Stem cell therapy for erectile dysfunction: A critical review

Stem Cells and Development

Volumn 21, Issue 3, 2012, Pages 343-351

  Lin, Ching Shwun ^a   Xin, Zhong Cheng ^b   Wang, Zhong ^c   Deng, Chunhua ^d   Huang, Yun Ching ^e   Lin, Guiting ^a   Lue, Tom F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PEKING UNIVERSITY FIRST HOSPITAL   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

^d SUN YAT SEN UNIVERSITY   (China)

^e CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; BETA GALACTOSIDASE; BROXURIDINE; CD31 ANTIGEN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCOSYLATED HEMOGLOBIN; GREEN FLUORESCENT PROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE V INHIBITOR; STREPTOZOCIN; VON WILLEBRAND FACTOR;

ADIPOSE DERIVED STEM CELL; CAVERNOUS SINUS; CELL LABELING; ENDOTHELIUM CELL; ERECTILE DYSFUNCTION; FAT INTAKE; GLUCOSE BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; NERVE INJURY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROSTATECTOMY; QUALITY OF LIFE; REVIEW; SEXUAL BEHAVIOR; SKELETAL MUSCLE; SMOOTH MUSCLE FIBER; STEM CELL TRANSPLANTATION; TUNICA ALBUGINEA; UMBILICAL CORD;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CLINICAL TRIALS AS TOPIC; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; ERECTILE DYSFUNCTION; FLUORESCENT DYES; GREEN FLUORESCENT PROTEINS; HUMANS; MALE; PENIS; RATS; STAINING AND LABELING; STEM CELL TRANSPLANTATION; STEM CELLS;

RATTUS;

EID: 84863012120     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2011.0303     Document Type: Review

References (46)

1. Litwin MS, RJ Nied and N Dhanani. (1998). Health-related quality of life in men with erectile dysfunction. J Gen Intern Med 13:159-166. (Pubitemid 28128994)
2. Nehra A. (2007). Oral and non-oral combination therapy for erectile dysfunction. Rev Urol 9:99-105.
3. Dorsey P, C Keel, M Klavens and WJ Hellstrom. (2010). Phosphodiesterase type 5 (PDE5) inhibitors for the treatment of erectile dysfunction. Expert Opin Pharmacother 11:1109-1122.
4. Lue TF. (2000). Erectile dysfunction. N Engl J Med 342: 1802-1813. (Pubitemid 30390241)
5. Mulhall JP, AJ Bella, A Briganti, A McCullough and G Brock. (2010). Erectile function rehabilitation in the radical prostatectomy patient. J Sex Med 7:1687-1698.
6. Iacono F, R Giannella, P Somma, G Manno, F Fusco and V Mirone. (2005). Histological alterations in cavernous tissue after radical prostatectomy. J Urol 173:1673-1676. (Pubitemid 40524802)
7. Gratzke C, J Angulo, K Chitaley, YT Dai, NN Kim, JS Paick, U Simonsen, S Uckert, E Wespes, et al. (2010). Anatomy, physiology, and pathophysiology of erectile dysfunction. J Sex Med 7:445-475.
8. Albersen M, G Lin, TM Fandel, H Zhang, X Qiu, CS Lin and TF Lue. (2011). Functional, metabolic, and morphologic characteristics of a novel rat model of type 2 diabetesassociated erectile dysfunction. Urology 78:e1-e8.
9. Lin G, X Qiu, TM Fandel, M Albersen, Z Wang, TF Lue and CS Lin. (2011). Improved penile histology by phalloidin stain circular and longitudinal cavernous smooth muscles, dual-endothelium arteries, and erectile dysfunction-associated changes Urology [Epub ahead of print]; DOI: 10.1016/j.urology.2011.06.021.
10. Qiu X, TM Fandel, G Lin, YC Huang, YT Dai, TF Lue and CS Lin. (2011). Cavernous smooth muscle hyperplasia in a rat model of hyperlipidemia-associated erectile dysfunction. BJU Int [Epub ahead of print]; DOI 101111/j.1464-410X. 2011.10162.x.
11. Lin CS, ZC Xin, CH Deng, H Ning, G Lin and TF Lue. (2008). Recent advances in andrology-related stem cell research. Asian J Androl 10:171-175. (Pubitemid 351337976)
12. Lin CS. (2010). Advances in stem cell therapy for the lower urinary tract. World J Stem Cells 2:1-4.
13. Bochinski D, GT Lin, L Nunes, R Carrion, N Rahman, CS Lin and TF Lue. (2004). The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury. BJU Int 94:904-909. (Pubitemid 39472495)
14. Kim Y, F de Miguel, I Usiene, D Kwon, N Yoshimura, J Huard and MB Chancellor. (2006). Injection of skeletal muscle-derived cells into the penis improves erectile function. Int J Impot Res 18:329-334.
15. Deng W, TJ Bivalacqua, NN Chattergoon, AL Hyman, JR Jeter, Jr. and PJ Kadowitz. (2003). Adenoviral gene transfer of eNOS: high-level expression in ex vivo expanded marrow stromal cells. Am J Physiol Cell Physiol 285:C1322-C1329. (Pubitemid 37296309)
16. Bivalacqua TJ, W Deng, M Kendirci, MF Usta, C Robinson, BK Taylor, SN Murthy, HC Champion, WJ Hellstrom and PJ Kadowitz. (2007). Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction. Am J Physiol Heart Circ Physiol 292:H1278-H1290. (Pubitemid 46377115)
17. Song YS, HJ Lee, IH Park, WK Kim, JH Ku and SU Kim. (2007). Potential differentiation of human mesenchymal stem cell transplanted in rat corpus cavernosum toward endothelial or smooth muscle cells. Int J Impot Res 19:378-385. (Pubitemid 47026078)
18. Song YS, HJ Lee, IH Park, IS Lim, JH Ku and SU Kim. (2008). Human neural crest stem cells transplanted in rat penile corpus cavernosum to repair erectile dysfunction. BJU Int 102:220-224; discussion 224. (Pubitemid 351852582)
19. Nolazco G, I Kovanecz, D Vernet, RA Gelfand, J Tsao, MG Ferrini, T Magee, J Rajfer and NF Gonzalez-Cadavid. (2008). Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat. BJU Int 101:1156-1164. (Pubitemid 351502662)
20. Fall PA, M Izikki, L Tu, S Swieb, F Giuliano, J Bernabe, R Souktani, C Abbou, S Adnot, S Eddahibi and R Yiou. (2009). Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction. Eur Urol 56:716-725.
21. Song Y, N Mehta, B Sheh, F Saljooque, HS U and M Rajasekaran. (2009). Transdifferentiation of rat fetal brain stem cells into penile smooth muscle cells. BJU Int 104:257-262.
22. Garcia MM, TM Fandel, G Lin, AW Shindel, L Banie, CS Lin and TF Lue. (2010). Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cells. J Sex Med 7:89-98.
23. Huang YC, H Ning, AW Shindel, TM Fandel, G Lin, AM Harraz, TF Lue and CS Lin. (2010). The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat model. J Sex Med 7:1391-1400.
24. Abdel Aziz MT, S El-Haggar, T Mostafa, H Atta, H Fouad, S Mahfouz, L Rashed, D Sabry, A Senbel and GA Ali. (2010). Effect of mesenchymal stem cell penile transplantation on erectile signaling of aged rats. Andrologia 42:187-192.
25. Bahk JY, JH Jung, H Han, SK Min and YS Lee. (2010). Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplant: preliminary report of 7 cases. Exp Clin Transplant 8:150-160.
26. Albersen M, TM Fandel, G Lin, G Wang, L Banie, CS Lin and TF Lue. (2010). Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med 7:3331-3340.
27. Kendirci M, L Trost, B Bakondi, MJ Whitney, WJ Hellstrom and JL Spees. (2010). Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. J Urol 184:1560-1566.
28. Qiu X, H Lin, Y Wang, W Yu, Y Chen, R Wang and Y Dai. (2011). Intracavernous transplantation of bone marrowderived mesenchymal stem cells restores erectile function of streptozocin-induced diabetic rats. J Sex Med 8:427-436.
29. Qiu X, C Sun, W Yu, H Lin, Z Sun, Y Chen, R Wang and Y Dai. (2011). Combined strategy of mesenchymal stem cells injection with VEGF gene therapy for the treatment of diabetes associated erectile dysfunction. J Androl [Epub ahead of print]; DOI 102164/jandrol.110.012666.
30. Gou X, WY He, MZ Xiao, M Qiu, M Wang, YZ Deng, CD Liu, ZB Tang, J Li and Y Chen. (2011). Transplantation of endothelial progenitor cells transfected with VEGF165 to restore erectile function in diabetic rats. Asian J Androl 13:332-338.
31. Lin G, M Albersen, AM Harraz, TM Fandel, M Garcia, MH McGrath, BR Konety, TF Lue and CS Lin. (2011). Cavernous nerve repair with allogenic adipose matrix and autologous adipose-derived stem cells. Urology 77:1509.e1-1509.e8.
32. Lin G, X Qiu, TM Fandel, L Banie, G Wang, TF Lue and CS Lin. (2011). Tracking intracavernously injected adiposederived stem cells to bone marrow. Int J Impot Res [Epub ahead of print]; DOI 101038/ijir.2011.38.
33. Fandel TM, M Albersen, X Qiu, G Lin, TF Lue and CS Lin. (2011). Recruitment of intracavernously injected adiposederived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous-nerve injury. Eur Urol [Epub ahead of print]. PubMed. DOI 101016/ j.eururo.2011.07. 061.
34. Weiss DJ, D Liggitt and JG Clark. (1999). Histochemical discrimination of endogenous mammalian beta-galactosidase activity from that resulting from lac-Z gene expression. Histochem J 31:231-236. (Pubitemid 29320385)
35. Billinton N and AW Knight. (2001). Seeing the wood through the trees: a review of techniques for distinguishing green fluorescent protein from endogenous autofluorescence. Anal Biochem 291:175-197. (Pubitemid 32373153)
36. Castanheira P, LT Torquetti, DR Magalhas, MB Nehemy and AM Goes. (2009). DAPI diffusion after intravitreal injection of mesenchymal stem cells in the injured retina of rats. Cell Transplant 18:423-431.
37. Brulport M, W Schormann, A Bauer, M Hermes, C Elsner, FJ Hammersen, W Beerheide, D Spitkovsky, W Hartig, et al. (2007). Fate of extrahepatic human stem and precursor cells after transplantation into mouse livers. Hepatology 46:861-870. (Pubitemid 47436132)
38. Kruyt MC, J De Bruijn, M Veenhof, FC Oner, CA Van Blitterswijk, AJ Verbout and WJ Dhert. (2003). Application and limitations of chloromethyl-benzamidodialkylcarbocyanine for tracing cells used in bone tissue engineering. Tissue Eng 9:105-115. (Pubitemid 36228182)
39. Li N, H Yang, L Lu, C Duan, C Zhao and H Zhao. (2008). Comparison of the labeling efficiency of BrdU, DiI and FISH labeling techniques in bone marrow stromal cells. Brain Res 1215:11-19.
40. Onifer SM, LA White, SR Whittemore and VR Holets. (1993). In vitro labeling strategies for identifying primary neural tissue and a neuronal cell line after transplantation in the CNS. Cell Transplant 2:131-149. (Pubitemid 23134490)
41. Schormann W, FJ Hammersen, M Brulport, M Hermes, A Bauer, C Rudolph, M Schug, T Lehmann, A Nussler, et al. (2008). Tracking of human cells in mice. Histochem Cell Biol 130:329-338.
42. Salic A and TJ Mitchison. (2008). A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci U S A 105:2415-2420. (Pubitemid 351520528)
43. Rakic P. (2002). Neurogenesis in adult primate neocortex: an evaluation of the evidence. Nat Rev Neurosci 3:65-71. (Pubitemid 135706566)
44. Fandel TM, AJ Bella, G Lin, K Tantiwongse, CS Lin, J Pohl and TF Lue. (2008). Intracavernous growth differentiation factor-5 therapy enhances the recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med 5:1866-1875.
45. Bochinski D, PS Hsieh, L Nunes, GT Lin, CS Lin, EM Spencer and TF Lue. (2004). Effect of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 complex in cavernous nerve cryoablation. Int J Impot Res 16:418-423. (Pubitemid 39319041)
46. Hsieh PS, DJ Bochinski, GT Lin, L Nunes, CS Lin and TF Lue. (2003). The effect of vascular endothelial growth factor and brain-derived neurotrophic factor on cavernosal nerve regeneration in a nerve-crush rat model. BJU Int 92:470-475. (Pubitemid 37100532)