Unexpected effects of a heterozygous Dnmt1 null mutation on age-dependent DNA hypomethylation and autoimmunity

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 56, Issue 6, 2001, Pages B268-B276

  Yung, R ^a   Ray, D ^a   Eisenbraun, J K ^a   Deng, C ^a   Attwood, J ^a   Eisenbraun, M D ^a   Johnson, K ^a   Miller, R A ^a   Hanash, S ^a   Richardson, B ^a  

^a 5310 Can Ctr/Geriatrics Ctr Bldg   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CELL DNA; METHYLCYTOSINE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CELL AGING; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; GENE MUTATION; LIVER; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALIVARY GLAND; T LYMPHOCYTE;

AGING; ANIMALS; AUTOIMMUNITY; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DNA-BINDING PROTEINS; FEMALE; HETEROZYGOTE; METHYL-CPG-BINDING PROTEIN 2; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; REFERENCE VALUES; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0034989233     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/56.6.B268     Document Type: Article

References (36)

1. Methylation-induced repression - Belts, braces, and chromatin
2. DNA methylation and embryogenesis
3. DNA methylation: Regulation of gene expression and role in the immune system
4. Formation of methylation patterns in the mammalian genome
5. Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to induce a lupus-like disease in syngeneic mice
6. Mechanisms of drug induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo
7. Quantitative changes in T cell DNA methylation occur during differentiation and ageing
8. Genomic 5-methyldeoxycytidine decreases with age
9. The 5-methylcytosine in DNA of rats
10. Spontaneous development of organ-specific autoimmune lesions in aged C57BL/6 mice
11. Similarities in B cell repertoire development between autoimmune and aging normal mice
12. Immune system
13. Targeted mutation of the DNA methyl-transferase gene results in embryonic lethality
14. Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells
15. Prognostic factors in lupus nephritis: Contribution of renal histologic data
16. Patterns of cytokine gene expression by CD4+ T cells from young and old mice
17. Mechanisms of drug-induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo
18. Role of the ras-MAPK signaling pathway in the DNA methyltransferase response to DNA hypomethylation
19. Asymptotic optimality of Fisher's method of combining independent tests
20. Biological significance of DNA methylation in the ageing process
21. Endogenous virus genomes become hypomethylated tissue - Specifically during aging process of C57BL mice
22. Suppression of intestinal neoplasia by DNA hypomethylation
23. DNA methylation and chromatin modification
24. Number of CpG islands and genes in human and mouse
25. Effect of mitogenic stimulation and DNA methylation on human T-cell DNA methyltransferase expression and activity
26. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
27. A mammalian protein with specific demethylase activity for mCpG DNA
28. DNA methylation is a reversible biological signal
29. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
30. DNA demethylation in vitro: Involvement of RNA
31. MeCP2 driven transcriptional repression in vitro: Selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery
32. Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2
33. DNA hypomethylation leads to elevated mutation rates
34. Analysis of human peripheral blood T cells and single-cell derived T cell clones uncovers extensive clonal CpG island methylation heterogeneity throughout the genome
35. Aging and immunity to tuberculosis: Increased susceptibility of old mice reflects a decreased capacity to generate mediator T lymphocytes
36. Spontaneous occurrence of autoimmune cholangitis in senescent mice