Translocation of cellular prion protein to non-lipid rafts protects human prion-mediated neuronal damage

International Journal of Molecular Medicine

Volumn 29, Issue 3, 2012, Pages 387-392

  Jeong, Jae Kyo ^a   Moon, Myung Hee ^a   Lee, You Jin ^a   Seol, Jae Won ^a   Park, Sang Youel ^a  

^a Chonbuk National University   (South Korea)

Author keywords

Lipid rafts; Membrane cholesterol enrichment; Neurotoxicity; PrP(106 126)

Indexed keywords

CASPASE 3; CHOLESTEROL; CYTOCHROME C; PRION PROTEIN; PROTEIN BAX; SYNAPTOPHYSIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIPID RAFT; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL LESION; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN TRANSPORT;

APOPTOSIS; CELL LINE, TUMOR; CELL MEMBRANE; CHOLESTEROL; HUMANS; MITOCHONDRIA; NEURONS; PEPTIDE FRAGMENTS; PRIONS; PROTEIN TRANSPORT; PRPC PROTEINS; SIGNAL TRANSDUCTION;

EID: 84862953442     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.864     Document Type: Article

References (31)

1. Brandner S, Klein MA, Frigg R, et al: Neuroinvasion of prions: insights from mouse models. Exp Physiol 85: 705-712, 2000.
2. Kretzschmar HA: Molecular pathogenesis of prion diseases. Eur Arch Psychiatry Clin Neurosci 249 (Suppl 3): S56-S63, 1999.
3. Avrahami D and Gabizon R: Age-related alterations affect the susceptibility of mice to prion infection. Neurobiol Aging 32: 2006-2015, 2009.
4. Diez M, Groth D, DeArmond SJ, Prusiner SB and Hokfelt T: Changes in neuropeptide expression in mice infected with prions. Neurobiol Aging 28: 748-765, 2007. (Pubitemid 46349345)
5. Bate C, Tayebi M and Williams A: The glycosylphosphatidylinositol anchor is a major determinant of prion binding and replication. Biochem J 428: 95-101, 2010.
6. Tomasi V: Signal transduction in neurons: effects of cellular prion protein on fyn kinase and ERK1/2 kinase. Immun Ageing 7 (Suppl 1): S5, 2010.
7. Lewis V and Hooper NM: The role of lipid rafts in prion protein biology. Front Biosci 16: 151-168, 2011.
8. Bate C and Williams A: Monoacylated cellular prion protein modifies cell membranes, inhibits cell signaling, and reduces prion formation. J Biol Chem 286: 8752-8758, 2011.
9. Radford HE and Mallucci GR: The role of GPI-anchored PrP C in mediating the neurotoxic effect of scrapie prions in neurons. Curr Issues Mol Biol 12: 119-127, 2010.
10. Pietri M, Caprini A, Mouillet-Richard S, et al: Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells. J Biol Chem 281: 28470-28479, 2006. (Pubitemid 44414560)
11. Bourteele S, Oesterle K, Weinzierl AO, et al: Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein. Cell Microbiol 9: 2202-2217, 2007. (Pubitemid 47250292)
12. Park JH, Kim BH, Park SJ, et al: Association of endothelial nitric oxide synthase and mitochondrial dysfunction in the hippocampus of scrapie-infected mice. Hippocampus 21: 319-333, 2011.
13. Gu Y, Fujioka H, Mishra RS, Li R and Singh N: Prion peptide 106-126 modulates the aggregation of cellular prion protein and induces the synthesis of potentially neurotoxic transmembrane PrP. J Biol Chem 277: 2275-2286, 2002. (Pubitemid 34968815)
14. Forloni G, Angeretti N, Chiesa R, et al: Neurotoxicity of a prion protein fragment. Nature 362: 543-546, 1993. (Pubitemid 23113029)
15. Singh N, Gu Y, Bose S, Kalepu S, Mishra RS and Verghese S: Prion peptide 106-126 as a model for prion replication and neurotoxicity. Front Biosci 7: a60-a71, 2002.
16. Stefani M and Liguri G: Cholesterol in Alzheimer's disease: unresolved questions. Curr Alzheimer Res 6: 15-29, 2009.
17. Jeong JK, Seol JW, Moon MH, et al: Cellular cholesterol enrichment prevents prion peptide-induced neuron cell damages. Biochem Biophys Res Commun 401: 516-520, 2010.
18. Kempster S, Bate C and Williams A: Simvastatin treatment prolongs the survival of scrapie-infected mice. Neuroreport 18: 479-482, 2007. (Pubitemid 46668038)
19. Pensalfini A, Zampagni M, Liguri G, et al: Membrane cholesterol enrichment prevents Abeta-induced oxidative stress in Alzheimer's fibroblasts. Neurobiol Aging 32: 210-222, 2011.
20. Bate C, Rumbold L and Williams A: Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. J Neuroinflammation 4: 5, 2007.
21. Tong XK, Nicolakakis N, Fernandes P, et al: Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice. Neurobiol Dis 35: 406-414, 2009.
22. Fonseca AC, Proenca T, Resende R, Oliveira CR and Pereira CM: Neuroprotective effects of statins in an in vitro model of Alzheimer's disease. J Alzheimers Dis 17: 503-517, 2009.
23. Vuletic S, Riekse RG, Marcovina SM, Peskind ER, Hazzard WR and Albers JJ: Statins of different brain penetrability differentially affect CSF PLTP activity. Dement Geriatr Cogn Disord 22: 392-398, 2006. (Pubitemid 44726008)
24. Vargas T, Ugalde C, Spuch C, et al: Aβ accumulation in choroid plexus is associated with mitochondrial-induced apoptosis. Neurobiol Aging 31: 1569-1581, 2010.
25. Imam SZ, Karahalil B, Hogue BA, Souza-Pinto NC and Bohr VA: Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol Aging 27: 1129-1136, 2006. (Pubitemid 43850641)
26. Kannan M, Steinert JR, Forsythe ID, Smith AG and Chernova T: Mevastatin accelerates loss of synaptic proteins and neurite degeneration in aging cortical neurons in a heme-independent manner. Neurobiol Aging 31: 1543-1553, 2010.
27. Hering H, Lin CC and Sheng M: Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability. J Neurosci 23: 3262-3271, 2003. (Pubitemid 36531967)
28. Taghibiglou C, Bradley CA, Gaertner T, Li Y, Wang Y and Wang YT: Mechanisms involved in cholesterol-induced neuronal insulin resistance. Neuropharmacology 57: 268-276, 2009.
29. Bizat N, Peyrin JM, Haik S, et al: Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans. J Neurosci 30: 5394-5403, 2010.
30. Didonna A and Legname G: Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells. Mol Neurodegener 5: 29, 2010.
31. Crews L and Masliah E: Molecular mechanisms of neurodegeneration in Alzheimer's disease. Hum Mol Genet 19: R12-R20, 2010.