Prdx1 deficiency in mice promotes tissue specific loss of heterozygosity mediated by deficiency in DNA repair and increased oxidative stress

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 735, Issue 1-2, 2012, Pages 39-45

  Rani, Vamsi ^a   Neumann, Carola A ^b   Shao, Changshun ^a   Tischfield, Jay A ^a  

^a Life Sciences Building Rutgers University   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Loss of heterozygosity; Mutations; Peroxiredoxin 1; Reactive oxygen species

Indexed keywords

PEROXIDASE; PEROXIREDOXIN 1; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL TYPE; CONTROLLED STUDY; DNA REPAIR; DOWN REGULATION; ENZYME ACTIVITY; FIBROBLAST; GENE FUNCTION; GENE MUTATION; GENE SEQUENCE; HETEROZYGOSITY LOSS; IN VIVO STUDY; MALE; MITOTIC RECOMBINATION; MOUSE; MUTATION RATE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SOMATIC CELL; SPLEEN CELL; T LYMPHOCYTE; TISSUE SPECIFICITY; TUMOR SUPPRESSOR GENE;

ANIMALS; DNA REPAIR; EAR; FIBROBLASTS; LOSS OF HETEROZYGOSITY; MALE; MICE; MUTATION; ORGAN SPECIFICITY; OXIDATIVE STRESS; PEROXIREDOXINS; REACTIVE OXYGEN SPECIES; SPLEEN; T-LYMPHOCYTES;

MUS;

EID: 84862997540     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2012.04.004     Document Type: Article

References (30)

1. Yoshizumi M., Tsuchiya K., Tamaki T. Signal transduction of reactive oxygen species and mitogen-activated protein kinases in cardiovascular disease. J. Med. Invest. 2001, 48:11-24.
2. Claiborne A., Yeh J.I., Mallett T.C., Luba J., Crane E.J., Charrier V., Parsonage D. Protein-sulfenic acids: diverse roles for an unlikely player in enzyme catalysis and redox regulation. Biochemistry 1999, 38:15407-15416.
3. Neumann C.A., Cao J., Manevich Y. Peroxiredoxin 1 and its role in cell signaling. Cell Cycle 2009, 8:4072-4078.
4. Cadet J., Berger M., Douki T., Ravanat J.L. Oxidative damage to DNA: formation, measurement, and biological significance. Rev. Phys. Biochem. Pharm. 1997, 131:1-87.
5. Díaz-Llera S., Podlutsky A., Osterholm A.M., Hou S.M., Lambert B. Hydrogen peroxide induced mutations at the HPRT locus in primary human T-lymphocytes. Mutat. Res. 2000, 469:51-61.
6. Neumann C.A., Krause D.S., Carman C.V., Das S., Dubey D.P., Abraham J.L., Bronson R.T., Fujiwara Y., Orkin S.H., Van Etten R.A. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature 2003, 424:561-565.
7. Egler R.A., Fernandes E., Rothermund K., Sereika S., de Souza-Pinto N., Jaruga P., Dizdaroglu M., Prochownik E.V. Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1. Oncogene 2005, 24:8038-8050.
8. Turker M.S., Gage B.M., Rose J.A., Elroy D., Ponomareva O.N., Stambrook P.J., Tischfield J.A. A novel signature mutation for oxidative damage resembles a mutational pattern found commonly in human cancers. Cancer Res. 1999, 59:1837-1839.
9. Turner D.R., Dreimanis M., Holt D., Firgaira F.A., Morley A.A. Mitotic recombination is an important mutational event following oxidative damage. Mutat. Res. 2003, 522:21-26.
10. Knudson A.G. Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. U. S. A. 1971, 68:820-823.
11. Shao C., Deng L., Henegariu O., Liang L., Raikwar N., Sahota A., Stambrook P.J., Tischfield J.A. Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:9230-9235.
12. Shao C., Deng L., Chen Y., Kucherlapati R., Stambrook P.J., Tischfield J.A. Mlh1 mediates tissue-specific regulation of mitotic recombination. Oncogene 2004, 23:9017-9024.
13. Shao C., Deng L., Henegariu O., Liang L., Stambrook P.J., Tischfield J.A. Chromsome instability contributes to loss of heterozygosity in mice lacking p53. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:7405-7410.
14. Meng Q., Skopek T.R., Walker D.M., Hurley-Leslie S., Chen T., Zimmer D.M., Walker V.E. Culture and propagation of Hprt mutant T-lymphocytes isolated from mouse spleen. Environ. Mol. Mutagen. 1998, 32:236-243.
15. Yuan L., Inoue S., Saito Y., Nakajima O. An evaluation of the effects of cytokines on intracellular oxidative production in normal neutrophils by flow cytometry. Exp. Cell Res. 1993, 209:375-381.
16. Huo Y.Y., Li G., Duan R.F., Gou Q., Fu C.L., Hu Y.C., Song B.Q., Yang Z.H., Wu D.C., Zhou P.K. PTEN deletion leads to deregulation of antioxidants and increased oxidative damage in mouse embryonic fibroblasts. Free Radic. Biol. Med. 2008, 44:1578-1591.
17. Cao J., Schulte J., Knight A., Leslie N.R., Zagozdzon A., Bronson R., Manevich Y., Beeson C., Neumann C.A. Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity. EMBO J. 2009, 28:1505-1517.
18. Shen W.H., Balajee A.S., Wang J., Wu H., Eng C., Pandolfi P.P., Yin Y. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 2007, 128:157-170.
19. 2 in mammalian cells. Radiat. Res. 2008, 170:784-793.
20. Harfe B.D., Jinks-Robertson.S. DNA mismatch repair and genetic instability. Annu. Rev. Genet. 2000, 34:359-399.
21. Jiricny J. The multifaceted mismatch-repair system. Nat. Rev. Mol. Cell. Biol. 2006, 7:335-346.
22. Herman J.G., Umar A., Polyak K., Graff J.R., Ahuja N., Issa J.P., Markowitz S., Willson J.K., Hamilton S.R., Kinzler K.W., Kane M.F., Kolodner R.D., Vogelstein B., Kunkel T.A., Baylin S.B. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:6870-6875.
23. Kane M.F., Loda M., Gaida G.M., Lipman J., Mishra R., Goldman H., Jessup J.M., Kolodner R. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res. 1997, 57:808-811.
24. Brenner C., Deplus R., Didelot C., Loriot A., Viré E., De Smet C., Gutierrez A., Danovi D., Bernard D., Boon T., Pelicci P.G., Amati B., Kouzarides T., de Launoit Y., Di Croce L., Fuks F. Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J. 2005, 24:336-346.
25. Gartel A.L. A new mode of transcriptional repression by c-myc: methylation. Oncogene 2006, 25:1989-1990.
26. Felsher D.W., Bishop J.M. Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:3940-3944.
27. Jeong W., Park S.J., Chang T.S., Lee D.Y., Rhee S.G. Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxin. J. Biol. Chem. 2006, 277:14400-14407.
28. Wood Z.A., Schröder E., Robin Harris J., Poole L.B. Structure mechanism and regulation of peroxiredoxins. Trend Biol. Sci. 2003, 28:32-40.
29. Yang K.S., Kang S.W., Woo H.A., Hwang S.C., Chae H.Z., Kim K., Rhee S.G. Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid. J. Biol. Chem. 2002, 277:38029-38036.
30. Marinkovic D., Marinkovic T., Kokai E., Barth T., Möller P., Wirth T. Identification of novel Myc target genes with a potential role in lymphomagenesis. Nucleic Acids Res. 2004, 32:5368-5378.