Differential expression of nephrin according to glomerular size in early diabetic kidney disease

Journal of the American Society of Nephrology

Volumn 18, Issue 8, 2007, Pages 2303-2310

  Kim, Jin Ju ^a   Jin, Ji Li ^a,b   Jung, Dong Sub ^a   Kwak, Seung Jae ^a   Ryu, Dong Ryeol ^c   Yoo, Tae Hyun ^a   Seung, Hyeok Han ^a   Hoon, Young Choi ^a   Hyung, Jong Kim ^d   Dae, Suk Han ^a   Kang, Shin Wook ^a  

^a Yonsei University College of Medicine   (South Korea)

^b YANBIAN UNIVERSITY MEDICAL COLLEGE   (China)

^c Ewha Womans University School of Medicine   (South Korea)

^d CHA University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NEPHRIN; PROTEIN; RNA 18S;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ELECTRON MICROSCOPY; GLOMERULUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES;

EID: 34547616609     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2006101145     Document Type: Article

References (40)

1. United States Renal Data System 2005 annual data report: Incidence and prevalence. Am J Kidney Dis 47[Suppl 1]: 65-80, 2006
2. Mogensen CE, Christensen CK, Vittinghus E: The stages in diabetic renal disease. With emphasis on the stage of incipient diabetic nephropathy. Diabetes 32[Suppl 2]: 64-78, 1983
3. Olson JL, Rennke HG, Venkatachalam MA: Alterations in the charge and size selectivity barrier of the glomerular filter in aminonucleoside nephrosis in rats. Lab Invest 44: 271-279, 1981
4. Myers BD, Okarma TB, Friedman S, Bridges C, Ross J, Asseff S, Deen WM: Mechanisms of proteinuria in human glomerulonephritis. J Clin Invest 70: 732-746, 1982
5. Daniels BS, Deen WM, Mayer G, Meyer T, Hostetter TH: Glomerular permeability barrier in the rat. Functional assessment by in vitro methods. J Clin Invest 92: 929-936, 1993
6. Guasch A, Deen WM, Myers BD: Charge selectivity of the glomerular filtration barrier in healthy and nephrotic humans. J Clin Invest 92: 2274-2282, 1993
7. Ota Z, Shikata K, Ota K: Nephrotic tunnels in glomerular basement membrane as revealed by a new electron microscopic method. J Am Soc Nephrol 4: 1965-1973, 1994
8. Tryggvason K, Wartiovaara J: Molecular basis of glomerular permselectivity. Curr Opin Nephrol Hypertens 10: 543-549, 2001
9. Kestila M, Lenkkeri U, Mannikko M, Lamerdin J, McCready P, Putaala H, Ruotsalainen V, Morita T, Nissinen M, Herva R, Kashtan CE, Peltonen L, Holmberg C, Olsen A, Tryggvason K: Positionally cloned gene for a novel glomerular protein-nephrin is mutated in congenital nephrotic syndrome. Mol Cell 1: 575-582, 1998
10. Holzman LB, St. John PL, Kovari IA, Verma R, Holthofer H, Abrahamson DR: Nephrin localizes to the slit pore of the glomerular epithelial cell. Kidney Int 56: 1481-1491, 1999
11. Ruotsalainen V, Ljungberg P, Wartiovaara J, Lenkkeri U, Kestila M, Jalanko H, Holmberg C, Tryggvason K: Nephrin is specifically located at the slit diaphragm of glomerular podocytes. Proc Natl Acad Sci U S A 96: 7962-7967, 1999
12. Luimula P, Ahola H, Wang SX, Solin ML, Aaltonen P, Tikkanen I, Kerjaschki D, Holthofer H: Nephrin in experimental glomerular disease. Kidney Int 58: 1461-1468, 2000
13. Aaltonen P, Luimula P, Astrom E, Palmen T, Gronholm T, Palojoki E, Jaakkola I, Ahola H, Tikkanen I, Holthofer H: Changes in the expression of nephrin gene and protein in experimental diabetic nephropathy. Lab Invest 81: 1185-1190, 2001
14. Bonnet F, Cooper ME, Kawachi H, Allen TJ, Boner G, Cao Z: Irbesartan normalises the deficiency in glomerular nephrin expression in a model of diabetes and hypertension. Diabetologia 44: 874-877, 2001
15. Doublier S, Ruotsalainen V, Salvidio G, Lupia E, Biancone L, Conaldi PG, Reponen P, Tryggvason K, Camussi G: Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome. Am J Pathol 158: 1723-1731, 2001
16. Patrakka J, Ruotsalainen V, Ketola I, Holmberg C, Heikinheimo M, Tryggvason K, Jalanko H: Expression of nephrin in pediatric kidney diseases. J Am Soc Nephrol 12: 289-296, 2001
17. Doublier S, Salvidio G, Lupia E, Ruotsalainen V, Verzola D, Deferrari G, Camussi G: Nephrin expression is reduced in human diabetic nephropathy: Evidence for a distinct role for glycated albumin and angiotensin II. Diabetes 52: 1023-1030, 2003
18. Schaefer L, Ren S, Schaefer RM, Mihalik D, Babelova A, Huwiler A, Pfeilschifter J: Nephrin expression is increased in anti-Thy1.1-induced glomerulonephritis in rats. Biochem Biophys Res Commun 324: 247-254, 2004
19. Toyoda M, Suzuki D, Umezono T, Uehara G, Maruyama M, Honma M, Sakai T, Sakai H: Expression of human nephrin mRNA in diabetic nephropathy. Nephrol Dial Transplant 19: 380-385, 2004
20. Rodewald R, Karnovsky MJ: Porous substructure of the glomerular slit diaphragm in the rat and mouse. J Cell Biol 60: 423-433, 1974
21. Langham RG, Kelly DJ, Cox AJ, Gow RM, Holthofer H, Gilbert RE: Angiotensin II-induced proteinuria and expression of the podocyte slit pore membrane protein, nephrin. Nephrol Dial Transplant 19: 262-263, 2004
22. Baumgartl HJ, Sigl G, Banholzer P, Haslbeck M, Standi E: On the prognosis of IDDM patients with larger kidneys. Nephrol Dial Transplant 13: 630-634, 1998
23. Toyota E, Ogasawara Y, Fujimoto K, Kajita T, Shigeto F, Asano T, Watanabe N, Kajiya F: Global heterogeneity of glomerular volume distribution in early diabetic nephropathy. Kidney Int 66: 855-861, 2004
24. Gambara V, Mecca G, Remuzzi G, Bertani T: Heterogeneous nature of renal lesions in type II diabetes. J Am Soc Nephrol 3: 1458-1466, 1993
25. Dalla Vestra M, Sailer A, Bortoloso E, Mauer M, Fioretto P: Structural involvement in type 1 and type 2 diabetic nephropathy. Diabetes Metab 26[Suppl 4]: 8-14, 2000
26. Sanden SK, Wiggins JE, Goyal M, Riggs LK, Wiggins RC: Evaluation of a thick and thin section method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with Wilms' tumor-1 protein used as a podocyte nuclear marker. J Am Soc Nephrol 14: 2484-2493, 2003
27. Artacho-Perula E, Roldan-Villalobos R, Salcedo-Leal I, Vaamonde-Lemos R: Stereological estimates of volume-weighted mean glomerular volume in streptozotocin-diabetic rats. Lab Invest 68: 56-61, 1993
28. Steffes MW, Schmidt D, McCrery R, Basgen JM: Glomerular cell number in normal subjects and in type 1 diabetic patients. Kidney Int 59: 2104-2113, 2001
29. Pagtalunan ME, Miller PL, Jumping-Eagle S, Nelson RG, Myers BD, Rennke HG, Coplon NS, Sun L, Meyer TW: Podocyte loss and progressive glomerular injury in type II diabetes. J Clin Invest 99: 342-348, 1997
30. Kreisberg JL, Hoover RL, Karnovsky MJ: Isolation and characterization of rat glomerular epithelial cells. Kidney Int 14: 21-30, 1978
31. Benzing T: Signaling at the slit diaphragm. J Am Soc Nephrol 15: 1382-1391, 2004
32. Huber TB, Benzing T: The slit diaphragm: A signaling platform to regulate podocyte function. Curr Opin Nephrol Hypertens 14: 211-216, 2005
33. Wagner N, Wagner KD, Xing Y, Scholz H, Schedl A: The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1. J Am Soc Nephrol 15: 3044-3051, 2004
34. Berg UB, Torbjornsdotter TB, Jaremko G, Thalme B: Kidney morphological changes in relation to long-term renal function and metabolic control in adolescents with IDDM. Diabetologia 41: 1047-1056, 1998
35. Mifsud SA, Allen TJ, Bertram JF, Hulthen UL, Kelly DJ, Cooper ME, Wilkinson-Berka JL, Gilbert RE: Podocyte foot process broadening in experimental diabetic nephropathy: Amelioration with renin-angiotensin blockade. Diabetologia 44: 878-882, 2001
36. Koop K, Eikmans M, Baelde HJ, Kawachi H, De Heer E, Paul LC, Bruijn JA: Expression of podocyte-associated molecules in acquired human kidney diseases. J Am Soc Nephrol 14: 2063-2071, 2003
37. Li B, Yao J, Kawamura K, Oyanagi-Tanaka Y, Hoshiyama M, Morioka T, Gejyo F, Uchiyama M, Oite T: Real-time observation of glomerular hemodynamic changes in diabetic rats: Effects of insulin and ARB. Kidney Int 66: 1939-1948, 2004
38. Kang SW, Adler SG, Nast CC, LaPage J, Gu JL, Nadler JL, Natarajan R: 12-lipoxygenase is increased in glucose-stimulated mesangial cells and in experimental diabetic nephropathy. Kidney Int 59: 1354-1362, 2001
39. Osawa G, Kimmelstiel P, Seiling V: Thickness of glomerular basement membranes. Am J Clin Pathol 45: 7-20, 1996
40. Basgen JM, Nicholas SB, Mauer M, Rozen S, Nyengaard JR: Comparison of methods for counting cells in the mouse glomerulus. Nephron Exp Nephrol 103: 139-148, 2006