Hydrogen peroxide induced mutations at the HPRT locus in primary human T-lymphocytes

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 469, Issue 1, 2000, Pages 51-61

  Díaz Llera, Silvia ^a,b   Podlutsky, Andrej ^a   ̈sterholm, Anne May ^a   Hou, Sai Mei ^a   Lambert, Bo ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF HAVANA   (Cuba)

Author keywords

Hydrogen peroxide; Hypoxanthine guanine phosphoribosyltransferase (HPRT); Mutation frequency; Mutational spectra; T lymphocytes

Indexed keywords

HYDROGEN PEROXIDE; HYDROXYL RADICAL; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; DNA SEQUENCE; GENE LOCUS; GENOTOXICITY; HUMAN; HUMAN CELL; MUTAGENICITY; MUTATION RATE; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SPONTANEOUS MUTATION; T LYMPHOCYTE;

CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; DNA MUTATIONAL ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN PEROXIDE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; KINETICS; MUTAGENESIS; MUTAGENICITY TESTS; MUTAGENS; T-LYMPHOCYTES; TIME FACTORS;

MAMMALIA; PROKARYOTA;

EID: 17944402318     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(00)00058-9     Document Type: Article

References (30)

1. Burcham P.C. Internal hazards: baseline DNA damage by endogenous products of normal metabolism. Mutat. Res. 443:1999;11-36.
2. Ames B.A., Gold L.S. Endogeneous mutagens and the causes of aging and cancer. Mutat. Res. 250:1991;3-16.
3. Gracy R.W., Talent J.M., Kong Y., Conrad C.C. Reactive oxygen species: the unavoidable environmental insult. Mutat. Res. 428:1999;17-22.
4. Epe B. DNA damage profiles induced by oxidizing agents. Rev. Physiol. Biochem. Pharmacol. 127:1995;223-249.
5. Møller P., Wallin H. Adduct formation, mutagenesis and nucleotide excision repair of DNA damage produced by reactive oxygen species and lipid peroxidation product. Mutat. Res. 410:1998;271-290.
6. Henle E.S., Linn S. Formation, prevention, and repair of DNA damage by iron/hydrogen peroxide. J. Biol. Chem. 272:1997;19095-19098.
7. Cadet J., Delatour T., Douki T., Gasparutto D., Pouget J.-P., Ravanat J.-L., Sauvaigo S. Hydroxyl radicals and DNA base damage. Mutat. Res. 424:1999;9-21.
8. Meneghini R. Genotoxicity of active oxygen species in mammalian cells. Mutat. Res. 195:1988;215-230.
9. Bradley M.O., Erickson L.C. Comparison of the effects of hydrogen peroxide and X-ray irradiation on toxicity, mutation, and DNA damage/repair in mammalian cells (V-79). Biochim. Biophys. Acta. 654:1981;135-141.
10. Phillips B.J., James T.E.B., Anderson D. Genetic damage in CHO cells exposed to enzymatically generated active oxygen species. Mutat. Res. 126:1984;265-271.
11. Speit G. The relationship between the induction of SCEs and mutation in Chinese hamster cells: I. Experiments with hydrogen peroxide and caffeine. Mutat. Res. 174:1986;21-26.
12. Ziegler-Skylakakis K., Andrae U. Mutagenicity of hydrogen peroxide in V79 Chinese hamster cells. Mutat. Res. 192:1987;65-67.
13. Oller A.R., Thilly W.G. Mutational spectra in human B-cells. Spontaneous, oxygen and hydrogen peroxide-induced mutations at the hprt gene. J. Mol. Biol. 228:1992;813-826.
14. Rossman T.B., Goncharova E.I. Spontaneous mutagenesis in mammalian cells is caused mainly by oxidative events and can be blocked by antioxidants and metallothionein. Mutat. Res. 403:1998;103-110.
15. Cole J., Skopek T. Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo. Mutat. Res. 304:1994;33-106.
16. Burkhart-Schultz K.J., Thompson C.L., Jones I.M. Spectrum of somatic mutations at the hypoxanthine phosphoribosyltransferase (hprt) gene of healthy people. Carcinogenesis. 17:1996;1871-1883.
17. Podlutsky A., Österholm A.-M., Hou S.-M., Hofmaier A., Lambert B. Spectrum of point mutations in the coding region of the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene in human T-lymphocytes in vivo. Carcinogenesis. 19:1998;557-566.
18. Podlutsky A., Hou S.M., Nyberg F., Pershagen G., Lambert B. Influence of smoking and donor age on the spectrum of in vivo mutation at the HPRT-locus in T lymphocytes of healthy adults. Mutat. Res. 431:1999;325-339.
19. Albertini R.J., Castle K.L., Borcherding W.R. T-cell cloning to detect the mutant 6-thioguanine resistant lymphocytes present in human peripheral blood. Proc. Natl. Acad. Sci. U. S. A. 79:1982;6617-6621.
20. Hou S.-M., Fält S., Steen A.-M. HPRT mutant frequency and GSTM1 genotype in non-smoking healthy individuals. Environ. Mol. Mutagen. 25:1995;97-105.
21. Boer J.G.d., Curry J.D., Glickman B.W. A fast and simple method to determine the clonal relationship among human T-lymphocytes. Mutat. Res. 288:1993;173-180.
22. Bourguin A.R., Tung R., Galili N., Sklar J. Rapid, nonradioactive detection of clonal T-cell receptor gene rearrangements in lymphoid neoplasms. Proc. Natl. Acad. Sci. U. S. A. 87:1990;8536-8540.
23. Bastlova T., Podlutsky A. Molecular analysis of styrene oxide-induced hprt mutation in human T-lymphocytes. Mutagenesis. 11:1996;581-591.
24. Österholm A.-M., Fält S., Lambert B., Hou S.-M. Classification of mutations at the human hprt-locus in T-lymphocytes of bus maintenance workers by multiplex-PCR and reverse transcriptase-PCR analysis. Carcinogenesis. 16:1995;1909-1912.
25. Cariello N.F. Software for the analysis of mutations at the human hprt gene (Release 6 of the human HPRT mutation database. Mutat. Res. 312:1994;173-185. August 1996, Mutabase Software Durham, NC.
26. O'Neill J.P., Hunter T.C., Sullivan L.M., Nicklas J.A., Albertini R.J. Southern-blot analyses of human T-lymphocyte mutants induced in vitro by g-irradiation. Mutat. Res. 240:1990;143-149.
27. Andersson B., Lambert B. Mutations induced by benzo[a]pyrene diolepoxide at the hprt locus in human T-lymphocytes in vitro. Mutat. Res. 245:1990;75-82.
28. Pluth J.M., O'Neill J.P., Nicklas J.A., Albertini R.J. Molecular bases of hprt mutations in malathion-treated human T-lymphocytes. Mutat. Res. 397:1998;137-148.
29. Wang D., Kreutzer D.A., Essigman J.M. Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions. Mutat. Res. 400:1998;99-115.
30. Reid T.M., Loeb L.A. Tandem double CC→TT mutations are produced by reactive oxygen species. Proc. Natl. Acad. Sci. U. S. A. 1993.