Circulating CD4+CD25high regulatory T cells and expression of PD-1 and BTLA on CD4+ T cells in patients with chronic hepatitis B virus infection

Viral Immunology

Volumn 23, Issue 1, 2010, Pages 63-70

  Nan, Xue Ping ^a   Zhang, Ye ^a   Yu, Hai Tao ^a   Li, Yu ^a   Sun, Rui Lin ^a   Wang, Jiu Ping ^a   Bai, Xue Fan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

B AND T LYMPHOCYTE ATTENUATOR PROTEIN; CD4 ANTIGEN; DNA; INTERLEUKIN 2 RECEPTOR ALPHA; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BTLA PROTEIN, HUMAN; IMMUNOGLOBULIN RECEPTOR; LEUKOCYTE ANTIGEN; PDCD1 PROTEIN, HUMAN; VIRUS DNA;

ADOLESCENT; ADULT; ARTICLE; BLOOD LEVEL; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; MALE; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; VIRUS LOAD; BIOSYNTHESIS; BLOOD; CHEMISTRY; GENE EXPRESSION; HOSPITALIZATION; IMMUNOLOGY; ISOLATION AND PURIFICATION; MIDDLE AGED;

HEPATITIS B VIRUS;

ADOLESCENT; ADULT; ANTIGENS, CD; ANTIGENS, CD4; APOPTOSIS REGULATORY PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; DNA, VIRAL; FEMALE; GENE EXPRESSION; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MALE; MIDDLE AGED; RECEPTORS, IMMUNOLOGIC; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTES, REGULATORY; VIRAL LOAD; YOUNG ADULT;

EID: 76449096344     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.2009.0061     Document Type: Article

References (41)

1. Aseffa A, Gumy A, Launois P, MacDonald HR, Louis JA, and Tacchini-Cottier F: The early IL-4 response to Leishmania major and the resulting Th2 cell maturation steering progressive disease in BALB=c mice are subject to the control of regulatory CD4+CD25+T cells. J Immunol 2002;169:3232-3241.
2. Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, and Sacks DL: CD4+CD25+regulatory T cells control Leishmania major persistence and immunity. Nature 2002;420:502-507.
3. Bolacchi F, Sinistro A, Ciaprini C, et al.: Increased hepatitis C virus (HCV)-specific CD4+CD25+regulatory T lymphocytes and reduced HCV-specific CD4+T cell response in HCVinfected patients with normal versus abnormal alanine aminotransferase levels. Clin Exp Immunol 2006;144:188-196.
4. Boni C, Bertoletti A, Penna A, et al.: Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B. J Clin Invest 1998;102:968-975.
5. Boni C, Fisicaro P, Valdatta C, et al.: Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J Virol 2007;81:4215-4225.
6. Boni C, Penna A, Ogg GS, et al.: Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy. Hepatology 2001;33:963-971.
7. Carreno BM, and Collins M: BTLA: a new inhibitory receptor with a B7-like ligand. Trends Immunol 2003;24:524-527.
8. Chen L: Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 2004;4:336-347. (Pubitemid 38649276)
9. Chisari FV, and Ferrari C: Hepatitis B virus immunopathogenesis. Annu Rev Immunol 1995;13:29-60.
10. Evans A, Riva A, Cooksley H, et al.: Programmed death 1 expression during antiviral treatment of chronic hepatitis B: Impact of hepatitis B e-antigen seroconversion. Hepatology 2008;48:759-769.
11. Franceschini D, Paroli M, Francavilla V, et al.: PD-L1 negatively regulates CD4+CD25+Foxp3+Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. J Clin Invest 2009;119:551-564.
12. Franzese O, Kennedy PT, Gehring AJ, Gotto J, Williams R, Maini MK, and Bertoletti A: Modulation of the CD8+-T-cell response by CD4+CD25+regulatory T cells in patients with hepatitis B virus infection. J Virol 2005;79:3322-3328.
13. Greenwald RJ, Freeman GJ, and Sharpe AH: The B7 family revisited. Annu Rev Immunol 2005;23:515-548.
14. Hori S, Carvalho TL, and Demengeot J: CD25+CD4+ regulatory T cells suppress CD4+T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice. Eur J Immunol 2002;32:1282-1291.
15. Iwashiro M, Messer RJ, Peterson KE, Stromnes IM, Sugie T, and Hasenkrug KJ: Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection. Proc Natl Acad Sci USA 2001;98:9226-9230.
16. Jiang H, and Chess L: An integrated view of suppressor T cell subsets in immunoregulation. J Clin Invest 2004;114: 1198-1208. (Pubitemid 40385287)
17. Jung MC, and Pape GR: Immunology of hepatitis B infection. Lancet Infect Dis 2002;2:43-50.
18. Kinter AL, Hennessey M, Bell A, et al.: CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J Exp Med 2004;200:331-343.
19. Leibson PJ: The regulation of lymphocyte activation by inhibitory receptors. Curr Opin Immunol 2004;16:328-336.
20. Lok AS, and McMahon BJ: Chronic hepatitis B. Hepatology 2001;34:1225-1241.
21. Montagnoli C, Bacci A, Bozza S, Gaziano R, Mosci P, Sharpe AH, and Romani L: B7=CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memoryprotective immunity to Candida albicans. J Immunol 2002; 169:6298-6308.
22. Okazaki T, and Honjo T: The PD-1-PD-L pathway in immunological tolerance. Trends Immunol 2006;27:195-201.
23. Peng G, Li S, Wu W, Tan X, Chen Y, and Chen Z: PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients. Mol Immunol 2008; 45:963-970.
24. Piccirillo CA, and Thornton AM: Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+regulatory T cells. Trends Immunol 2004;25:374-380.
25. Raghavan S, Suri-Payer E, and Holmgren J: Antigen-specific in vitro suppression of murine Helicobacter pylori-reactive immunopathological T cells by CD4CD25 regulatory T cells. Scand J Immunol 2004;60:82-88.
26. Rehermann B, and Naoumov NV: Immunological techniques in viral hepatitis. J Hepatol 2007;46:508-520.
27. Sakaguchi S: Naturally arising CD4+regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004;22:531-562.
28. Sakaguchi S: Naturally arising Foxp3-expressing CD25+ CD4+regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005;6:345-352.
29. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, and Toda M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-1164.
30. Shevach EM: Regulatory T cells in autoimmmunity. Annu Rev Immunol 2000;18:423-449.
31. Singh B, Read S, Asseman C, et al.: Control of intestinal inflammation by regulatory T cells. Immunol Rev 2001;182: 190-200.
32. Stoop JN, van der Molen RG, Baan CC, van der Laan LJ, Kuipers EJ, Kusters JG, and Janssen HL: Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 2005;41:771-778.
33. Stoop JN, van der Molen RG, Kuipers EJ, Kusters JG, and Janssen HL: Inhibition of viral replication reduces regulatory T cells and enhances the antiviral immune response in chronic hepatitis B. Virology 2007;361:141-148.
34. Takahashi T, Kuniyasu Y, Toda M, et al.: Immunologic selftolerance maintained by CD25+CD4+naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic=suppressive state. Int Immunol 1998; 10:1969-1980.
35. Tsunemi S, Iwasaki T, Imado T, Higasa S, Kakishita E, Shirasaka T, and Sano H: Relationship of CD4+CD25+ regulatory T cells to immune status in HIV-infected patients. AIDS 2005;19:879-886.
36. Wang XF, Chen YJ, Wang Q, et al.: Distinct expression and inhibitory function of B and T lymphocyte attenuator on human T cells. Tissue Antigens 2007;69:145-153.
37. Watanabe N, Gavrieli M, Sedy JR, et al.: BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol 2003;4:670-679.
38. Webster GJ, Reignat S, Maini MK, et al.: Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology 2000;32:1117-1124.
39. Xu D, Fu J, Jin L, et al.: Circulating and liver resident CD4+CD25+regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol 2006;177:739-747.
40. Xu D, Liu H, Komai-Koma M, Campbell C, McSharry C, Alexander J, and Liew FY: CD4+CD25+regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J Immunol 2003;170:394-399.
41. Yang G, Liu A, Xie Q, Guo TB, Wan B, Zhou B, and Zhang JZ: Association of CD4+CD25+Foxp3+regulatory T cells with chronic activity and viral clearance in patients with hepatitis B. Int Immunol 2007;19:133-140.