Levetiracetam inhibits interleukin-1β inflammatory responses in the hippocampus and piriform cortex of epileptic rats

Neuroscience Letters

Volumn 471, Issue 2, 2010, Pages 94-99

  Kim, Ji Eun ^a   Choi, Hui Chul ^a   Song, Hong Ki ^a   Jo, Seung Mook ^b   Kim, Duk Soo ^c   Choi, Soo Young ^a   Kim, Yeong In ^a,d   Kang, Tae Cheon ^a  

^a Hallym University   (South Korea)

^b Gachon University   (South Korea)

^c Soonchunhyang University   (South Korea)

^d The Catholic University of Korea   (South Korea)

Author keywords

Astroglia; Epilepsy; Gliogenesis; Hippocampus; IL 1 ; Levetiracetam; Microglia; Piriform cortex

Indexed keywords

ETIRACETAM; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTOSIS; BRAIN REGION; CHRONIC DISEASE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; EPILEPTIC STATE; GLIOSIS; HIPPOCAMPUS; IMMUNOREACTIVITY; INFLAMMATORY DISEASE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRIFORM CORTEX; RAT;

ANIMALS; ANTICONVULSANTS; ASTROCYTES; CHRONIC DISEASE; EPILEPSY; GLIOSIS; HIPPOCAMPUS; INTERLEUKIN-1BETA; MALE; MICROGLIA; OLFACTORY PATHWAYS; PILOCARPINE; PIRACETAM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, INTERLEUKIN-1 TYPE I; VALPROIC ACID;

EID: 75949084962     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.01.018     Document Type: Article

References (23)

1. Ali D.W., and Salter M.W. NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity. Curr. Opin. Neurobiol. 11 (2001) 336-342
2. Allan S.M., and Rothwell N.J. Cytokines and acute neurodegeneration. Nat. Rev. Neurosci. 2 (2001) 734-744
3. An S.J., Park S.K., Hwang I.K., Choi S.Y., Kwon O.S., Won M.H., and Kang T.C. Vigabatrin inhibits pyridoxine-5′-phosphate oxidase, not pyridoxal kinase in the hippocampus of seizure prone gerbils. Neurochem. Int. 44 (2004) 133-137
4. Casamenti F., Prosperi C., Scali C., Giovannelli L., Colivicchi M.A., Faussone-Pellegrini M.S., and Pepeu G. Interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer's disease. Neuroscience 91 (1999) 831-842
5. De Simoni M.G., Perego C., Ravizza T., Moneta D., Conti M., Marchesi F., De Luigi A., Garattini S., and Vezzani A. Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus. Eur. J. Neurosci. 12 (2000) 2623-2633
6. Dinarello C.A. The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome. J. Infect. Dis. 163 (1991) 1177-1184
7. Dubé C., Vezzani A., Behrens M., Bartfai T., and Baram T.Z. Interleukin-1beta contributes to the generation of experimental febrile seizures. Ann. Neurol. 57 (2005) 152-155
8. Emerson M.R., Nelson S.R., Samson F.E., and Pazdernik T.L. Hypoxia preconditioning attenuates brain edema associated with kainic acid-induced status epilepticus in rats. Brain Res. 825 (1999) 189-193
9. Fuks B., Gillard M., Michel P., Lynch B., Vertongen P., Leprince P., Klitgaard H., and Chatelain P. Localization and photoaffinity labelling of the levetiracetam binding site in rat brain and certain cell lines. Eur. J. Pharmacol. 478 (2003) 11-19
10. Haghikia A., Ladage K., Hinkerohe D., Vollmar P., Heupel K., Dermietzel R., and Faustmann P.M. Implications of antiinflammatory properties of the anticonvulsant drug levetiracetam in astrocytes. J. Neurosci. Res. 86 (2008) 1781-1788
11. Hanon E., and Klitgaard H. Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia. Seizure 10 (2001) 287-293
12. Hu S., Sheng W.S., Ehrlich L.C., Peterson P.K., and Chao C.C. Cytokine effects on glutamate uptake by human astrocytes. Neuroimmunomodulation 7 (2000) 153-159
13. Kang T.C., An S.J., Park S.K., Hwang I.K., Bae J.C., and Won M.H. Changed vesicular GABA transporter immunoreactivity in the gerbil hippocampus following spontaneous seizure and vigabatrin administration. Neurosci. Lett. 335 (2003) 207-211
14. Kielian T. Glial connexins and gap junctions in CNS inflammation and disease. J. Neurochem. 106 (2008) 1000-1016
15. Loddick S.A., and Rothwell N.J. Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. J. Cereb. Blood Flow Metab. 16 (1996) 932-940
16. Löscher W., Hönack D., and Rundfeldt C. Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. J. Pharmacol. Exp. Ther. 284 (1998) 474-479
17. McGraw J., Hiebert G.W., and Steeves J.D. Modulating astrogliosis after neurotrauma. J. Neurosci. Res. 63 (2001) 109-115
18. Minami M., Kuraishi Y., and Satoh M. Effects of kainic acid on messenger RNA levels of IL-1 beta, IL-6, TNF alpha and LIF in the rat brain. Biochem. Biophys. Res. Commun. 176 (1991) 593-598
19. Rizzi M., Perego C., Aliprandi M., Richichi C., Ravizza T., Colella D., Velískǒvá J., Moshé S.L., De Simoni M.G., and Vezzani A. Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development. Neurobiol. Dis. 14 (2003) 494-503
20. Vezzani A., Conti M., De Luigi A., Ravizza T., Moneta D., Marchesi F., and De Simoni M.G. Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures. J. Neurosci. 19 (1999) 5054-5065
21. Vezzani A., Moneta D., Conti M., Richichi C., Ravizza T., De Luigi A., De Simoni M.G., Sperk G., Andell-Jonsson S., Lundkvist J., Iverfeldt K., and Bartfai T. Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 11534-11539
22. Viviani B., Bartesaghi S., Gardoni F., Vezzani A., Behrens M.M., Bartfai T., Binaglia M., Corsini E., Di Luca M., Galli C.L., and Marinovich M. Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J. Neurosci. 23 (2003) 8692-8700
23. Ye Z.C., and Sontheimer H. Cytokine modulation of glial glutamate uptake: a possible involvement of nitric oxide. Neuroreport 7 (1996) 2181-2185