Induced pluripotent stem cell-related genes influence biological behavior and 5-fluorouracil sensitivity of colorectal cancer cells

Journal of Zhejiang University: Science B

Volumn 13, Issue 1, 2012, Pages 11-19

  Shi, Zhong ^a,b   Bai, Rui ^a,b   Fu, Zhi Xuan ^a,b   Zhu, Yong Liang ^a   Wang, Rong Fu ^c   Zheng, Shu ^a,b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b China National Ministry of Education   (China)

^c CENTER FOR CELL AND GENE THERAPY   (United States)

Author keywords

5 fluorouracil; Cancer stem cell; Colorectal cancer; Induced pluripotent stem cell; NANOG

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; FLUOROURACIL; KRUPPEL LIKE FACTOR 4; LENTIVIRUS VECTOR; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CANCER CELL; CANCER STEM CELL; CARCINOGENICITY; CELL ASSAY; CELL PROLIFERATION; COLONY FORMATION; COLORECTAL CANCER; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; GENE EXPRESSION; GENE TARGETING; IN VIVO STUDY; MOUSE; NONHUMAN; ONCOGENE C MYC; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL RATE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL PROLIFERATION; COLORECTAL NEOPLASMS; FEMALE; FLUOROURACIL; HOMEODOMAIN PROTEINS; HT29 CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; OCTAMER TRANSCRIPTION FACTOR-3; PILOT PROJECTS; REAL-TIME POLYMERASE CHAIN REACTION; RNA; SOXB1 TRANSCRIPTION FACTORS;

EID: 84863072617     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B1100154     Document Type: Article

References (46)

1. Almstrup, K., Hoei-Hansen, C. E., Wirkner, U., Blake, J., Schwager, C., Ansorge, W., Nielsen, J. E., Skakkebaek, N. E., Rajpert-de Meyts, E., Leffers, H., 2004. Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling. Cancer Res., 64(14):4736-4743. [doi:10.1158/0008-5472. CAN-04-0679] (Pubitemid 38924515)
2. Bae, K. M., Su, Z., Frye, C., McClellan, S., Allan, R. W., Andrejewski, J. T., Kelley, V., Jorgensen, M., Steindler, D. A., Vieweg, J., et al., 2010. Expression of pluripotent stem cell reprogramming factors by prostate tumor initiating cells. J. Urol., 183(5):2045-2053. [doi:10.1016/j. juro.2009.12.092]
3. Ben-Porath, I., Thomson, M. W., Carey, V. J., Ge, R., Bell, G. W., Regev, A., Weinberg, R. A., 2008. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet., 40(5):499-507. [doi:10.1038/ng.127] (Pubitemid 351601215)
4. Bjerkvig, R., Tysnes, B. B., Aboody, K. S., Najbauer, J., Terzis, A. J., 2005. Opinion: the origin of the cancer stem cell: current controversies and new insights. Nat. Rev. Cancer, 5(11):899-904. [doi:10.1038/nrc1740] (Pubitemid 41746034)
5. Cao, L., Zhou, Y., Zhai, B., Liao, J., Xu, W., Zhang, R., Li, J., Zhang, Y., Chen, L., Qian, H., et al., 2011. Sphereforming cell subpopulations with cancer stem cell properties in human hepatoma cell lines. BMC Gastroenterol., 11(1):71. [doi:10.1186/1471-230X-11-71]
6. Carette, J. E., Pruszak, J., Varadarajan, M., Blomen, V. A., Gokhale, S., Camargo, F. D., Wernig, M., Jaenisch, R., Brummelkamp, T. R., 2010. Generation of iPSCs from cultured human malignant cells. Blood, 115(20):4039-4042. [doi:10.1182/blood-2009-07-231845]
7. Dallas, N. A., Xia, L., Fan, F., Gray, M. J., Gaur, P., van Buren, G. II, Samuel, S., Kim, M. P., Lim, S. J., Ellis, L. M., 2009. Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition. Cancer Res., 69(5):1951-1957. [doi:10.1158/0008-5472. CAN-08-2023]
8. Dontu, G., Abdallah, W. M., Foley, J. M., Jackson, K. W., Clarke, M. F., Kawamura, M. J., Wicha, M. S., 2003. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev., 17(10):1253-1270. [doi:10.1101/gad.1061803] (Pubitemid 36583168)
9. Dylla, S. J., Beviglia, L., Park, I. K., Chartier, C., Raval, J., Ngan, L., Pickell, K., Aguilar, J., Lazetic, S., Smith-Berdan, S., et al., 2008. Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One, 3(6): e2428. [doi:10.1371/journal. pone.0002428]
10. Fan, X., Ouyang, N., Teng, H., Yao, H., 2011. Isolation and characterization of spheroid cells from the HT29 colon cancer cell line. Int. J. Colorectal Dis., 26(10):1279-1285. [doi:10.1007/s00384-011-1248-y]
11. Fang, X., Yu, W., Li, L., Shao, J., Zhao, N., Chen, Q., Ye, Z., Lin, S. C., Zheng, S., Lin, B., 2010. ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS, 14(4):369-384. [doi:10.1089/omi.2010.0053]
12. Freyer, J. P., Sutherland, R. M., 1980. Selective dissociation and characterization of cells from different regions of multicell tumor spheroids. Cancer Res., 40(11):3956-3965. (Pubitemid 10030412)
13. Galli, R., Binda, E., Orfanelli, U., Cipelletti, B., Gritti, A., de Vitis, S., Fiocco, R., Foroni, C., Dimeco, F., Vescovi, A., 2004. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res., 64(19):7011-7021. [doi:10.1158/0008-5472. CAN-04-1364] (Pubitemid 39331011)
14. Jeter, C. R., Badeaux, M., Choy, G., Chandra, D., Patrawala, L., Liu, C., Calhoun-Davis, T., Zaehres, H., Daley, G. Q., Tang, D. G., 2009. Functional evidence that the selfrenewal gene NANOG regulates human tumor development. Stem Cells, 27(5):993-1005. [doi:10.1002/stem.29]
15. Kelly, P. N., Dakic, A., Adams, J. M., Nutt, S. L., Strasser, A., 2007. Tumor growth need not be driven by rare cancer stem cells. Science, 317(5836):337. [doi:10.1126/science. 1142596]
16. Korkaya, H., Wicha, M. S., 2010. Cancer stem cells: nature versus nurture. Nat. Cell Biol., 12(5):419-421. [doi:10. 1038/ncb0510-419]
17. Lacerda, L., Pusztai, L., Woodward, W. A., 2010. The role of tumor initiating cells in drug resistance of breast cancer: implications for future therapeutic approaches. Drug Resist. Updat., 13(4-5):99-108. [doi:10.1016/j.drup. 2010. 08.001]
18. Lapidot, T., Sirard, C., Vormoor, J., Murdoch, B., Hoang, T., Caceres-Cortes, J., Minden, M., Paterson, B., Caligiuri, M. A., Dick, J. E., 1994. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature, 367(6464):645-648. [doi:10.1038/367645a0] (Pubitemid 24067706)
19. Li, F., Tiede, B., Massague, J., Kang, Y., 2007. Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res., 17(1):3-14. [doi:10.1038/sj.cr. 7310118] (Pubitemid 46096419)
20. + liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell, 7(6):694-707. [doi:10.1016/j.stem.2010.11.010]
21. Meng, H. M., Zheng, P., Wang, X. Y., Liu, C., Sui, H. M., Wu, S. J., Zhou, J., Ding, Y. Q., Li, J. M., 2010. Overexpression of Nanog predicts tumor progression and poor prognosis in colorectal cancer. Cancer Biol. Ther., 9(4):295-302. [doi:10.4161/cbt.9.4.10666]
22. Miyoshi, N., Ishii, H., Nagai, K., Hoshino, H., Mimori, K., Tanaka, F., Nagano, H., Sekimoto, M., Doki, Y., Mori, M., 2010. Defined factors induce reprogramming of gastrointestinal cancer cells. PNAS, 107(1):40-45. [doi:10. 1073/pnas.0912407107]
23. Morrison, S. J., Kimble, J., 2006. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature, 441(7097):1068-1074. [doi:10.1038/nature04956] (Pubitemid 43990718)
24. Park, I. H., Zhao, R., West, J. A., Yabuuchi, A., Huo, H., Ince, T. A., Lerou, P. H., Lensch, M. W., Daley, G. Q., 2008. Reprogramming of human somatic cells to pluripotency with defined factors. Nature, 451(7175):141-146. [doi:10. 1038/nature06534]
25. Quintana, E., Shackleton, M., Sabel, M. S., Fullen, D. R., Johnson, T. M., Morrison, S. J., 2008. Efficient tumour formation by single human melanoma cells. Nature, 456(7222):593-598. [doi:10.1038/nature07567]
26. Reya, T., Morrison, S. J., Clarke, M. F., Weissman, I. L., 2001. Stem cells, cancer, and cancer stem cells. Nature, 414(6859):105-111. [doi:10.1038/35102167] (Pubitemid 33041634)
27. Robertson, F. M., Ogasawara, M. A., Ye, Z., Chu, K., Pickei, R., Debeb, B. G., Woodward, W. A., Hittelman, W. N., Cristofanilli, M., Barsky, S. H., 2010. Imaging and analysis of 3D tumor spheroids enriched for a cancer stem cell phenotype. J. Biomol. Screen., 15(7):820-829. [doi: 10.1177/1087057110376541]
28. Saigusa, S., Tanaka, K., Toiyama, Y., Yokoe, T., Okugawa, Y., Ioue, Y., Miki, C., Kusunoki, M., 2009. Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. Ann. Surg. Oncol., 16(12):3488-3498. [doi:10.1245/s10434-009-0617-z]
29. Saiki, Y., Ishimaru, S., Mimori, K., Takatsuno, Y., Nagahara, M., Ishii, H., Yamada, K., Mori, M., 2009. Comprehensive analysis of the clinical significance of inducing pluripotent stemness-related gene expression in colorectal cancer cells. Ann. Surg. Oncol., 16(9):2638-2644. [doi:10. 1245/s10434-009-0567-5]
30. Shackleton, M., Quintana, E., Fearon, E. R., Morrison, S. J., 2009. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell, 138(5):822-829. [doi:10.1016/j.cell. 2009.08.017]
31. Sherar, M. D., Noss, M. B., Foster, F. S., 1987. Ultrasound backscatter microscopy images the internal structure of living tumour spheroids. Nature, 330(6147):493-495. [doi:10.1038/330493a0] (Pubitemid 18006432)
32. Singh, A., Settleman, J., 2010. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene, 29(34):4741-4751. [doi:10.1038/onc. 2010.215]
33. Singh, S. K., Hawkins, C., Clarke, I. D., Squire, J. A., Bayani, J., Hide, T., Henkelman, R. M., Cusimano, M. D., Dirks, P. B., 2004. Identification of human brain tumour initiating cells. Nature, 432(7015):396-401. [doi:10.1038/nature03128] (Pubitemid 39551674)
34. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., Yamanaka, S., 2007. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131(5):861-872. [doi:10.1016/j.cell. 2007.11.019] (Pubitemid 350138099)
35. Tang, C., Ang, B. T., Pervaiz, S., 2007. Cancer stem cell: target for anti-cancer therapy. FASEB J., 21(14):3777-3785. [doi:10.1096/fj.07-8560rev] (Pubitemid 350232335)
36. Tindall, M. J., Please, C. P., 2007. Modelling the cell cycle and cell movement in multicellular tumour spheroids. Bull. Math. Biol., 69(4):1147-1165. [doi:10.1007/s11538-006-9110-z] (Pubitemid 46776463)
37. Todaro, M., Alea, M. P., di Stefano, A. B., Cammareri, P., Vermeulen, L., Iovino, F., Tripodo, C., Russo, A., Gulotta, G., Medema, J. P., et al., 2007. Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell, 1(4):389-402. [doi:10. 1016/j.stem.2007.08. 001] (Pubitemid 47506537)
38. Waleh, N. S., Brody, M. D., Knapp, M. A., Mendonca, H. L., Lord, E. M., Koch, C. J., Laderoute, K. R., Sutherland, R. M., 1995. Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker. Cancer Res., 55(24):6222-6226.
39. Wang, X., Kruithof-de Julio, M., Economides, K. D., Walker, D., Yu, H., Halili, M. V., Hu, Y. P., Price, S. M., Abate-Shen, C., Shen, M. M., 2009. A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature, 461(7263):495-500. [doi:10.1038/nature08361]
40. Wei, D., Kanai, M., Huang, S., Xie, K., 2006. Emerging role of KLF4 in human gastrointestinal cancer. Carcinogenesis, 27(1):23-31. [doi:10.1093/carcin/ bgi243] (Pubitemid 43032979)
41. Wibe, E., 1980. Resistance to vincristine of human cells grown as multicellular spheroids. Br. J. Cancer, 42(6):937-941. [doi:10.1038/bjc.1980. 344] (Pubitemid 11199296)
42. Yeung, T. M., Gandhi, S. C., Wilding, J. L., Muschel, R., Bodmer, W. F., 2010. Cancer stem cells from colorectal cancer-derived cell lines. PNAS, 107(8):3722-3727. [doi:10.1073/pnas.0915135107]
43. Yin, B. B., Wu, S. J., Zong, H. J., Ma, B. J., Cai, D., 2011. Preliminary screening and identification of stem cell-like sphere clones in a gallbladder cancer cell line GBC-SD. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 12(4):256-263. [doi:10.1631/jzus. B1000303]
44. Yori, J. L., Johnson, E., Zhou, G., Jain, M. K., Keri, R. A., 2010. Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression. J. Biol. Chem., 285(22):16854-16863. [doi:10.1074/jbc. M110.114546]
45. Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al., 2007. Induced pluripotent stem cell lines derived from human somatic cells. Science, 318(5858):1917-1920. [doi:10.1126/science.1151526]
46. Zhao, W., Hisamuddin, I. M., Nandan, M. O., Babbin, B. A., Lamb, N. E., Yang, V. W., 2004. Identification of Kruppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. Oncogene, 23(2):395-402. [doi:10. 1038/sj.onc.1207067] (Pubitemid 38174993)