Aldosterone-induced brain MAPK signaling and sympathetic excitation are angiotensin II type-1 receptor dependent

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 302, Issue 3, 2012, Pages

  Zhang, Zhi Hua ^a   Yu, Yang ^a   Wei, Shun Guang ^a   Felder, Robert B ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b Affairs Medical Center   (United States)

Author keywords

Blood pressure; Extracellular related kinase 1 2; Hypothalamic paraventricular nucleus; Mineralocorticoid receptor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALDOSTERONE; ANGIOTENSIN 1 RECEPTOR; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE; OXPRENOATE POTASSIUM; PROTEIN P44; SMALL INTERFERING RNA;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HEART RATE; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MALE; MEAN ARTERIAL PRESSURE; NERVE EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ALDOSTERONE; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BLOOD PRESSURE; INFUSIONS, INTRAVENOUS; INFUSIONS, INTRAVENTRICULAR; LOSARTAN; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, MINERALOCORTICOID; RNA, SMALL INTERFERING; SYMPATHETIC NERVOUS SYSTEM;

EID: 84863076448     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00856.2011     Document Type: Article

References (38)

1. Brown NJ. Aldosterone and vascular inflammation. Hypertension 51: 161-167, 2008.
2. Chan SH, Hsu KS, Huang CC, Wang LL, Ou CC, Chan JY. NADPH oxidase-derived superoxide anion mediates angiotensin II-induced pressor effect via activation of p38 mitogen-activated protein kinase in the rostral ventrolateral medulla. Circ Res 97: 772-780, 2005.
3. Felder RB. Mineralocorticoid receptors, inflammation and sympathetic drive in a rat model of systolic heart failure. Exp Physiol 95: 19-25, 2010.
4. Felder RB, Yu Y, Zhang ZH, Wei SG. Pharmacological treatment for heart failure: a view from the brain. Clin Pharmacol Ther 86: 216-220, 2009.
5. Francis J, Weiss RM, Wei SG, Johnson AK, Beltz TG, Zimmerman K, Felder RB. Central mineralocorticoid receptor blockade improves volume regulation and reduces sympathetic drive in heart failure. Am J Physiol Heart Circ Physiol 281: H2241-H2251, 2001.
6. Funder JW. Minireview: aldosterone and mineralocorticoid receptors: past, present, and future. Endocrinology 151: 5098-5102, 2010.
7. Garrido AM, Griendling KK. NADPH oxidases and angiotensin II receptor signaling. Mol Cell Endocrinol 302: 148-158, 2009.
8. +-exchange in MDCK cells by aldosterone involves MAP-kinase ERK1/2. Pflügers Arch 441: 781-786, 2001.
9. Gomez-Sanchez EP. Central hypertensive effects of aldosterone. Front Neuroendocrinol 18: 440-462, 1997.
10. Gomez-Sanchez EP, Gomez-Sanchez CE. Central regulation of blood pressure by the mineralocorticoid receptor. Mol Cell Endocrinol 2011 Jun 1. [Epub ahead of print].
11. Gomez-Sanchez EP, Zhou M, Gomez-Sanchez CE. Mineralocorticoids, salt and high blood pressure. Steroids 61: 184-188, 1996.
12. Grossmann C, Benesic A, Krug AW, Freudinger R, Mildenberger S, Gassner B, Gekle M. Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions. Mol Endocrinol 19: 1697-1710, 2005.
13. Grossmann C, Gekle M. New aspects of rapid aldosterone signaling. Mol Cell Endocrinol 308: 53-62, 2009.
14. + channels prevents sympathetic hyperactivity and improves cardiac function in rats post-MI. Am J Physiol Heart Circ Physiol 288: H2491-H2497, 2005.
15. Huang BS, Leenen FH. Mineralocorticoid actions in the brain and hypertension. Curr Hypertens Rep 13, 214-220, 2011.
16. Kang YM, Ma Y, Elks C, Zheng JP, Yang ZM, Francis J. Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappaB. Cardiovasc Res 79: 671-678, 2008.
17. Kang YM, Zhang ZH, Johnson RF, Yu Y, Beltz T, Johnson AK, Weiss RM, Felder RB. Novel effect of mineralocorticoid receptor antagonism to reduce proinflammatory cytokines and hypothalamic activation in rats with ischemia-induced heart failure. Circ Res 99: 758-766, 2006.
18. Kiyomoto H, Rafiq K, Mostofa M, Nishiyama A. Possible underlying mechanisms responsible for aldosterone and mineralocorticoid receptor-dependent renal injury. J Pharm Sci 108: 399-405, 2008.
19. Lemarie CA, Paradis P, Schiffrin EL. New insights on signaling cascades induced by cross-talk between angiotensin II and aldosterone. J Mol Med 86: 673-678, 2008.
20. McEneaney V, Harvey BJ, Thomas W. Aldosterone rapidly activates protein kinase D via a mineralocorticoid receptor/EGFR trans-activation pathway in the M1 kidney CCD cell line. J Steroid Biochem Mol Biol 107: 180-190, 2007.
21. Morgan MJ, Liu ZG. Reactive oxygen species in TNFalpha-induced signaling and cell death. Mol Cell 30: 1-12, 2010.
22. Paxinos G, Watson C. The Rat Brain is Stereotaxic Coordinates. Sydney, Australia: Academic, 1986.
23. Rautureau Y, Paradis P, Schiffrin EL. Cross-talk between aldosterone and angiotensin signaling in vascular smooth muscle cells. Steroids 76: 834-839, 2011.
24. Torres M, Forman HJ. Redox signaling and the MAP kinase pathways. Biofactors 17: 287-296, 2003.
25. Wei SG, Felder RB. Forebrain renin-angiotensin system has a tonic excitatory influence on renal sympathetic nerve activity. Am J Physiol Heart Circ Physiol 282: H890-H895, 2002.
26. Wei SG, Yu Y, Zhang ZH, Felder RB. Angiotensin II upregulates hypothalamic AT1 receptor expression in rats via the mitogen-activated protein kinase pathway. Am J Physiol Heart Circ Physiol 296: H1425-H1433, 2009.
27. Wei SG, Yu Y, Zhang ZH, Weiss RM, Felder RB. Angiotensin II-triggered p44/42 mitogen-activated protein kinase mediates sympathetic excitation in heart failure rats. Hypertension 52: 342-350, 2008.
28. Wei SG, Yu Y, Zhang ZH, Weiss RM, Felder RB. Mitogen-activated protein kinases mediate upregulation of hypothalamic angiotensin II type 1 receptors in heart failure rats. Hypertension 52: 679-686, 2008.
29. Xue B, Beltz TG, Yu Y, Guo F, Gomez-Sanchez CE, Hay M, Johnson AK. Central interactions of aldosterone and angiotensin II in aldosterone-and angiotensin II-induced hypertension. Am J Physiol Heart Circ Physiol 300: H555-H564, 2011.
30. Yamada M, Kushibiki M, Osanai T, Tomita H, Okumura K. Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT1) receptor: possible role of AT1 receptor dimerization. Cardiovasc Res 79: 169-178, 2008.
31. Yu Y, Kang YM, Zhang ZH, Wei SG, Chu Y, Weiss RM, Felder RB. Increased cyclooxygenase-2 expression in hypothalamic paraventricular nucleus in rats with heart failure: role of nuclear factor kappaB. Hypertension 49: 511-518, 2007.
32. Yu Y, Wei SG, Zhang ZH, Gomez-Sanchez E, Weiss RM, Felder RB. Does aldosterone upregulate the brain renin-angiotensin system in rats with heart failure? Hypertension 51: 727-733, 2008.
33. Yu Y, Zhang ZH, Wei SG, Chu Y, Weiss RM, Heistad DD, Felder RB. Central gene transfer of interleukin-10 reduces hypothalamic inflammation and evidence of heart failure in rats after myocardial infarction. Circ Res 101: 304-312, 2007.
34. Yu Y, Zhang ZH, Wei SG, Serrats J, Weiss RM, Felder RB. Brain perivascular macrophages and the sympathetic response to inflammation in rats after myocardial infarction. Hypertension 55: 652-659, 2010.
35. Zhang ZH, Kang YM, Yu Y, Wei SG, Schmidt TJ, Johnson AK, Felder RB. 11beta-hydroxysteroid dehydrogenase type 2 activity in hypothalamic paraventricular nucleus modulates sympathetic excitation. Hypertension 48: 127-133, 2006.
36. Zhang ZH, Wei SG, Francis J, Felder RB. Cardiovascular and renal sympathetic activation by blood-borne TNF-a in rat: the role of central prostaglandins. Am J Physiol Regul Integr Comp Physiol 284: R916-R927, 2003.
37. Zhang ZH, Yu Y, Kang YM, Wei SG, Felder RB. Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats. Am J Physiol Heart Circ Physiol 294: H1067-H1074, 2008.
38. Zhang ZH, Yu Y, Wei SG, Felder RB. Centrally administered lipopoly-saccharide elicits sympathetic excitation via NAD(P)H oxidase-dependent mitogen-activated protein kinase signaling. J Hypertens 28: 806-816, 2010.