The negative feedback-loop between the Oncomir mir-24-1 and Menin modulates the men1 tumorigenesis by mimicking the "Knudson's second hit"

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Luzi, Ettore ^a   Marini, Francesca ^a   Giusti, Francesca ^a   Galli, Gianna ^a   Cavalli, Loredana ^a   Brandi, Maria Luisa ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MENIN PROTEIN; MESSENGER RNA; MICRORNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CARCINOGENESIS; COMPUTER MODEL; COMPUTER PREDICTION; COMPUTER PROGRAM; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MEN1 GENE; MULTIPLE ENDOCRINE NEOPLASIA; NEGATIVE FEEDBACK; PARATHYROID ADENOMA; TUMOR SUPPRESSOR GENE;

3' UNTRANSLATED REGIONS; ADENOMA; CELL TRANSFORMATION, NEOPLASTIC; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION PROFILING; LOSS OF HETEROZYGOSITY; MICRORNAS; PARATHYROID NEOPLASMS; PROTO-ONCOGENE PROTEINS;

EID: 84862983916     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039767     Document Type: Article

References (33)

1. Flynt A-S, Lai E-C, (2008) Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nat Rev Genet 9: 831-842.
2. Saini H-K, Griffiths-Jones S, Enright A-J, (2007) Genomic analysis of human microRNA transcripts. Proc Natl Acad Sci USA 104: 17719-17724.
3. Michael M-Z, O' Connor S-M, van Holst Pellekaan N-G, Young G-P, James R-J, (2003) Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res 1: 882-891.
4. Calin G-A, Liu CG, Sevignani C, Ferracin M, Felli N, et al. (2004) MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci USA 101: 11755-11760.
5. Calin G-A, Ferracin M, Cimmino A, Di Leva G, Shimizu M, et al. (2005) A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukaemia. N Engl J Med 353: 1793-1801.
6. Eis P-S, Tam W, Sun L, Chadburn A, Li Z, Gomez MF, et al. (2005) Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci USA 102: 3627-3632.
7. Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, et al. (2004) Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 64: 3753-3756.
8. Iorio M-V, Ferracin M, Liu CG, Veronese A, Spizzo R, et al. (2005) MicroRNA gene expression deregulation in human breast cancer. Cancer Res 65: 7065-7070.
9. Ciafre S-A, Galardi S, Mangiola A, Ferracin M, Liu CG, et al. (2005) Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun 334: 1351-1358.
10. Chan J-A, Krichevsky A-M, Kosik K-S, (2005) MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65: 6029-6033.
11. Calin G-A, Sevignani C, Dumitru CD, Hyslop T, Noch E, et al. (2004) Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 101: 2999-3004.
12. Falchetti A, Marini F, Luzi E, Giusti F, Cavalli L, Cavalli T, et al. (2009) Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors. Genet Med 11: 825-835.
13. Luzi E, Marini F, Tognarini I, Carbonell Sala S, Galli G, et al. (2010) Ribozyme-mediated compensatory induction of menin-oncosuppressor function in primary fibroblasts from MEN1 patients. Cancer Gene Ther 2010 17: 814-825.
14. Keene J-D, (2010) Minireview: global regulation and dynamics of ribonucleic acid. Endocrinology 151: 1391-7.
15. Agarwal S-K, Impey S, McWeeney S, Scacheri PC, Collins FS, et al. (2007) Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation. Neoplasia 9: 101-107.
16. Herranz H, Cohen S-M, (2010) MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev 24: 1339-1344.
17. Petrocca F, Visone R, Onelli MR, Shah MH, Nicoloso MS, et al. (2008) E2F1-regulated microRNAs impair TGFβ-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 13: 272-286.
18. Yang X, Feng M, Jiang X, Wu Z, Li Z, et al. (2009) miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev 23: 2388-2393.
19. Xu N, Papagiannakopoulos T, Pan G, Thomson J-A, Kosik K-S, (2009) MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 137: 647-658.
20. Anlauf M, Perren A, Kloppel G, (2007) Endocrine precursor lesions and microadenomas of the duodenum and pancreas with and without MEN1: criteria, molecular concepts and clinical significance. Pathobiology 74: 279-284.
21. Knudson A-G, (2001) Two genetic hits (more or less) to cancer. Nat Rev Cancer 1: 157-162.
22. Knudson A-G, (1996) Hereditary cancer: two hits revisited. J Cancer Res Clin Oncol 122: 135-140.
23. Knudson A-G, (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68: 820-823.
24. Soto A-M, Sonnenschein C, (2004) The somatic mutation theory of cancer: growing problems with the paradigm? Bioessays 26: 1097-1107.
25. Sonnenschein C, Soto A-M, (2009) Somatic mutation theory of carcinogenesis: why it should be dropped and replaced. Mol Carcinog 29: 205-211.
26. Veitia R-A, (2002) Exploring the etiology of haploinsufficiency. Bioessays 24: 175-184.
27. Ogino S, Wilson R-B, Gold B, Flodman P, (2007) Bayesian risk assessment in genetic testing for autosomal dominant disorders with age-dependent penetrance. J Genet Couns 16: 29-39.
28. Milo R, Shen-Orr S, Itzkovitz S, Kashtan N, Chklovskii D, et al. (2002) Network motifs: Simple building blocks of complex networks. Science 298: 824-827.
29. Martinez N-J, Walhout A-J, (2009) The interplay between transcription factors and microRNAs in genome-scale regulatory networks. Bioessays 31: 435-445.
30. Brandman O, Ferrell J-E, Li R, Meyer T, (2005) Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science 310: 496-498.
31. Hornung G, Barkai N, (2008) Noise propagation and signaling sensitivity in biological networks: a role for positive feedback. PLoS Comput Biol 4: e8.
32. Dublanche Y, Michalodimitrakis K, Kümmerer N, Foglierini M, Serrano L, (2006) Noise in transcription negative feedback loops: simulation and experimental analysis. Mol Syst Biol 2: 41.
33. Galasso M, Elena Sana M, Volinia S, (2010) Non-coding RNAs: a key to future personalized molecular therapy? Genome Med 2: 1.