Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells

Molecular Neurodegeneration

Volumn 5, Issue 1, 2010, Pages

  Didonna, Alessandro ^a   Legname, Giuseppe ^a,b,c  

^a SISSA   (Italy)

^b SINCROTRONE TRIESTE   (Italy)

^c ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; MEPACRINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL LINE; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; MOUSE; NERVE DEGENERATION; NONHUMAN; PRION DISEASE; SCRAPIE;

ANIMALIA; BOVINAE;

EID: 77955296897     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-5-29     Document Type: Article

References (45)

1. Novel proteinaceous infectious particles cause scrapie. SB Prusiner, Science 1982 216 136 144 10.1126/science.6801762 6801762
2. Prions. SB Prusiner, Proc Natl Acad Sci USA 1998 95 13363 13383 10.1073/pnas.95.23.13363 9811807
3. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. H Bueler M Fischer Y Lang H Bluethmann HP Lipp SJ DeArmond SB Prusiner M Aguet C Weissmann, Nature 1992 356 577 582 10.1038/356577a0 1373228
4. The cellular prion protein binds copper in vivo. DR Brown K Qin JW Herms A Madlung J Manson R Strome PE Fraser T Kruck A von Bohlen W Schulz-Schaeffer, et al. Nature 1997 390 684 687 10.1038/37733 9414160
5. Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. G Schmitt-Ulms G Legname MA Baldwin HL Ball N Bradon PJ Bosque KL Crossin GM Edelman SJ DeArmond FE Cohen SB Prusiner, J Mol Biol 2001 314 1209 1225 10.1006/jmbi.2000.5183 11743735
6. Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor. C Hundt JM Peyrin S Haik S Gauczynski C Leucht R Rieger ML Riley JP Deslys D Dormont CI Lasmezas S Weiss, EMBO J 2001 20 5876 5886 10.1093/emboj/20.21.5876 11689428
7. Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro. J Kanaani SB Prusiner J Diacovo S Baekkeskov G Legname, J Neurochem 2005 95 1373 1386 10.1111/j.1471-4159.2005.03469.x 16313516
8. [Transmissible spongiform encephalopathies in humans]. C Rogivue J Gottwein A Aguzzi M Glatzel, Schweiz Arch Tierheilkd 2002 144 685 690 10.1024/0036-7281.144.12.685 12585209
9. Interaction of cellular prion and stress-inducible protein 1 promotes neuritogenesis and neuroprotection by distinct signaling pathways. MH Lopes GN Hajj AG Muras GL Mancini RM Castro KC Ribeiro RR Brentani R Linden VR Martins, J Neurosci 2005 25 11330 11339 10.1523/JNEUROSCI.2313-05.2005 16339028
10. Cellular prion protein transduces neuroprotective signals. LB Chiarini AR Freitas SM Zanata RR Brentani VR Martins R Linden, EMBO J 2002 21 3317 3326 10.1093/emboj/cdf324 12093733
11. Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons. M Fuhrmann T Bittner G Mitteregger N Haider S Moosmang H Kretzschmar J Herms, J Neurochem 2006 98 1876 1885 10.1111/j.1471-4159.2006. 04011.x 16945105
12. Altered intracellular calcium homeostasis in cerebellar granule cells of prion protein-deficient mice. JW Herms S Korte S Gall I Schneider S Dunker HA Kretzschmar, J Neurochem 2000 75 1487 1492 10.1046/j.1471-4159.2000.0751487.x 10987828
13. Scrapie prions alter receptor-mediated calcium responses in cultured cells. K Kristensson B Feuerstein A Taraboulos WC Hyun SB Prusiner SJ DeArmond, Neurology 1993 43 2335 2341 8232952
14. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. J Lauren DA Gimbel HB Nygaard JW Gilbert SM Strittmatter, Nature 2009 457 1128 1132 10.1038/nature07761 19242475
15. Signal transduction by MAP kinases: regulation by phosphorylation- dependent switches. AJ Whitmarsh RJ Davis, Sci STKE 1999 1999 E1 10.1126/stke.1999.1.pe1 11865181
16. Mammalian MAP kinase signalling cascades. L Chang M Karin, Nature 2001 410 37 40 10.1038/35065000 11242034
17. Signal transduction through prion protein. S Mouillet-Richard M Ermonval C Chebassier JL Laplanche S Lehmann JM Launay O Kellermann, Science 2000 289 1925 1928 10.1126/science.289.5486.1925 10988071
18. Clustering of cellular prion protein induces ERK1/2 and stathmin phosphorylation in GT1-7 neuronal cells. C Monnet J Gavard RM Mege A Sobel, FEBS Lett 2004 576 114 118 10.1016/j.febslet.2004.08.076 15474021
19. Prion protein induced signaling cascades in monocytes. B Krebs C Dorner-Ciossek R Schmalzbauer N Vassallo J Herms HA Kretzschmar, Biochem Biophys Res Commun 2006 340 13 22 10.1016/j.bbrc.2005.11.158 16343423
20. Activation of mitogen-activated protein kinases in hamster brains infected with 263 K scrapie agent. HP Lee YC Jun JK Choi JI Kim RI Carp YS Kim, J Neurochem 2005 95 584 593 10.1111/j.1471-4159.2005.03429.x 16135077
21. Prion-associated increases in Src-family kinases. RR Nixon, J Biol Chem 2005 280 2455 2462 10.1074/jbc.M410883200 15546860
22. Resistance of cell lines to prion toxicity aided by phospho-ERK expression. KM Uppington DR Brown, J Neurochem 2008 105 842 852 10.1111/j.1471-4159.2007.05192.x 18088369
23. Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells. M Pietri A Caprini S Mouillet-Richard E Pradines M Ermonval J Grassi O Kellermann B Schneider, J Biol Chem 2006 281 28470 28479 10.1074/jbc.M602774200 16864581
24. Oxidative stress: free radical production in neural degeneration. ME Gotz G Kunig P Riederer MB Youdim, Pharmacol Ther 1994 63 37 122 10.1016/0163-7258(94)90055-8 7972344
25. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. PL Mellon JJ Windle PC Goldsmith CA Padula JL Roberts RI Weiner, Neuron 1990 5 1 10 10.1016/0896-6273(90)90028-E 2196069
26. Antibodies inhibit prion propagation and clear cell cultures of prion infectivity. D Peretz RA Williamson K Kaneko J Vergara E Leclerc G Schmitt-Ulms IR Mehlhorn G Legname MR Wormald PM Rudd, et al. Nature 2001 412 739 743 10.1038/35089090 11507642
27. Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease. C Korth BC May FE Cohen SB Prusiner, Proc Natl Acad Sci USA 2001 98 9836 9841 10.1073/pnas.161274798 11504948
28. Cell models of prion infection. D Vilette, Vet Res 2008 39 10 10.1051/vetres:2007049 18073097
29. Extracellular-signal-regulated kinase signalling in neurons. SS Grewal RD York PJ Stork, Curr Opin Neurobiol 1999 9 544 553 10.1016/S0959-4388(99)00010-0 10508738
30. Differential roles of ERK and JNK in early and late stages of neuritogenesis: a study in a novel PC12 model system. J Xiao Y Liu, J Neurochem 2003 86 1516 1523 10.1046/j.1471-4159.2003.01961.x 12950460
31. The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prion-infected cells. A Ertmer S Gilch SW Yun E Flechsig B Klebl M Stein-Gerlach MA Klein HM Schatzl, J Biol Chem 2004 279 41918 41927 10.1074/jbc.M405652200 15247213
32. The tyrosine kinase inhibitor imatinib mesylate delays prion neuroinvasion by inhibiting prion propagation in the periphery. SW Yun A Ertmer E Flechsig S Gilch P Riederer M Gerlach HM Schatzl MA Klein, J Neurovirol 2007 13 328 337 10.1080/13550280701361516 17849316
33. Inhibitors of the mitogen-activated protein kinase kinase 1/2 signaling pathway clear prion-infected cells from PrPSc. EK Nordstrom KM Luhr C Ibanez K Kristensson, J Neurosci 2005 25 8451 8456 10.1523/JNEUROSCI.2349-05.2005 16162927
34. Src in synaptic transmission and plasticity. LV Kalia JR Gingrich MW Salter, Oncogene 2004 23 8007 8016 10.1038/sj.onc.1208158 15489918
35. Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases. JH Zhu SM Kulich TD Oury CT Chu, Am J Pathol 2002 161 2087 2098 12466125
36. Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain. C Russo V Dolcini S Salis V Venezia N Zambrano T Russo G Schettini, J Biol Chem 2002 277 35282 35288 10.1074/jbc.M110785200 12084708
37. Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. KT Dineley M Westerman D Bui K Bell KH Ashe JD Sweatt, J Neurosci 2001 21 4125 4133 11404397
38. Chronic activation of ERK and neurodegenerative diseases. L Colucci-D'Amato C Perrone-Capano U di Porzio, Bioessays 2003 25 1085 1095 10.1002/bies.10355 14579249
39. Overexpression of nonconvertible PrPc delta114-121 in scrapie-infected mouse neuroblastoma cells leads to trans-dominant inhibition of wild-type PrP(Sc) accumulation. C Holscher H Delius A Burkle, J Virol 1998 72 1153 1159 9445012
40. Opposing effects of ERK and p38-JNK MAP kinase pathways on formation of prions in GT1-1 cells. E Nordstrom G Fisone K Kristensson, Faseb J 2009 23 613 622 10.1096/fj.08-115360 18824519
41. A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis. HM Schätzl L Laszlo DM Holtzman J Tatzelt SJ DeArmond RI Weiner WC Mobley SB Prusiner, J Virol 1997 71 8821 8831 9343242
42. Mapping the prion protein using recombinant antibodies. RA Williamson D Peretz C Pinilla H Ball RB Bastidas R Rozenshteyn RA Houghten SB Prusiner DR Burton, J Virol 1998 72 9413 9418 9765500
43. Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. M Vogtherr S Grimme B Elshorst DM Jacobs K Fiebig C Griesinger R Zahn, J Med Chem 2003 46 3563 3564 10.1021/jm034093h 12904059
44. Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds. PW Phuan JA Zorn J Safar K Giles SB Prusiner FE Cohen BC May, J Gen Virol 2007 88 1392 1401 10.1099/vir.0.82601-0 17374787
45. Evaluation of quinacrine treatment for prion diseases. A Barret F Tagliavini G Forloni C Bate M Salmona L Colombo A De Luigi L Limido S Suardi G Rossi, et al. J Virol 2003 77 8462 8469 10.1128/JVI.77.15.8462-8469.2003 12857915