Insufficient DNA methylation affects healthy aging and promotes age-related health problems

Clinical Epigenetics

Volumn 2, Issue 2, 2011, Pages 349-360

  Liu, Liang ^a   Van Groen, Thomas ^b   Kadish, Inga ^b   Li, Yuanyuan ^a   Wang, Deli ^c   James, Smitha R ^d   Karpf, Adam R ^d   Tollefsbol, Trygve O ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Cognition; DNA methylation; Dnmt1; Epigenetics; Healthy aging

Indexed keywords

DNA METHYLTRANSFERASE 1; GENOMIC DNA;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY FAT; BODY WEIGHT; BONE DENSITY; CONTROLLED STUDY; DNA METHYLATION; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME ACTIVITY; EPIGENETICS; FAT CONTENT; GENETIC ASSOCIATION; HAPLOINSUFFICIENCY; HEALTH STATUS; LEARNING DISORDER; MALE; MAZE TEST; MEMORY DISORDER; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MORTALITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TASK PERFORMANCE;

EID: 84863012853     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1007/s13148-011-0042-6     Document Type: Article

References (46)

1. Banu J, Wang L, Kalu DN (2002) Age-related changes in bone mineral content and density in intact male F344 rats. Bone 30:125-130 (Pubitemid 34044309)
2. Barnes CA (1979) Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. J Comp Physiol Psychol 93:74-104 (Pubitemid 9140564)
3. Bjornsson HT, Fallin MD, Feinberg AP (2004) An integrated epigenetic and genetic approach to common human disease. Trends Genet 20:350-358 (Pubitemid 38943025)
4. Bollati V, Schwartz J, Wright R, Litonjua A, Tarantini L, Suh H, Sparrow D, Vokonas P, Baccarelli A (2009) Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev 130:234-239
5. Brooks PJ, Marietta C, Goldman D (1996) DNA mismatch repair and DNA methylation in adult brain neurons. J Neurosci 16:939-945 (Pubitemid 26140849)
6. Casillas MA Jr, Lopatina N, Andrews LG, Tollefsbol TO (2003) Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts. Mol Cell Biochem 252:33-43 (Pubitemid 37220730)
7. Fan G, Beard C, Chen RZ, Csankovszki G, Sun Y, Siniaia M, Biniszkiewicz D, Bates B, Lee PP, Kuhn R et al (2001) DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J Neurosci 21:788-797 (Pubitemid 32163120)
8. Feng J, Fouse S, Fan G (2007) Epigenetic regulation of neural gene expression and neuronal function. Pediatr Res 61:58R-63R (Pubitemid 46653070)
9. Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G (2010) Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci 13:423-430
10. Fraga MF, Esteller M (2007) Epigenetics and aging: the targets and the marks. Trends Genet 23:413-418 (Pubitemid 47088010)
11. Gallagher M, Rapp PR (1997) The use of animal models to study the effects of aging on cognition. Annu Rev Psychol 48:339-370 (Pubitemid 127485180)
12. Gaudet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, Gray JW, Leonhardt H, Jaenisch R (2003) Induction of tumors in mice by genomic hypomethylation. Science 300:489-492 (Pubitemid 36444330)
13. Gluckman PD, Hanson MA, Buklijas T, Low FM, Beedle AS (2009) Epigenetic mechanisms that underpin metabolic and cardiovascular diseases. Nat Rev Endocrinol 5:401-408
14. Goto K, Numata M, Komura JI, Ono T, Bestor TH, Kondo H (1994) Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice. Differentiation 56:39-44 (Pubitemid 24102005)
15. Grady CL, Craik FI (2000) Changes in memory processing with age. Curr Opin Neurobiol 10:224-231 (Pubitemid 30201116)
16. Holliday R (1999) Is there an epigenetic component in long-term memory? J Theor Biol 200:339-341 (Pubitemid 29504869)
17. Huffman DM, Johnson MS, Watts A, Elgavish A, Eltoum IA, Nagy TR (2007) Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake. Cancer Res 67:417-424 (Pubitemid 46142801)
18. Inano K, Suetake I, Ueda T, Miyake Y, Nakamura M, Okada M, Tajima S (2000) Maintenance-type DNA methyltransferase is highly expressed in post-mitotic neurons and localized in the cytoplasmic compartment. J Biochem 128:315-321
19. Li E, Bestor TH, Jaenisch R (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69:915-926
20. Liu L, Ikonen S, Heikkinen T, Heikkila M, Puolivali J, van Groen T, Tanila H (2002) Effects of fimbria-fornix lesion and amyloid pathology on spatial learning and memory in transgenic APP+ PS1 mice. Behav Brain Res 134:433-445 (Pubitemid 34912723)
21. Liu R, Liu IY, Bi X, Thompson RF, Doctrow SR, Malfroy B, Baudry M (2003) Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics. Proc Natl Acad Sci USA 100:8526-8531 (Pubitemid 36842578)
22. Liu L, Berletch JB, Green JG, Pate MS, Andrews LG, Tollefsbol TO (2004) Telomerase inhibition by retinoids precedes cytodifferentiation of leukemia cells and may contribute to terminal differentiation. Mol Cancer Ther 3:1003-1009 (Pubitemid 39199595)
23. Liu L, van Groen T, Kadish I, Tollefsbol TO (2009) DNA methylation impacts on learning and memory in aging. Neurobiol Aging 30:549-560
24. Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD, Rogers J (2010) Epigenetic changes in Alzheimer's disease: decrements in DNA methylation. Neurobiol Aging 31:2025-2037
25. Mays-Hoopes L, Chao W, Butcher HC, Huang RC (1986) Decreased methylation of the major mouse long interspersed repeated DNA during aging and in myeloma cells. Dev Genet 7:65-73 (Pubitemid 16026690)
26. Nagy TR, Clair AL (2000) Precision and accuracy of dual-energy Xray absorptiometry for determining in vivo body composition of mice. Obes Res 8:392-398
27. Okano M, Bell DW, Haber DA, Li E (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99:247-257 (Pubitemid 29519904)
28. Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa RC, Cota P, Wittnam JL, Gogol-Doering A, Opitz L et al (2010) Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 328:753-756
29. Rando TA (2010) Epigenetics and aging. Exp Gerontol 45:253-254
30. Rath PC, Kanungo MS (1989) Methylation of repetitive DNA sequences in the brain during aging of the rat. FEBS Lett 244:193-198 (Pubitemid 19050509)
31. Ray D, Wu A, Wilkinson JE, Murphy HS, Lu Q, Kluve-Beckerman B, Liepnieks JJ, Benson M, Yung R, Richardson B (2006) Aging in heterozygous Dnmt1-deficient mice: effects on survival, the DNA methylation genes, and the development of amyloidosis. J Gerontol A Biol Sci Med Sci 61:115-124 (Pubitemid 43334607)
32. Reul JM, Hesketh SA, Collins A, Mecinas MG (2009) Epigenetic mechanisms in the dentate gyrus act as a molecular switch in hippocampus-associated memory formation. Epigenetics 4:434-439
33. Robertson KD (2005) DNA methylation and human disease. Nat Rev Genet 6:597-610 (Pubitemid 41044297)
34. Santos F, Hendrich B, Reik W, Dean W (2002) Dynamic reprogramming of DNA methylation in the early mouse embryo. Dev Biol 241:172-182 (Pubitemid 34066770)
35. Schlessinger D, Van Zant G (2001) Does functional depletion of stem cells drive aging? Mech Ageing Dev 122:1537-1553 (Pubitemid 32757131)
36. Shukitt-Hale B, McEwen JJ, Szprengiel A, Joseph JA (2004) Effect of age on the radial arm water maze-a test of spatial learning and memory. Neurobiol Aging 25:223-229 (Pubitemid 38121695)
37. Siegmund KD, Connor CM, Campan M, Long TI, Weisenberger DJ, Biniszkiewicz D, Jaenisch R, Laird PW, Akbarian S (2007) DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One 2:e895
38. Silva PN, Gigek CO, Leal MF, Bertolucci PH, de Labio RW, Payao SL, Smith Mde A (2008) Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease. J Alzheimers Dis 13:173-176 (Pubitemid 352038520)
39. SinclairKD, Allegrucci C, Singh R, Gardner DS, Sebastian S, BisphamJ, Thurston A, Huntley JF, Rees WD, Maloney CA et al (2007) DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci USA 104:19351-19356
40. Song L, James SR, Kazim L, Karpf AR (2005) Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry. Anal Chem 77:504-510 (Pubitemid 40116829)
41. Stenvinkel P, Karimi M, Johansson S, Axelsson J, Suliman M, Lindholm B, Heimburger O, Barany P, Alvestrand A, Nordfors L et al (2007) Impact of inflammation on epigenetic DNA methylation-a novel risk factor for cardiovascular disease? J Intern Med 261:488-499 (Pubitemid 46587721)
42. van Groen T, Kadish I, Wyss JM (2002) Old rats remember old tricks; memories of the water maze persist for 12 months. Behav Brain Res 136:247-255 (Pubitemid 35246410)
43. Wang SC, Oelze B, Schumacher A (2008) Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS One 3: e2698
44. Wilson VL, Jones PA (1983) DNA methylation decreases in aging but not in immortal cells. Science 220:1055-1057 (Pubitemid 13090144)
45. Yung R, Ray D, Eisenbraun JK, Deng C, Attwood J, Eisenbraun MD, Johnson K, Miller RA, Hanash S, Richardson B (2001) Unexpected effects of a heterozygous dnmt1 null mutation on age-dependent DNA hypomethylation and autoimmunity. J Gerontol A Biol Sci Med Sci 56:B268-B276 (Pubitemid 32522248)
46. Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, Lein ES, Eadie BD, Willhoite AR, Muotri AR et al (2003) Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci USA 100:6777-6782 (Pubitemid 36666656)