Niemann-pick c1 mice, a model of "juvenile alzheimer's disease", with normal gene expression in neurons and fibrillary astrocytes show long term survival and delayed neurodegeneration

Journal of Alzheimer's Disease

Volumn 30, Issue 4, 2012, Pages 875-887

  Borbon, Ivan ^a   Totenhagen, John ^b   Fiorenza, Maria Teresa ^c   Canterini, Sonia ^c   Ke, Wangjing ^a   Trouard, Theodore ^b   Erickson, Robert P ^a,d  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d University of Arizona   (United States)

Author keywords

Astrocyte specific gene expression; cell autonomy; intracellular cholesterol transport; neurodegeneration; neuron specific gene expression

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; NEURON SPECIFIC ENOLASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CELL DEGENERATION; CELL LOSS; CONTROLLED STUDY; GENE EXPRESSION; LIFESPAN; LONG TERM SURVIVAL; MACROPHAGE; MEMORY; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MOUSE; MYELINATION; NERVE CELL; NERVE DEGENERATION; NEUROLOGIC DISEASE; NIEMANN PICK DISEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; PRIORITY JOURNAL; PURKINJE CELL; TRANSGENE; TRANSGENICS; WEIGHT GAIN;

EID: 84863005612     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-120199     Document Type: Article

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