Disposition of human recombinant lubricin in naive rats and in a rat model of post-traumatic arthritis after intra-articular or intravenous administration

AAPS Journal

Volumn 14, Issue 1, 2012, Pages 97-104

  Vugmeyster, Yulia ^a   Wang, Qin ^a,b   Xu, Xin ^a,c   Harrold, John ^a   Daugusta, Daren ^a   Li, Jian ^a   Zollner, Richard ^a   Flannery, Carl R ^a   Rivera Bermúdez, Moisés A ^a  

^a PFIZER INC   (United States)

^b Biogenidec ^*  (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

lubricin; osteoarthritis; pharmacokinetics

Indexed keywords

IODINE 125; RECOMBINANT LUBRICIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DISTRIBUTION VOLUME; DOSE RESPONSE; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG RETENTION; DRUG TARGETING; DRUG TISSUE LEVEL; FEMALE; ISOTOPE LABELING; KNEE MENISCUS RUPTURE; LIGAND BINDING; MALE; MICRO AUTORADIOGRAPHY; NONHUMAN; POSTTRAUMATIC ARTHROPATHY; RAT; SINGLE DRUG DOSE; SYSTEMIC CIRCULATION;

ANIMALS; ARTHRITIS, EXPERIMENTAL; AUTORADIOGRAPHY; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; GLYCOPROTEINS; HALF-LIFE; HUMANS; INJECTIONS, INTRA-ARTICULAR; INJECTIONS, INTRAVENOUS; KNEE JOINT; MALE; RATS; RATS, INBRED LEW; RECOMBINANT PROTEINS; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 84857626866     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-011-9315-4     Document Type: Article

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