-
2
-
-
79952698455
-
Denosumab and bisphosphonates: Different mechanisms of action and effects
-
Baron R, Ferrari S, Russell RG. Denosumab and bisphosphonates: different mechanisms of action and effects. Bone 2011; 48 (4): 677-692.
-
(2011)
Bone
, vol.48
, Issue.4
, pp. 677-692
-
-
Baron, R.1
Ferrari, S.2
Russell, R.G.3
-
3
-
-
0023612183
-
Murine osteo blastlike cells and the osteogenic cell MC3T3-E1 release a macrophage colony-stimulating activity in culture
-
Elford PR, Felix R, Cecchini M et al. Murine osteo blastlike cells and the osteogenic cell MC3T3-E1 release a macrophage colony-stimulating activity in culture. Calcif Tissue Int 1987; 41 (3): 151-156.
-
(1987)
Calcif Tissue Int
, vol.41
, Issue.3
, pp. 151-156
-
-
Elford, P.R.1
Felix, R.2
Cecchini, M.3
-
4
-
-
0025332897
-
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
-
Yoshida H, Hayashi S, Kunisada T et al. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 1990; 345 (6274): 442-444. (Pubitemid 120014957)
-
(1990)
Nature
, vol.345
, Issue.6274
, pp. 442-444
-
-
Yoshida, H.1
Hayashi, S.-I.2
Kunisada, T.3
Ogawa, M.4
Nishikawa, S.5
Okamura, H.6
Sudo, T.7
Shultz, L.D.8
Nishikawa, S.-I.9
-
5
-
-
0032540319
-
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
-
DOI 10.1016/S0092-8674(00)81569-X
-
Lacey DL, Timms E, Tan HL et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998; 93 (2): 165-176. (Pubitemid 28180851)
-
(1998)
Cell
, vol.93
, Issue.2
, pp. 165-176
-
-
Lacey, D.L.1
Timms, E.2
Tan, H.-L.3
Kelley, M.J.4
Dunstan, C.R.5
Burgess, T.6
Elliott, R.7
Colombero, A.8
Elliott, G.9
Scully, S.10
Hsu, H.11
Sullivan, J.12
Hawkins, N.13
Davy, E.14
Capparelli, C.15
Eli, A.16
Qian, Y.-X.17
Kaufman, S.18
Sarosi, I.19
Shalhoub, V.20
Senaldi, G.21
Guo, J.22
Delaney, J.23
Boyle, W.J.24
more..
-
6
-
-
0033611467
-
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
-
Kong YY, Yoshida H, Sarosi I et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999; 397 (6717): 315-323.
-
(1999)
Nature
, vol.397
, Issue.6717
, pp. 315-323
-
-
Kong, Y.Y.1
Yoshida, H.2
Sarosi, I.3
-
7
-
-
9244252016
-
The molecular triad OPG/RANK/RANKL: Involvement in the orchestration of pathophysiological bone remodeling
-
DOI 10.1016/j.cytogfr.2004.06.004, PII S1359610104000747
-
Theoleyre S, Wittrant Y, Tat SK et al. The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling. Cytokine Growth Factor Rev 2004; 15 (6): 457-475. (Pubitemid 39550455)
-
(2004)
Cytokine and Growth Factor Reviews
, vol.15
, Issue.6
, pp. 457-475
-
-
Theoleyre, S.1
Wittrant, Y.2
Tat, S.K.3
Fortun, Y.4
Redini, F.5
Heymann, D.6
-
8
-
-
67349272085
-
RANK, RANKL and osteoprotegerin in bone biology and disease
-
Wright HL, McCarthy HS, Middleton J, Marshall MJ. RANK, RANKL and osteoprotegerin in bone biology and disease. Curr Rev Musculoskelet Med 2009; 2 (1): 56-64.
-
(2009)
Curr Rev Musculoskelet Med
, vol.2
, Issue.1
, pp. 56-64
-
-
Wright, H.L.1
McCarthy, H.S.2
Middleton, J.3
Marshall, M.J.4
-
9
-
-
58549115903
-
Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate
-
Pederson L, Ruan M, Westendorf JJ et al. Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1- phosphate. Proc Natl Acad Sci USA 2008; 105 (52): 20764-20769.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.52
, pp. 20764-20769
-
-
Pederson, L.1
Ruan, M.2
Westendorf, J.J.3
-
10
-
-
33746528704
-
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis
-
DOI 10.1016/j.cmet.2006.05.012, PII S1550413106002038
-
Zhao C, Irie N, Takada Y et al. Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab 2006; 4 (2): 111-121. (Pubitemid 44138718)
-
(2006)
Cell Metabolism
, vol.4
, Issue.2
, pp. 111-121
-
-
Zhao, C.1
Irie, N.2
Takada, Y.3
Shimoda, K.4
Miyamoto, T.5
Nishiwaki, T.6
Suda, T.7
Matsuo, K.8
-
11
-
-
79952693900
-
EPHs and ephrins: Many pathways to regulate osteoblasts and osteoclasts
-
Sims NA. EPHs and ephrins: many pathways to regulate osteoblasts and osteoclasts. IBMS Bone-KEy 2010; 7: 304-313.
-
(2010)
IBMS Bone-KEy
, vol.7
, pp. 304-313
-
-
Sims, N.A.1
-
12
-
-
79958695940
-
Bisphosphonates: The first 40 years
-
Russell RG. Bisphosphonates: the first 40 years. Bone 2011; 49 (1): 2-19.
-
(2011)
Bone
, vol.49
, Issue.1
, pp. 2-19
-
-
Russell, R.G.1
-
13
-
-
79958700323
-
The relationship between the chemistry and biological activity of the bisphosphonates
-
Ebetino FH, Hogan AM, Sun S et al. The relationship between the chemistry and biological activity of the bisphosphonates. Bone 2011; 49 (1): 20-33.
-
(2011)
Bone
, vol.49
, Issue.1
, pp. 20-33
-
-
Ebetino, F.H.1
Hogan, A.M.2
Sun, S.3
-
14
-
-
43049109229
-
Mechanisms of action of bisphosphonates: Similarities and differences and their potential influence on clinical efficacy
-
Russell RG, Watts NB, Ebetino FH, Rogers MJ. Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int 2008; 19 (6): 733-759.
-
(2008)
Osteoporos Int
, vol.19
, Issue.6
, pp. 733-759
-
-
Russell, R.G.1
Watts, N.B.2
Ebetino, F.H.3
Rogers, M.J.4
-
15
-
-
34548401627
-
Clinical development of anti-RANKL therapy
-
Schwarz EM, Ritchlin CT. Clinical development of anti-RANKL therapy. Arthritis Res Ther 2007; 9 (Suppl 1): S7.
-
(2007)
Arthritis Res Ther
, vol.9
, Issue.SUPPL. 1
-
-
Schwarz, E.M.1
Ritchlin, C.T.2
-
16
-
-
34347394402
-
The RANKL inhibitor OPG-Fc increases cortical and trabecular bone mass in young gonad-intact cynomolgus monkeys
-
DOI 10.1007/s00198-007-0363-7
-
Ominsky MS, Kostenuik PJ, Cranmer P et al. The RANKL inhibitor OPG-Fc increases cortical and trabecular bone mass in young gonad-intact cynomolgus monkeys. Osteoporos Int 2007; 18 (8): 1073-1082. (Pubitemid 47020009)
-
(2007)
Osteoporosis International
, vol.18
, Issue.8
, pp. 1073-1082
-
-
Ominsky, M.S.1
Kostenuik, P.J.2
Cranmer, P.3
Smith, S.Y.4
Atkinson, J.E.5
-
17
-
-
0037303260
-
Rank-Fc: A therapeutic antagonist for RANK-L in myeloma
-
Sordillo EM, Pearse RN. RANK-Fc: a therapeutic antagonist for RANK-L in myeloma. Cancer 2003; 97 (Suppl 3): 802-812. (Pubitemid 36125816)
-
(2003)
Cancer
, vol.97
, Issue.3 SUPPL.
, pp. 802-812
-
-
Sordillo, E.M.1
Pearse, R.N.2
-
18
-
-
58649113384
-
Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL
-
Kostenuik PJ, Nguyen HQ, McCabe J et al. Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL. J Bone Miner Res 2009; 24 (2): 182-195.
-
(2009)
J Bone Miner Res
, vol.24
, Issue.2
, pp. 182-195
-
-
Kostenuik, P.J.1
Nguyen, H.Q.2
McCabe, J.3
-
19
-
-
7344233085
-
Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL
-
DOI 10.1074/jbc.273.23.14363
-
Emery JG, McDonnell P, Burke MB et al. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem 1998; 273 (23): 14363-14367. (Pubitemid 28319153)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.23
, pp. 14363-14367
-
-
Emery, J.G.1
McDonnell, P.2
Burke, M.B.3
Deen, K.C.4
Lyn, S.5
Silverman, C.6
Dul, E.7
Appelbaum, E.R.8
Eichman, C.9
DiPrinzio, R.10
Dodds, R.A.11
James, I.E.12
Rosenberg, M.13
Lee, J.C.14
Young, P.R.15
-
20
-
-
32444438731
-
Elimination mechanisms of therapeutic monoclonal antibodies
-
DOI 10.1016/S1359-6446(05)03638-X, PII S135964460503638X
-
Tabrizi MA, Tseng CM, Roskos LK. Elimination mechanisms of therapeutic monoclonal antibodies. Drug Discov Today 2006; 11 (1-2): 81-88. (Pubitemid 43227856)
-
(2006)
Drug Discovery Today
, vol.11
, Issue.1-2
, pp. 81-88
-
-
Tabrizi, M.A.1
Tseng, C.-M.L.2
Roskos, L.K.3
-
21
-
-
77956246270
-
Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL
-
Pierroz DD, Bonnet N, Baldock PA et al. Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL. J Biol Chem 2010; 285 (36): 28164-28173.
-
(2010)
J Biol Chem
, vol.285
, Issue.36
, pp. 28164-28173
-
-
Pierroz, D.D.1
Bonnet, N.2
Baldock, P.A.3
-
22
-
-
33748199511
-
OPG/membranous-RANKL complex is internalized via the clathrin pathway before a lysosomal and a proteasomal degradation
-
DOI 10.1016/j.bone.2006.03.016, PII S8756328206004066
-
Tat SK, Padrines M, Theoleyre S et al. OPG/membranous - RANKL complex is internalized via the clathrin pathway before a lysosomal and a proteasomal degradation. Bone 2006; 39 (4): 706-715. (Pubitemid 44311705)
-
(2006)
Bone
, vol.39
, Issue.4
, pp. 706-715
-
-
Tat, S.K.1
Padrines, M.2
Theoleyre, S.3
Couillaud-Battaglia, S.4
Heymann, D.5
Redini, F.6
Fortun, Y.7
-
23
-
-
0242503684
-
New insights into the molecular mechanisms of action of bisphosphonates
-
DOI 10.2174/1381612033453640
-
Rogers MJ. New insights into the molecular mechanisms of action of bisphosphonates. Curr Pharm Des 2003; 9 (32): 2643-2658. (Pubitemid 37456015)
-
(2003)
Current Pharmaceutical Design
, vol.9
, Issue.32
, pp. 2643-2658
-
-
Rogers, M.J.1
-
24
-
-
41849119494
-
Long-term protective effects of zoledronic acid on cancellous and cortical bone in the ovariectomized rat
-
DOI 10.1359/jbmr.071207
-
Gasser JA, Ingold P, Venturiere A et al. Long-term protective effects of zoledronic acid on cancellous and cortical bone in the ovariectomized rat. J Bone Miner Res 2008; 23 (4): 544-551. (Pubitemid 351501895)
-
(2008)
Journal of Bone and Mineral Research
, vol.23
, Issue.4
, pp. 544-551
-
-
Gasser, J.A.1
Ingold, P.2
Venturiere, A.3
Shen, V.4
Green, J.R.5
-
25
-
-
70349100858
-
One year of transgenic overexpression of osteoprotegerin in rats suppressed bone resorption and increased vertebral bone volume, density, and strength
-
Ominsky MS, Stolina M, Li X et al. One year of transgenic overexpression of osteoprotegerin in rats suppressed bone resorption and increased vertebral bone volume, density, and strength. J Bone Miner Res 2009; 24 (7): 1234-1246.
-
(2009)
J Bone Miner Res
, vol.24
, Issue.7
, pp. 1234-1246
-
-
Ominsky, M.S.1
Stolina, M.2
Li, X.3
-
26
-
-
68849132198
-
Increased RANK ligand in bone marrow of orchiectomized rats and prevention of their bone loss by the RANK ligand inhibitor osteoprotegerin
-
Li X, Ominsky MS, Stolina M et al. Increased RANK ligand in bone marrow of orchiectomized rats and prevention of their bone loss by the RANK ligand inhibitor osteoprotegerin. Bone 2009; 45 (4): 669-676.
-
(2009)
Bone
, vol.45
, Issue.4
, pp. 669-676
-
-
Li, X.1
Ominsky, M.S.2
Stolina, M.3
-
27
-
-
33847721029
-
Risedronate and alendronate suppress osteocyte apoptosis following cyclic fatigue loading
-
DOI 10.1016/j.bone.2006.12.052, PII S8756328206009161
-
Follet H, Li J, Phipps RJ et al. Risedronate and alendronate suppress osteocyte apoptosis following cyclic fatigue loading. Bone 2007; 40 (4): 1172-1177. (Pubitemid 46386562)
-
(2007)
Bone
, vol.40
, Issue.4
, pp. 1172-1177
-
-
Follet, H.1
Li, J.2
Phipps, R.J.3
Hui, S.4
Condon, K.5
Burr, D.B.6
-
28
-
-
34347212822
-
Individual and combined effects of exercise and alendronate on bone mass and strength in ovariectomized rats
-
DOI 10.1016/j.bone.2007.04.179, PII S8756328207003687
-
Fuchs RK, Shea M, Durski SL et al. Individual and combined effects of exercise and alendronate on bone mass and strength in ovariectomized rats. Bone 2007; 41 (2): 290-296. (Pubitemid 47001818)
-
(2007)
Bone
, vol.41
, Issue.2
, pp. 290-296
-
-
Fuchs, R.K.1
Shea, M.2
Durski, S.L.3
Winters-Stone, K.M.4
Widrick, J.5
Snow, C.M.6
-
29
-
-
69249220036
-
Does exercise modify the effects of zoledronic acid on bone mass, microarchitecture, biomechanics, and turnover in ovariectomized rats?
-
Lespessailles E, Jaffré C, Beaupied H et al. Does exercise modify the effects of zoledronic acid on bone mass, microarchitecture, biomechanics, and turnover in ovariectomized rats? Calcif Tissue Int 2009; 85 (2): 146-157.
-
(2009)
Calcif Tissue Int
, vol.85
, Issue.2
, pp. 146-157
-
-
Lespessailles, E.1
Jaffré, C.2
Beaupied, H.3
-
30
-
-
3342982829
-
A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women
-
DOI 10.1359/JBMR.040305
-
Bekker PJ, Holloway DL, Rasmussen AS et al. A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J Bone Miner Res 2004; 19 (7): 1059-1066. (Pubitemid 41110556)
-
(2004)
Journal of Bone and Mineral Research
, vol.19
, Issue.7
, pp. 1059-1066
-
-
Bekker, P.J.1
Holloway, D.L.2
Rasmussen, A.S.3
Murphy, R.4
Martin, S.W.5
Leese, P.T.6
Holmes, G.B.7
Dunstan, C.R.8
DePaoli, A.M.9
-
31
-
-
84856364960
-
The Transitory Increase in PTH Following Denosumab Administration is Associated with Reduced Intracortical Porosity: A Distinctive Attribute of Denosumab Therapy
-
Seeman E, Libanati C, Austin M et al. The Transitory Increase in PTH Following Denosumab Administration is Associated With Reduced Intracortical Porosity: a Distinctive Attribute of Denosumab Therapy. J Bone Miner Res 2011; 26 (Suppl 1): S22.
-
(2011)
J Bone Miner Res
, vol.26
, Issue.SUPPL. 1
-
-
Seeman, E.1
Libanati, C.2
Austin, M.3
-
32
-
-
4344568083
-
Bone safety of long-term bisphosphonate treatment
-
Rodan G, Reszka A, Golub E, Rizzoli R. Bone safety of long-term bisphosphonate treatment. Curr Med Res Opin 2004; 20 (8): 1291-1300. (Pubitemid 39120794)
-
(2004)
Current Medical Research and Opinion
, vol.20
, Issue.8
, pp. 1291-1300
-
-
Rodan, G.1
Reszka, A.2
Golub, E.3
Rizzoli, R.4
-
33
-
-
84155171114
-
Pathophysiology of atypical femoral fractures and osteonecrosis of the jaw
-
Compston J. Pathophysiology of atypical femoral fractures and osteonecrosis of the jaw. Osteoporos Int 2011; 22 (12): 2951-2961.
-
(2011)
Osteoporos Int
, vol.22
, Issue.12
, pp. 2951-2961
-
-
Compston, J.1
|