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Volumn 6, Issue 1, 2012, Pages 5-10

On how CCN6 suppresses breast cancer growth and invasion

Author keywords

Breast cancer; CCN6; Epithelial to mesenchymal transition; Inflammatory breast cancer; Insulin like growth factor; WISP3

Indexed keywords

CCN PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN CCN6; SOMATOMEDIN C; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 84863085243     PISSN: 18739601     EISSN: 1873961X     Source Type: Journal    
DOI: 10.1007/s12079-011-0148-9     Document Type: Article
Times cited : (12)

References (43)
  • 4
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    • Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, Shannon MF et al (2008) A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res 68:7846-7854
    • (2008) Cancer Res , vol.68 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3    Bert, A.G.4    Wang, J.5    Shannon, M.F.6
  • 5
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • DOI 10.1038/embor.2008.74, PII EMBOR200874
    • Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S et al (2008) A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 9:582-589 (Pubitemid 351772923)
    • (2008) EMBO Reports , vol.9 , Issue.6 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3    Schmalhofer, O.4    Vincan, E.5    Spaderna, S.6    Brabletz, T.7
  • 6
    • 0034660884 scopus 로고    scopus 로고
    • Plasma insulin-like growth factor (IGF) I, IGF-binding protein 3, and mammographic density
    • Byrne C, Colditz GA, Willett WC, Speizer FE, Pollak M, Hankinson SE (2000) Plasma insulin-like growth factor (IGF) I, IGF-binding protein 3, and mammographic density. Cancer Res 60:3744-3748 (Pubitemid 32204562)
    • (2000) Cancer Research , vol.60 , Issue.14 , pp. 3744-3748
    • Byrne, C.1    Colditz, G.A.2    Willet, W.C.3    Speizer, F.E.4    Pollak, M.5    Hankinson, S.E.6
  • 8
    • 8244259928 scopus 로고    scopus 로고
    • Loss of heterozygosity at chromosome 6q in preinvasive and early invasive breast carcinomas
    • Chappell SA, Walsh T, Walker RA, Shaw JA (1997) Loss of heterozygosity at chromosome 6q in preinvasive and early invasive breast carcinomas. Br J Cancer 75:1324-1329 (Pubitemid 27179823)
    • (1997) British Journal of Cancer , vol.75 , Issue.9 , pp. 1324-1329
    • Chapped, S.A.1    Walsh, T.2    Walker, R.A.3    Shaw, J.A.4
  • 9
    • 34249880476 scopus 로고    scopus 로고
    • What progress have we made in managing inflammatory breast cancer?
    • Dawood S, Cristofanilli M (2007) What progress have we made in managing inflammatory breast cancer? Oncology (Williston Park) 21:673-679, discussion 679-680, 686-677 (Pubitemid 46870370)
    • (2007) ONCOLOGY , vol.21 , Issue.6 , pp. 673-679
    • Dawood, S.1    Komen, S.G.2    Cristofanilli, M.3
  • 12
    • 20144388095 scopus 로고    scopus 로고
    • DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells
    • DOI 10.1038/sj.onc.1208429
    • Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M et al (2005) DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene 24:2375-2385 (Pubitemid 40546696)
    • (2005) Oncogene , vol.24 , Issue.14 , pp. 2375-2385
    • Eger, A.1    Aigner, K.2    Sonderegger, S.3    Dampier, B.4    Oehler, S.5    Schreiber, M.6    Berx, G.7    Cano, A.8    Beug, H.9    Foisner, R.10
  • 14
    • 0029879976 scopus 로고    scopus 로고
    • Detection of frequent allelic loss of 6q23-q25.2 in microdissected human breast cancer tissues
    • DOI 10.1002/(SICI)1098-2264(199605)16:1<35::AID-GCC5>3.0.CO;2-4
    • Fujii H, Zhou W, Gabrielson E (1996) Detection of frequent allelic loss of 6q23-q25.2 in microdissected human breast cancer tissues. Genes Chromosomes Cancer 16:35-39 (Pubitemid 26141252)
    • (1996) Genes Chromosomes and Cancer , vol.16 , Issue.1 , pp. 35-39
    • Fujii, H.1    Zhou, W.2    Gabrielson, E.3
  • 15
    • 42049092980 scopus 로고    scopus 로고
    • Insulin-like growth factor-I - Dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells
    • DOI 10.1158/0008-5472.CAN-07-2559
    • Graham TR, Zhau HE, Odero-Marah VA, Osunkoya AO, Kimbro KS, Tighiouart M et al (2008) Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer Res 68:2479-2488 (Pubitemid 351521824)
    • (2008) Cancer Research , vol.68 , Issue.7 , pp. 2479-2488
    • Graham, T.R.1    Zhau, H.E.2    Odero-Marah, V.A.3    Osunkoya, A.O.4    Kimbro, K.S.5    Tighiouart, M.6    Liu, T.7    Simons, J.W.8    O'Regan, R.M.9
  • 16
    • 18144380288 scopus 로고    scopus 로고
    • Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation
    • DOI 10.1096/fj.04-3217com
    • Grotendorst GR, Duncan MR (2005) Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation. FASEB J 19:729-738 (Pubitemid 40617377)
    • (2005) FASEB Journal , vol.19 , Issue.7 , pp. 729-738
    • Grotendorst, G.R.1    Duncan, M.R.2
  • 17
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70 (Pubitemid 30046295)
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 18
    • 42049085877 scopus 로고    scopus 로고
    • Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1
    • DOI 10.2353/ajpath.2008.070899
    • Huang W, Zhang Y, Varambally S, Chinnaiyan AM, Banerjee M, Merajver SD et al (2008) Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1. Am J Pathol 172:893-904 (Pubitemid 351519987)
    • (2008) American Journal of Pathology , vol.172 , Issue.4 , pp. 893-904
    • Huang, W.1    Zhang, Y.2    Varambally, S.3    Chinnaiyan, A.M.4    Banerjee, M.5    Merajver, S.D.6    Kleer, C.G.7
  • 19
    • 77951062010 scopus 로고    scopus 로고
    • Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells
    • Huang W, Gonzalez ME, Toy KA, Banerjee M, Kleer CG (2010) Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells. Cancer Res 70:3340-3350
    • (2010) Cancer Res , vol.70 , pp. 3340-3350
    • Huang, W.1    Gonzalez, M.E.2    Toy, K.A.3    Banerjee, M.4    Kleer, C.G.5
  • 22
    • 34147193818 scopus 로고    scopus 로고
    • Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-κB and snail
    • DOI 10.1128/MCB.01315-06
    • Kim HJ, Litzenburger BC, Cui X, Delgado DA, Grabiner BC, Lin X et al (2007) Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail. Mol Cell Biol 27:3165-3175 (Pubitemid 46581327)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.8 , pp. 3165-3175
    • Kim, H.-J.1    Litzenburger, B.C.2    Cui, X.3    Delgado, D.A.4    Grabiner, B.C.5    Lin, X.6    Lewis, M.T.7    Gottardis, M.M.8    Wong, T.W.9    Attar, R.M.10    Carboni, J.M.11    Lee, A.V.12
  • 23
    • 85047695306 scopus 로고    scopus 로고
    • WISP3 is a novel tumor suppressor gene of inflammatory breast cancer
    • DOI 10.1038/sj/onc/1205462
    • Kleer CG, Zhang Y, Pan Q, van Golen KL, Wu ZF, Livant D et al (2002) WISP3 is a novel tumor suppressor gene of inflammatory breast cancer. Oncogene 21:3172-3180 (Pubitemid 34552242)
    • (2002) Oncogene , vol.21 , Issue.20 , pp. 3172-3180
    • Kleer, C.G.1    Zhang, Y.2    Pan, Q.3    Van Golen, K.L.4    Wu, Z.-F.5    Livant, D.6    Merajver, S.D.7
  • 24
    • 2142646419 scopus 로고    scopus 로고
    • WISP3 (CCN6) Is a Secreted Tumor-Suppressor Protein that Modulates IGF Signaling in Inflammatory Breast Cancer
    • DOI 10.1593/neo.03316
    • Kleer CG, Zhang Y, Pan Q, Merajver SD (2004) WISP3 (CCN6) is a secreted tumor-suppressor protein that modulates IGF signaling in inflammatory breast cancer. Neoplasia 6:179-185 (Pubitemid 38544606)
    • (2004) Neoplasia , vol.6 , Issue.2 , pp. 179-185
    • Kleer, C.G.1    Zhang, Y.2    Pan, Q.3    Merajver, S.D.4
  • 25
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • Korpal M, Lee ES, Hu G, Kang Y (2008) The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 283:14910-14914
    • (2008) J Biol Chem , vol.283 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 27
    • 79956105716 scopus 로고    scopus 로고
    • CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer
    • Lorenzatti G, Huang W, Pal A, Cabanillas AM, Kleer CG (2011) CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer. J Cell Sci 124:1752-1758
    • (2011) J Cell Sci , vol.124 , pp. 1752-1758
    • Lorenzatti, G.1    Huang, W.2    Pal, A.3    Cabanillas, A.M.4    Kleer, C.G.5
  • 29
    • 62849087279 scopus 로고    scopus 로고
    • Mitochondrial DNA depletion in prostate epithelial cells promotes anoikis resistance and invasion through activation of PI3K/Akt2
    • Moro L, Arbini AA, Yao JL, di Sant'Agnese PA, Marra E, Greco M (2009) Mitochondrial DNA depletion in prostate epithelial cells promotes anoikis resistance and invasion through activation of PI3K/Akt2. Cell Death Differ 16:571-583
    • (2009) Cell Death Differ , vol.16 , pp. 571-583
    • Moro, L.1    Arbini, A.A.2    Yao, J.L.3    Di Sant'Agnese, P.A.4    Marra, E.5    Greco, M.6
  • 30
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • DOI 10.1101/gad.1640608
    • Park SM, Gaur AB, Lengyel E, Peter ME (2008) The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 22:894-907 (Pubitemid 351482843)
    • (2008) Genes and Development , vol.22 , Issue.7 , pp. 894-907
    • Park, S.-M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 31
    • 34249289041 scopus 로고    scopus 로고
    • Snail, ZEB and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • DOI 10.1038/nrc2131, PII NRC2131
    • Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7:415-428 (Pubitemid 46809165)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.6 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 32
    • 16544395386 scopus 로고    scopus 로고
    • Insulin-like growth factors and neoplasia
    • discussion 98-107, 265-108
    • Pollak MN (2004) Insulin-like growth factors and neoplasia. Novartis Found Symp 262:84-98, discussion 98-107, 265-108
    • (2004) Novartis Found Symp , vol.262 , pp. 84-98
    • Pollak, M.N.1
  • 33
    • 0033990756 scopus 로고    scopus 로고
    • At least five regions of imbalance on 6q in breast tumors, combining losses and gains
    • Rodriguez C, Causse A, Ursule E, Theillet C (2000) At least five regions of imbalance on 6q in breast tumors, combining losses and gains. Genes Chromosomes Cancer 27:76-84
    • (2000) Genes Chromosomes Cancer , vol.27 , pp. 76-84
    • Rodriguez, C.1    Causse, A.2    Ursule, E.3    Theillet, C.4
  • 34
    • 1042301373 scopus 로고    scopus 로고
    • A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells
    • DOI 10.1074/jbc.M305403200
    • Sachdev D, Hartell JS, Lee AV, Zhang X, Yee D (2004) A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells. J Biol Chem 279:5017-5024 (Pubitemid 38199098)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.6 , pp. 5017-5024
    • Sachdev, D.1    Hartell, J.S.2    Lee, A.V.3    Zhang, X.4    Yee, D.5
  • 35
    • 16844374390 scopus 로고    scopus 로고
    • Circulating levels of insulin-like growth factors, their binding proteins, and breast cancer risk
    • DOI 10.1158/1055-9965.EPI-04-0561
    • Schernhammer ES, Holly JM, Pollak MN, Hankinson SE (2005) Circulating levels of insulin-like growth factors, their binding proteins, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 14:699-704 (Pubitemid 40489217)
    • (2005) Cancer Epidemiology Biomarkers and Prevention , vol.14 , Issue.3 , pp. 699-704
    • Schernhammer, E.S.1    Holly, J.M.2    Pollak, M.N.3    Hankinson, S.E.4
  • 36
    • 68549106083 scopus 로고    scopus 로고
    • E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    • Schmalhofer O, Brabletz S, Brabletz T (2009) E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev 28:151-166
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 151-166
    • Schmalhofer, O.1    Brabletz, S.2    Brabletz, T.3
  • 37
    • 34548496683 scopus 로고    scopus 로고
    • Differential regulation of epithelial and mesenchymal markers by δEF1 proteins in epithelial-mesenchymal transition induced by TGF-β
    • DOI 10.1091/mbc.E07-03-0249
    • Shirakihara T, Saitoh M, Miyazono K (2007) Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta. Mol Biol Cell 18:3533-3544 (Pubitemid 47378691)
    • (2007) Molecular Biology of the Cell , vol.18 , Issue.9 , pp. 3533-3544
    • Shirakihara, T.1    Saitoh, M.2    Miyazono, K.3
  • 39
    • 0033838566 scopus 로고    scopus 로고
    • Function of the IGF-I receptor in breast cancer
    • Surmacz E (2000) Function of the IGF-I receptor in breast cancer. J Mammary Gland Biol Neoplasia 5:95-105
    • (2000) J Mammary Gland Biol Neoplasia , vol.5 , pp. 95-105
    • Surmacz, E.1
  • 42
    • 39649105682 scopus 로고    scopus 로고
    • Genetic determinants of aggressive breast cancer
    • DOI 10.1146/annurev.med.59.060106.184830
    • Ventura AC, Merajver SD (2008) Genetic determinants of aggressive breast cancer. Annu Rev Med 59:199-212 (Pubitemid 351287933)
    • (2008) Annual Review of Medicine , vol.59 , pp. 199-212
    • Ventura, A.C.1    Merajver, S.D.2
  • 43
    • 34447635028 scopus 로고    scopus 로고
    • Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells
    • Zhang Y, Pan Q, Zhong H, Merajver SD, Kleer CG (2005) Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells. Breast Cancer Research 7: R1080-R1089
    • (2005) Breast Cancer Research , vol.7
    • Zhang, Y.1    Pan, Q.2    Zhong, H.3    Merajver, S.D.4    Kleer, C.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.