Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis

FASEB Journal

Volumn 26, Issue 2, 2012, Pages 832-841

  Burgoyne, Joseph R ^a   Haeussler, Dagmar J ^a   Kumar, Vikas ^a   Ji, Yuhan ^a   Pimental, David R ^a   Zee, Rebecca S ^a   Costello, Cathrine E ^a   Lin, Cheng ^a   McComb, Mark E ^a   Cohen, Richard A ^a   Bachschmid, Markus M ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Growth factor signaling; High fat high glucose diet; Oxidative post translational modifications; Reactive nitrogen species; Reactive oxygen species

Indexed keywords

CYSTEINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; PALMITIC ACID; RAS PROTEIN; THIOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MEMBRANE; ENDOTHELIUM CELL; GENE OVEREXPRESSION; GLUCOSE INTAKE; GOLGI COMPLEX; IN VIVO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLIC STRESS; MOUSE; NONHUMAN; ONCOGENE H RAS; OXIDATION; OXIDATION REDUCTION STATE; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CATTLE; CELLS, CULTURED; CYSTEINE; DIET, HIGH-FAT; DIETARY CARBOHYDRATES; ENDOTHELIAL CELLS; GLUCOSE; LIPOYLATION; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUTANT PROTEINS; OXIDATION-REDUCTION; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; SUCROSE; SUPEROXIDE DISMUTASE;

MUS;

EID: 84863075618     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-189415     Document Type: Article

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