Simple method for the routine determination of betaine and N,N- dimethylglycine in blood and urine

Clinical Chemistry

Volumn 44, Issue 9, 1998, Pages 1937-1941

  Laryea, Maurice D ^a   Steinhagen, Folkert ^a   Pawliczek, Sandra ^a   Wendel, Udo ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE; DIMETHYLGLYCINE;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DRUG BLOOD LEVEL; DRUG URINE LEVEL; HOMOCYSTINURIA; HUMAN;

EID: 0031721546     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/44.9.1937     Document Type: Article

References (15)

1. Wilcken DE, Dudman NP, Tyrrell PA. Homocystinuria due to cystathionine beta-synthase deficiency-the effects of betaine treatment in pyridoxine-responsive patients. Metabolism 1985; 34:1115-21.
2. Wendel U, Bremer HJ. Betaine in the treatment of homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency. Eur J Pediatr 1984;142:147-50.
3. Holme E, Kjellman B, Ronge E. Betaine for treatment of homocystinuria caused by methylenetetrahydrofolate reductase deficiency. Arch Dis Child 1989;64:1061-4.
4. Smolin LA, Benevenga NJ, Berlow S. The use of betaine for the treatment of homocystinuria. J Pediatr 1981;99:467-72.
5. Surtees R, Leonard J, Austin S. Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway. Lancet 1991;338:1550-4.
6. Gorham J. Quantitative analysis of quaternary ammonium compounds by ion exchange and ion pair high performance liquid chromatography. In: Williams PA, Hudson MJ, eds. Recent developments in ion exchange, London: Elsevier Applied Science, 1987:79-86.
7. Laryea MD, Zass R, Ritgen J, Wendel U. Simultaneous determination of betaine and N,N-dimethylglycine in urine. Clin Chim Acta 1994;230:169-75.
8. 1H-NMR spectroscopy of blood plasma for metabolic studies. Clin Chem 1994;40:1245-50.
9. Davies SE, Chalmers RA, Randall EW, Iles RA. Betaine metabolism in human neonates and developing rats. Clin Chim Acta 1988;178:241-9.
10. Dudman NP, Wilcken DE, Wang J, Lynch JF, Macey D, Lundberg P. Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy, and enzymology. Arterioscler Thromb 1993;13:1253-60.
11. Allen RH, Stabler SP, Lindenbaum J. Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism. Metabolism 1993;42:1448-60.
12. Koch DO, Peters T Jr. Selection and evaluation of methods. In: Kaplan L, Pesce A, eds. Tietz textbook of clinical chemistry. 2nd ed. Philadelphia: WB Saunders, 1994:508-25.
13. Durst HD, Milano M, Kitka EJ, Connely SA, Grushka E. Phenacyl esters of fatty acids via crown ether catalysts for enhanced ultraviolet detection in liquid chromatography. Anal Chem 1975; 47:1797-801.
14. van Kempen TA, Odle J. Quantification of carnitine esters by high-performance liquid chromatography. Effect of feeding medium-chain triglycerides on the plasma carnitine ester profile. J Chromatogr 1992;584:157-65.
15. Gorham J, Mcdonnell E, Wyn Jones RG. Determination of betaines as ultraviolet-absorbing esters. Anal Chim Acta 1982;138: 277-83.