Recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury

European Urology

Volumn 61, Issue 1, 2012, Pages 201-210

  Fandel, Thomas M ^a   Albersen, Maarten ^a,b   Lin, Guiting ^a   Qiu, Xuefeng ^a,c   Ning, Hongxiu ^a   Banie, Lia ^a   Lue, Tom F ^a   Lin, Ching Shwun ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c NANJING UNIVERSITY   (China)

Author keywords

Adipose derived stem cells; Cavernous nerve injury; Chemokines; Erectile dysfunction; Major pelvic ganglion; Nerve regeneration; nNOS; Radical prostatectomy nerve sparing; S 100; SDF 1

Indexed keywords

COLLAGEN; STROMAL CELL DERIVED FACTOR 1;

ADIPOSE DERIVED STEM CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAVERNOUS NERVE INJURY; CONTROLLED STUDY; CORPUS CAVERNOSUM; CRUSH TRAUMA; ERECTILE DYSFUNCTION; GANGLION; MALE; NERVE INJURY; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE; THERAPY EFFECT; TREATMENT OUTCOME; UPREGULATION;

ADIPOSE TISSUE; ANIMALS; CHEMOKINE CXCL12; COLLAGEN; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; ERECTILE DYSFUNCTION; GANGLIA; HYPOGASTRIC PLEXUS; IMMUNOHISTOCHEMISTRY; MALE; MYOCYTES, SMOOTH MUSCLE; NERVE REGENERATION; NITRIC OXIDE SYNTHASE TYPE III; PENILE ERECTION; PENIS; PROSTATECTOMY; PUDENDAL NERVE; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; STEM CELL TRANSPLANTATION; TIME FACTORS;

EID: 82255191778     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2011.07.061     Document Type: Article

References (24)

1. A. Heidenreich, J. Bellmunt, and M. Bolla EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and treatment of clinically localised disease Eur Urol 59 2011 61 71
2. Y.D. Dubbelman, G.R. Dohle, and F.H. Schröder Sexual function before and after radical retropubic prostatectomy: a systematic review of prognostic indicators for a successful outcome Eur Urol 50 2006 711 720 (Pubitemid 44332681)
3. F. Montorsi, G. Brock, and J. Lee Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nerve-sparing radical prostatectomy Eur Urol 54 2008 924 931
4. K. Hatzimouratidis, A.L. Burnett, D. Hatzichristou, A.R. McCullough, F. Montorsi, and J.P. Mulhall Phosphodiesterase type 5 inhibitors in postprostatectomy erectile dysfunction: a critical analysis of the basic science rationale and clinical application Eur Urol 55 2009 334 347
5. D. Bochinski, G.T. Lin, and L. Nunes The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury BJU Int 94 2004 904 909 (Pubitemid 39472495)
6. P.A. Fall, M. Izikki, and L. Tu Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction Eur Urol 56 2009 716 726
7. M. Kendirci, L. Trost, B. Bakondi, M.J. Whitney, W.J. Hellstrom, and J.L. Spees Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury J Urol 184 2010 1560 1566
8. G. Lin, M. Garcia, and H. Ning Defining stem and progenitor cells within adipose tissue Stem Cells Dev 17 2008 1053 1063
9. P.A. Zuk The adipose-derived stem cell: looking back and looking ahead Mol Biol Cell 21 2010 1783 1787
10. M. Albersen, T.M. Fandel, and G. Lin Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury J Sex Med 7 2010 3331 3340
11. L. Ma, and W.J.G. Hellstrom Re: treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cells Eur Urol 59 2011 168 169
12. G. Lin, Y.C. Huang, and A.W. Shindel Labeling and tracking of mesenchymal stromal cells with EdU Cytotherapy 11 2009 864 873
13. T.M. Fandel, A.J. Bella, and G. Lin Intracavernous growth differentiation factor-5 therapy enhances the recovery of erectile function in a rat model of cavernous nerve injury J Sex Med 5 2008 1866 1875
14. M. Albersen, T.M. Fandel, and H. Zhang Pentoxifylline promotes recovery of erectile function in a rat model of postprostatectomy erectile dysfunction Eur Urol 59 2011 286 296
15. M.M. Garcia, T.M. Fandel, and G. Lin Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cells J Sex Med 7 2010 89 98
16. Y.C. Huang, H. Ning, and A.W. Shindel The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat model J Sex Med 7 2010 1391 1400
17. A. Laurikainen, J.O. Hiltunen, S. Vanhatalo, E. Klinge, and M. Saarma Glial cell line-derived neurotrophic factor is expressed in penis of adult rat and retrogradely transported in penile parasympathetic and sensory nerves Cell Tissue Res 302 2000 321 329
18. P. Dubovy, I. Klusáková, I. Svízenská, and V. Brázda Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic nerve injury as a model of neuropathic pain Histochem Cell Biol 133 2010 323 337
19. N. Ahmadian Kia, A.R. Bahrami, and M. Ebrahimi Comparative analysis of chemokine receptor's expression in mesenchymal stem cells derived from human bone marrow and adipose tissue J Mol Neurosci 44 2011 178 185
20. A. George, A. Buehl, and C. Sommer Wallerian degeneration after crush injury of rat sciatic nerve increases endo- and epineurial tumor necrosis factor-alpha protein Neurosci Lett 372 2004 215 219 (Pubitemid 39470199)
21. R. Martini, S. Fischer, R. López-Vales, and S. David Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease Glia 56 2008 1566 1577
22. H. Zhang, R. Yang, Z. Wang, G. Lin, T.F. Lue, and C.S. Lin Adipose tissue-derived stem cells secrete CXCL5 cytokine with neurotrophic effects on cavernous nerve regeneration J Sex Med 8 2011 437 446
23. D.F. Kalbermatten, D. Schaakxs, P.J. Kingham, and M. Wiberg Neurotrophic activity of human adipose stem cells isolated from deep and superficial layers of abdominal fat Cell Tissue Res 344 2011 251 260
24. B. Tan, Z. Luan, and X. Wei AMP-activated kinase mediates adipose stem cell-stimulated neuritogenesis of PC12 cells Neuroscience 181 2011 40 47