The anti-metastatic efficacy of β-ionone and the possible mechanisms of action in human hepatocarcinoma SK-Hep-1 cells

British Journal of Nutrition

Volumn 107, Issue 5, 2012, Pages 631-638

  Huang, Chin Shiu ^a   Lyu, Shih Chieh ^b   Chen, Jen Yin ^c   Hu, Miao Lin ^b  

^a ASIA UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c CHI MEI MEDICAL CENTER   (Taiwan)

Author keywords

Ionone; Focal adhesion kinase; Metastasis; Nm23 H1; Rho GTPase

Indexed keywords

BETA IONONE; FOCAL ADHESION KINASE; GELATINASE A; GELATINASE B; NUCLEOSIDE DIPHOSPHATE KINASE A; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN CDC42; RAC1 PROTEIN; RHO FACTOR; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UROKINASE;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CELL ADHESION; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; METASTASIS INHIBITION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GELATINASES; HUMANS; LIVER NEOPLASMS; NEOPLASM PROTEINS; NM23 NUCLEOSIDE DIPHOSPHATE KINASES; NORISOPRENOIDS; PHOSPHORYLATION; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASES; UP-REGULATION; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 84863080430     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114511003473     Document Type: Article

References (45)

1. Ulisse S, Baldini E, Sorrenti S, et al. (2009) The urokinase plasminogen activator system: a target for anti-cancer therapy. Curr Cancer Drug Targets 9, 32-71.
2. Huang CS, Liao JW & Hu ML (2008) Lycopene inhibits experimental metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice. J Nutr 138, 538-543.
3. Yu YM, Lin HC & Chang WC (2008) Carnosic acid prevents the migration of human aortic smooth muscle cells by inhibiting the activation and expression of matrix metalloproteinase-. Br J Nutr 100, 731-738.
4. Cairns RA, Khokha R & Hill RP (2003) Molecular mechanisms of tumor invasion and metastasis: an integrated view. Curr Mol Med 3, 659-671. (Pubitemid 37236408)
5. Park SY, Lim SS, Kim JK, et al. (2010) Hexane-ethanol extract of Glycyrrhiza uralensis containing licoricidin inhibits the metastatic capacity of DU145 human prostate cancer cells. Br J Nutr 104, 1272-1282.
6. Blasi F (1997) uPA, uPAR, PAI-1: key intersection of proteolytic, adhesive and chemotactic highways? Immunol Today 18, 415-417. (Pubitemid 127773672)
7. Itoh T, Hayashi Y, Kanamaru T, et al. (2000) Clinical significance of urokinase-type plasminogen activator activity in hepatocellular carcinoma. J Gastroenterol Hepatol 15, 422-430. (Pubitemid 30262211)
8. Yam JW, Tse EY & Ng IO (2009) Role and significance of focal adhesion proteins in hepatocellular carcinoma. J Gastroenterol Hepatol 24, 520-530.
9. Zhao J & Guan JL (2009) Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev 28, 35-49.
10. Mon NN, Ito S, Senga T, et al. (2006) FAK signaling in neoplastic disorders: a linkage between inflammation and cancer. Ann N Y Acad Sci 1086, 199-212. (Pubitemid 47084387)
11. Mon NN, Hasegawa H, Thant AA, et al. (2006) A role for focal adhesion kinase signaling in tumor necrosis factoralpha- dependent matrix metalloproteinase-9 production in a cholangiocarcinoma cell line, CCKS1. Cancer Res 66, 6778-6784. (Pubitemid 44085637)
12. Etienne-Manneville S & Hall A (2002) Rho GTPases in cell biology. Nature 420, 629-635. (Pubitemid 36764489)
13. Huang CS, Shih MK, Chuang CH, et al. (2005) Lycopene inhibits cell migration and invasion and upregulates Nm23-H1 in a highly invasive hepatocarcinoma, SK-Hep-1 cells. J Nutr 135, 2119-2123.
14. Johnson IT (2007) Phytochemicals and cancer. Proc Nutr Soc 66, 207-215. (Pubitemid 46684974)
15. Bach TJ (1995) Some new aspects of isoprenoid biosynthesis in plants - a review. Lipids 30, 191-202.
16. Kim MO, Moon DO, Kang CH, et al. (2010) beta-Ionone enhances TRAIL-induced apoptosis in hepatocellular carcinoma cells through Sp1-dependent upregulation of DR5 and downregulation of NF-kappaB activity. Mol Cancer Ther 9, 833-843.
17. Cardozo MT, de Conti A, Ong TP, et al. (2011) Chemopreventive effects of b-ionone and geraniol during rat hepatocarcinogenesis promotion: distinct actions on cell proliferation, apoptosis, HMGCoA reductase, and RhoA. J Nutr Biochem 22, 130-135.
18. Mo H & Elson CE (1999) Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids. J Nutr 129, 804-813.
19. Liu JR, Sun XR, Dong HW, et al. (2008) beta-Ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley rat. Int J Cancer 122, 2689-2698.
20. Janakiram NB, Cooma I, Mohammed A, et al. (2008) Betaionone inhibits colonic aberrant crypt foci formation in rats, suppresses cell growth, and induces retinoid X receptor- alpha in human colon cancer cells. Mol Cancer Ther 7, 181-190.
21. Zhu J, Zhang L, Jin X, et al. (2010) beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. Mol Biol Rep 37, 2653-2663.
22. Sun X, Liu J, Sun W, et al. (2007) Beta-ionone induced apoptosis in SGC-7901 cells. Wei Sheng Yan Jiu 36, 667-670.
23. Lin JR, Chen BQ, Yang YM, et al. (2005) Inhibitory effect of potential metastasis in SGC-7901 cells induced by betaionone. Wei Sheng Yan Jiu 34, 435-438.
24. Phillips HJ (1973) Dye exclusion tests for cell viability. In Tissue Culture in Method and Applications, pp. 406-408. London: Academic Press.
25. Repesh LA (1989) A new in vitro assay for quantitating tumor cell invasion. Invas Metast 9, 192-208. (Pubitemid 19137195)
26. Yang CM, Liu YZ, Liao JW, et al. (2010) The in vitro and in vivo anti-metastatic efficacy of oxythiamine and the possible mechanisms of action. Clin Exp Metastasis 27, 341-349.
27. Yang HL, Kuo YH, Tsai CT, et al. (2011) Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway. Food Chem Toxicol 49, 290-298.
28. Yoon WH, Song IS, Lee BH, et al. (2004) Differential regulation of vimentin mRNA by 12-O-tetradecanoylphorbol 13-acetate and all-trans-retinoic acid correlates with motility of Hep 3B human hepatocellular carcinoma cells. Cancer Lett 203, 99-105.
29. Libra M, Scalisi A, Vella N, et al. (2009) Uterine cervical carcinoma: role of matrix metalloproteinases (review). Int J Oncol 34, 897-903.
30. Altadill A, Rodríguez M, González LO, et al. (2009) Liver expression of matrix metalloproteases and their inhibitors in hepatocellular carcinoma. Dig Liver Dis 41, 740-748.
31. Xia D, Yan LN, Xie JG, et al. (2006) Overexpression of TIMP-1 mediated by recombinant adenovirus in hepatocellular carcinoma cells inhibits proliferation and invasion in vitro. Hepatobiliary Pancreat Dis Int 5, 409-415. (Pubitemid 44295197)
32. Kawamata H, Kawai K, Kameyama S, et al. (1995) Overexpression of tissue inhibitor of matrix metalloproteinases (TIMP1 and TIMP2) suppresses extravasation of pulmonary metastasis of a rat bladder carcinoma. Int J Cancer 63, 680-687.
33. Schlaepfer DD, Hanks SK, Hunter T, et al. (1994) Integrinmediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372, 786-791.
34. Meng XN, Jin Y, Yu Y, et al. (2009) Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion. Br J Cancer 101, 327-334.
35. Liu JR, Yang YM, Dong HW, et al. (2005) Effect of betaionone in human mammary cancer cells (Er 2 ) by MAPK pathway. Wei Sheng Yan Jiu 34, 706-709.
36. Grise F, Bidaud A & Moreau V (2009) Rho GTPases in hepatocellular carcinoma. Biochim Biophys Acta 1795, 137-151.
37. Kim TY, Vigil D, Der CJ, et al. (2009) Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility. Cancer Metastasis Rev 28, 77-83.
38. Keely PJ, Westwick JK, Whitehead IP, et al. (1997) Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390, 632-636. (Pubitemid 28016201)
39. Guo W & Giancotti FG (2004) Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 5, 816-826. (Pubitemid 39336275)
40. Cheng S, Alfonso-Jaume MA, Mertens PR, et al. (2002) Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A transcription by interference with transactivator Y-box protein-1 (YB-1). Biochem J 366, 807-816.
41. Ohba K, Miyata Y, Koga S, et al. (2005) Expression of nm23- H1 gene product in sarcomatous cancer cells of renal cell carcinoma: correlation with tumor stage and expression of matrix metalloproteinase-2, matrix metalloproteinase-9, sialyl Lewis X, and c-erbB-2. Urology 65, 1029-1034. (Pubitemid 40693017)
42. Murakami M, Meneses PI, Lan K, et al. (2008) The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration. Cancer Biol Ther 7, 677-688.
43. Miyamoto M, Iwashita S, Yamaguchi S, et al. (2009) Role of nm23 in the regulation of cell shape and migration via Rho family GTPase signals. Mol Cell Biochem 329, 175-179.
44. Altucci L & Gronemeyer H (2001) The promise of retinoids to fight against cancer. Nat Rev Cancer 1, 181-193. (Pubitemid 33741893)
45. Xiao JH, Ghosn C, Hinchman C, et al. (2003) Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway. J Biol Chem 278, 29954-29962 (Pubitemid 36962384)