Anti-inflammatory effects of levetiracetam in experimental autoimmune encephalomyelitis

International Immunopharmacology

Volumn 14, Issue 1, 2012, Pages 9-12

  Thöne, Jan ^a   Ellrichmann, Gisa ^a   Faustmann, Pedro M ^b   Gold, Ralf ^a   Haghikia, Aiden ^a  

^a ST JOSEF HOSPITAL   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

EAE; IL 1beta; Immunomodulation; Multiple sclerosis; TGF beta

Indexed keywords

ETIRACETAM; INTERLEUKIN 1BETA; TRANSFORMING GROWTH FACTOR BETA1;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL COUNT; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; DOSE RESPONSE; DRUG DOSE COMPARISON; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GENE EXPRESSION REGULATION; IMMUNOMODULATION; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; MULTIPLE SCLEROSIS; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; NEUROGLIA; PEPTIDE FRAGMENTS; PIRACETAM; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84863087140     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.05.021     Document Type: Article

References (16)

1. A.Z. Crepeau, and D.M. Treiman Levetiracetam: a comprehensive review Expert Rev Neurother 10 2010 159 171
2. R. Surges, K.E. Volynski, and M.C. Walker Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited Ther Adv Neurol Disord 1 2008 13 24
3. J.E. Kim, H.C. Choib, H.K. Song, S.M. Jo, D.S. Kim, and S.Y. Choi Levetiracetam inhibits interleukin-1β inflammatory responses in the hippocampus and piriform cortex of epileptic rats Neurosci Lett 471 2010 94 99
4. A. Haghikia, K. Ladage, D. Hinkerohe, P. Vollmar, K. Heupel, and R. Dermietzel Implications of antiinflammatory properties of the anticonvulsant drug levetiracetam in astrocytes J Neurosci Res 86 2008 1781 1788 (Pubitemid 351859428)
5. M.N. Stienen, A. Haghikia, H. Dambach, J. Thöne, M. Wiemann, and R. Gold Anti-inflammatory effects of the anticonvulsant drug levetiracetam on electrophysiological properties of astroglia are mediated via TGFβ1 regulation Br J Pharmacol 162 2011 491 507
6. E. Bettelli, M. Oukka, and V.K. Kuchroo T(H)-17 cells in the circle of immunity and autoimmunity Nat Immunol 8 2007 345 350 (Pubitemid 46745409)
7. T.V. Lanz, Z. Ding, P.P. Ho, J. Luo, A.N. Agrawal, and H. Srinagesh Angiotensin II sustains brain inflammation in mice via TGF-beta J Clin Invest 120 2010 2782 2794
8. P. Ehling, S. Bittner, T. Budde, H. Wiendl, and S.G. Meuth Ion channels in autoimmune neurodegeneration FEBS Lett 585 2011 3836 3842
9. J.A. Black, S. Liu, M. Carrithers, L.M. Carrithers, and S.G. Waxmann Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepine Ann Neurol 62 2007 21 33 (Pubitemid 47235277)
10. V. Cardile, A. Pavone, R. Gulino, M. Renis, C. Scifo, and V. Perciavalle Expression of brain-derived neurotrophic factor (BDNF) and inducible nitric oxide synthase (iNOS) in rat astrocytes cultures treated with levetiracetam Brain Res 976 2003 227 233 (Pubitemid 36570459)
11. J. Thöne, G. Ellrichmann, S. Seubert, I. Peruga, D.H. Lee, and R. Conrad Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor Am J Pathol 180 2012 267 274
12. R. Gold, C. Linington, and H. Lassmann Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research Brain 129 2006 1953 1971 (Pubitemid 44289062)
13. R.A. Linker, M. Mäurer, S. Gaupp, R. Martini, R.B. Holtmann, and R. Giess CNTF is a major protective factor in demyelinating CNS disease: a neurotrophic cytokine as modulator in neuroinflammation Nat Med 8 2002 620 624 (Pubitemid 34633441)
14. J.J. Luszczki, M.M. Andres, P. Czuczwar, A. Cioczek-Czuczwar, J. Wokcik-Cwikla, and N. Ratnaraj Levetiracetam selectively potentiates the acute neurotoxic effects of topiramate and carbamazepine in the rotarod test in mice Eur Neuropsychopharmacol 15 2005 609 616 (Pubitemid 41587411)
15. M. Stettner, T. Dehmel, A.K. Mausberg, A. Köhne, C.R. Rose, and B.C. Kieseier Levetiracetam exhibits protective properties on rat Schwann cells in vitro J Peripher Nerv Syst 16 2011 250 260
16. K.V. Christensen, H. Leffers, W.P. Watson, C. Sánchez, P. Kallunki, and J. Egebjerg Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats BMC Neurosci 11 2010 9