3959(83)90201-4, 6877845.
22. Brennan TJ, Vandermeulen EP, Gebhart GF. Characterization of a rat model of incisional pain. Pain 1996, 64:493-501. 10.1016/0304-3959(95)01441-1, 8783314.
23. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994, 53:55-63. 10.1016/0165-0270(94)90144-9, 7990513.
24. Lozito RJ, La Marca S, Dunn RW, Jerussi TP. Single versus multiple infusions of fentanyl analogues in a rat EEG model. Life Sci 1994, 55:1337-1342. 10.1016/0024-3205(94)00766-7, 7934641.
25. Célérier E, González JR, Maldonado R, Cabañero D, Puig MM. Opioid-induced hyperalgesia in a murine model of postoperative pain: role of nitric oxide generated from the inducible nitric oxide synthase. Anesthesiology 2006, 104:546-555. 10.1097/00000542-200603000-00023, 16508403.
26. Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 1993, 52:259-285. 10.1016/0304-3959(93)90161-H, 7681556.
27. Coderre TJ, Melzack R. Increased pain sensitivity following heat injury involves a central mechanism. Behav Brain Res 1985, 15:259-262. 10.1016/0166-4328(85)90181-0, 4005034.
28. Yu XM, Askalan R, Keil GJ, Salter MW. NMDA channel regulation by channel-associated protein tyrosine kinase Src. Science 1997, 275:674-678. 10.1126/science.275.5300.674, 9005855.
29. Tezuka T, Umemori H, Akiyama T, Nakanishi S, Yamamoto T. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc Natl Acad Sci USA 1999, 96:435-440. 10.1073/pnas.96.2.435, 15154, 9892651.
30. Guo W, Zou S, Guan Y, Ikeda T, Tal M, Dubner R, Ren K. Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia. J Neurosci 2002, 22:6208-6217.
31. Nakazawa T, Komai S, Tezuka T, Hisatsune C, Umemori H, Semba K, Mishina M, Manabe T, Yamamoto T. Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor. J Biol Chem 2001, 276:693-699. 10.1074/jbc.M008085200, 11024032.
32. Drdla R, Gassner M, Gingl E, Sandkühler J. Induction of synaptic long-term potentiation after opioid withdrawal. Science 2009, 325:207-210. 10.1126/science.1171759, 19590003.
33. Abe T, Matsumura S, Katano T, Mabuchi T, Takagi K, Xu L, Yamamoto A, Hattori K, Yagi T, Watanabe M, Nakazawa T, Yamamoto T, Mishina M, Nakai Y, Ito S. Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. Eur J Neurosci 2005, 22:1445-1454. 10.1111/j.1460-9568.2005.04340.x, 16190898.
34. Rivat C, Laulin JP, Corcuff JB, Célèrier E, Pain L, Simonnet G. Fentanyl enhancement of carrageenan-induced long-lasting hyperalgesia in rats: prevention by the N-methyl-D-aspartate receptor antagonist ketamine. Anesthesiology 2002, 96:381-391. 10.1097/00000542-200202000-00025, 11818772.
35. Johnson JW, Ascher P. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 1987, 325:529-531. 10.1038/325529a0, 2433595.
36. Engelhardt T, Zaarour C, Naser B, Pehora C, de Ruiter J, Howard A, Crawford MW. Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery. Anesth Analg 2008, 107:1170-1175. 10.1213/ane.0b013e318183919e, 18806023.
37. Wilson JA, Garry EM, Anderson HA, Rosie R, Colvin LA, Mitchell R, Fleetwood-Walker SM. NMDA receptor antagonist treatment at the time of nerve injury prevents injury-induced changes in spinal NR1 and NR2B subunit expression and increases the sensitivity of residual pain behaviours to subsequently administered NMDA receptor antagonists. Pain 2005, 117:421-432. 10.1016/j.pain.2005.07.005, 16150544.
38. Heinke B, Balzer E, Sandkühler J. Pre- and postsynaptic contributions of voltage-dependent Ca2+ channels to nociceptive transmission in rat spinal lamina I neurons. Eur J Neurosci 2004, 19:103-111. 10.1046/j.1460-9568.2003.03083.x, 14750968.
39. Matthews EA, Dickenson AH. Effects of spinally delivered N- and P-type voltage-dependent calcium channel antagonists on dorsal horn neuronal responses in a rat model of neuropathy. Pain 2001, 92:235-246. 10.1016/S0304-3959(01)00255-X, 11323145.
40. Kohrs R, Durieux ME. Ketamine: teaching an old drug new tricks. Anesth Analg 1998, 87:1186-1193. 10.1097/00000539-199811000-00039, 9806706.
41. Koizuka S, Obata H, Sasaki M, Saito S, Goto F. Systemic ketamine inhibits hypersensitivity after surgery via descending inhibitory pathways in rats. Can J Anaesth 2005, 52:498-505. 10.1007/BF03016530, 15872129.
42. Pekoe GM, Smith DJ. The involvement of opiate and monoaminergic neuronal systems in the analgesic effects of ketamine. Pain 1982, 12:57-73. 10.1016/0304-3959(82)90170-1, 7058060.