Rescue of neurodegeneration in Niemann-Pick C mice by a prion-promoter-driven Npc1 cDNA transgene

Human Molecular Genetics

Volumn 11, Issue 24, 2002, Pages 3107-3114

  Loftus, Stacie K ^a   Erickson, Robert P ^b,c   Walkley, Steven U ^d   Bryant, Mark A ^e   Incao, Arturo ^a   Heidenreich, Randall A ^b   Pavan, William J ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c The University of Arizona   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GANGLIOSIDE GM2; GANGLIOSIDE GM3; MEMBRANE PROTEIN; PROTEIN NPC1; UNCLASSIFIED DRUG; NPC1 PROTEIN, MOUSE; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE THERAPY; GLIA CELL; HISTIOCYTOSIS; INFERTILITY; LIFESPAN; LIPID STORAGE; LIVER; MALE; MOUSE; NERVE CELL; NERVE DEGENERATION; NIEMANN PICK DISEASE; NONHUMAN; PHENOTYPE; PRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN; TRANSGENIC ANIMAL; VISCERA; WILD TYPE; ANIMAL; ANTIBODY SPECIFICITY; BRAIN; CYTOLOGY; DISEASE MODEL; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; PROMOTER REGION; WEIGHT REDUCTION;

ANIMALIA; MUS MUSCULUS;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; EMACIATION; GENE THERAPY; IMMUNOHISTOCHEMISTRY; INFERTILITY; MICE; NIEMANN-PICK DISEASES; ORGAN SPECIFICITY; PRIONS; PROMOTER REGIONS (GENETICS); PROTEINS;

EID: 1842836379     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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