A novel cardioprotective agent in cardiac transplantation: Metformin activation of AMP-activated protein kinase decreases acute ischemia-reperfusion injury and chronic rejection

Yale Journal of Biology and Medicine

Volumn 84, Issue 4, 2011, Pages 423-432

  Chin, Jocelyn T ^a   Troke, Joshua J ^a   Kimura, Naoyuki ^a   Itoh, Satoshi ^a   Wang, Xi ^a   Palmer, Owen P ^a   Robbins, Robert C ^a   Fischbein, Michael P ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute rejection; AMPK; Apoptosis; Cardiac transplantation; Chronic rejection; I R injury; Metformin

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIAC ALLOGRAFT VASCULOPATHY; CARDIAC GRAFT REJECTION; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART TRANSPLANTATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; POSTOPERATIVE PERIOD; REPERFUSION INJURY;

AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; CARDIOTONIC AGENTS; ENDOTHELIAL CELLS; ENZYME ACTIVATION; GRAFT REJECTION; HEART TRANSPLANTATION; METFORMIN; MICE; MICE, INBRED C57BL; REPERFUSION INJURY; RIBONUCLEOTIDES; SIGNAL TRANSDUCTION; TRANSPLANTATION, HOMOLOGOUS;

CHICKEN ANEMIA VIRUS; MURINAE;

EID: 84863046265     PISSN: 00440086     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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