Impact of high-fat and high-carbohydrate diets on liver metabolism studied in a rat model with a systems biology approach

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 2, 2012, Pages 676-684

  Bertram, Hanne Christine ^a   Larsen, Lotte Bach ^a   Chen, Xiaoping ^b,c   Jeppesen, Per Bendix ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

Author keywords

betaine; hepatic metabolism; metabolic syndrome; metabonomics; protein expression; proteomics

Indexed keywords

BETAINE; METABOLIC SYNDROMES; METABONOMICS; PROTEIN EXPRESSION; PROTEOMICS;

CARBOHYDRATES; GLUCOSE; METABOLISM; MOLECULAR BIOLOGY; NUCLEAR MAGNETIC RESONANCE; PHYSIOLOGY; PROTEINS; RATS;

NUTRITION;

CARBOHYDRATE; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; LACTIC ACID DERIVATIVE; MALATE DEHYDROGENASE; PROTEIN;

ANIMAL; ARTICLE; BODY WEIGHT; DIET; DRUG EFFECT; EATING; LIPID DIET; LIVER; MALE; METABOLISM; METABOLOMICS; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEOMICS; RAT; WISTAR RAT;

ANIMALS; BODY WEIGHT; CARBOHYDRATES; DIET; DIET, HIGH-FAT; EATING; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; LACTATES; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALATE DEHYDROGENASE; MALE; METABOLOMICS; PROTEINS; PROTEOMICS; RATS; RATS, WISTAR;

RATTUS;

EID: 84862929597     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf203994k     Document Type: Article

References (44)

1. Bertram, H. C.; Bach Knudsen, K. E.; Serena, A.; Malmendal, A.; Nielsen, N. C.; Fretté, X. C.; Andersen, H. J. NMR-based metabonomic studies reveal changes in the biochemical profile of plasma and urine from pigs fed high-fibre rye bread Br. J. Nutr. 2006, 95, 955-962 (Pubitemid 43805383)
2. Bertram, H. C.; Hoppe, C.; Petersen, B. O.; Duus, J. O.; Mølgaard, C.; Michaelsen, K. F. An NMR-based metabonomic investigation on effects of milk and meat protein diets given to 8-year-old boys Br. J. Nutr. 2007, 97, 758-763 (Pubitemid 46470685)
3. Yang, H. P.; Pang, W.; Lu, H.; Cheng, D. M.; Yan, X. Z.; Cheng, Y. Y.; Jiang, Y. G. Comparison of metabolic profiling of cyanidin-3- O -galactoside and extracts from blueberry in aged mice J. Agric. Food Chem. 2011, 59, 2069-2076
4. Daykin, C. A.; Van Duynhoven, J. P. M.; Groenewegen, A.; Dachtler, M.; Van Amelsvoort, J. M. M.; Mulder, T. P. J. Nuclear magnetic resonance spectroscopic based studies of the metabolism of black tea polyphenols in humans J. Agric. Food Chem. 2005, 53, 1428-1434 (Pubitemid 40322130)
5. Bertram, H. C.; Jeppesen, P. B.; Hermansen, K. An NMR-based metabonomic investigation on effects of supplementation with isosteviol or soy protein to diabetic KKAy mice Diabetes, Obes. Metab. 2009, 11, 992-995
6. Wang, Y. L.; Tang, H. R.; Nicholson, J. K.; Hylands, P. J.; Sampson, J.; Holmes, E. A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) J. Agric. Food Chem. 2005, 53, 191-196 (Pubitemid 40129901)
7. Lankinen, M.; Schwab, U.; Gopalacharyulu, P. V.; Seppanen-Laakso, T.; Yetukuri, L.; Sysi-Aho, M.; Kallio, P.; Suortti, T.; Laaksonen, D. E.; Gylling, H.; Poutanen, K.; Kolehmainen, M.; Oresic, M. Dietary carbohydrate modification alters serum metabolic profiles in individuals with the metabolic syndrome Nutr. Metab. Cardiovasc. Dis. 2010, 20, 249-257
8. Bertram, H. C.; Malmendal, A.; Nielsen, N. C.; Straadt, I. K.; Larsen, T.; Bach Knudsen, K. E.; Lærke, H. N. NMR-based metabonomics reveals that plasma betaine increases upon intake of high-fiber rye buns in hypercholesterolemic pigs Mol. Nutr. Food Res. 2009, 53, 1055-1062
9. Zhang, Q.; Wang, G. J.; Jiye, A.; Ma, B.; Dua, Y.; Zhu, L. L.; Wu, D. Metabonomic profiling of diet-induced hyperlipidaemia in a rat model Biomarkers 2010, 15, 205-216
10. Peters, S.; Janssen, H. G.; Vivo-Truyols, G. Trend analysis of time-series data: a novel method for untargeted metabolite discovery Anal. Chim. Acta 2010, 663, 98-104
11. 1H NMR-based metabonomic analysis Nutrients 2010, 2, 1141-1155
12. Heinzmann, S. S.; Brown, I. J.; Chan, Q.; Bictash, M.; Dumas, M. E.; Kochhar, S.; Stamler, J.; Holmes, E.; Elliott, P.; Nicholson, J K. Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption Am. J. Clin. Nutr. 2010, 92, 436-443
13. Stefan, N.; Kantartzis, K.; Häring, H.-U. Causes and metabolic consequences of fatty liver Endocrine Rev. 2008, 29, 939-960
14. 1H NMR spectroscopic study Anal. Chem. 2007, 79, 168-175 (Pubitemid 46095043)
15. Serkova, N. J.; Jackman, M.; Brown, J. L.; Liu, T.; Hirose, R.; Roberts, J. P.; Maher, J. J.; Niemann, C. U. Metabolic profiling of livers and blood from obese Zucker rats J. Hepatol. 2006, 44, 956-962
16. van Ginneken, V.; Verhey, E.; Poelmann, R.; Ramakers, R.; van Dijk, K. W.; Ham, L.; Voshol, P.; Havekes, L.; Van Eck, M.; van der Greef, J. Metabolomics (liver and blood profi ling) in a mouse model in response to fasting: a study of hepatic steatosis Biochim. Biophys. Acta 2007, 1771, 1263-1270 (Pubitemid 47500220)
17. Gu, S. H.; Jiye, A.; Wang, G. J.; Zha, W. B.; Yan, B.; Zhang, Y.; Ren, H. C.; Cao, B.; Liu, L. S. Metabonomic profiling of liver metabolites by gas chromatography-mass spectrometry and its application to characterizing hyperlipidemia Biomed. Chromatogr. 2010, 24, 245-252
18. Vinaixa, M.; Rodriguez, M. A.; Rull, A.; Beltran, R.; Blade, C.; Brezmes, J.; Canellas, N.; Joven, J.; Correig, X. Metabolomic assessment of the effect of dietary cholesterol in the progressive development of fatty liver disease J. Proteome Res. 2010, 9, 2527-2538
19. Kim, H.-J.; Kim, J. H.; Noh, S.; Hur, H. J.; Sung, M. J.; Hwang, J.-T.; Park, J. H.; Yang, H. J.; Kim, M.-S.; Kwon, D. Y.; Yoon, S. H. Metabolomic analysis of livers and serum from high-fat diet induced obese mice J. Proteome Res. 2011, 10, 722-731
20. de Roos, B. Proteomic analysis of human plasma and blood cells in nutritional studies: development of biomarkers to aid disease prevention Expert Rev. Proteomics 2008, 5, 819-826
21. Kussmann, M.; Panchaud, A.; Affolter, M. Proteomics in nutrition: status quo and outlook for biomarkers and bioactives J. Proteome Res. 2010, 9, 4876-4887
22. Cruz-Topete, D.; List, E. O.; Okada, S.; Kelder, B.; Kopchick, J. J. Proteomic changes in the heart of diet-induced pre-diabetic mice J. Proteomics 2011, 74, 716-727
23. Young, J.; Larsen, L. B.; Malmendal, A.; Nielsen, N. C.; Straadt, I. K.; Oksbjerg, N.; Bertram, H. C. Creatine-induced activation of antioxidative defence in myotube cultures revealed by explorative NMR-based metabonomics and proteomics J. Int. Soc. Sports Nutr. 2010, 7, 7-9
24. 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-α null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome Physiol. Genomics 2006, 27, 178-186 (Pubitemid 46702031)
25. Kang, D. H.; Gho, Y. S.; Suh, M. K.; Kang, C. H. Highly sensitive and fast protein detection with coomassie brilliant blue in sodium dodecyl sulfate-polyacrylamide gel electrophoresis Bull. Korean Chem. Soc. 2002, 23, 1511-1512
26. Martens, H.; Martens, M. Modified jack-knife estimation of parameter uncertainty in bilinear modelling by partial least squares regression (PLSR) Food Qual. Pref. 2000, 11, 5-16
27. Lindon, J. C.; Nicholson, J. K.; Everett, J. R. NMR spectroscopy of biofluids Annu. Rep. NMR Spectrosc. 1999, 38, 1-88
28. Wishart, D. S.; Knox, C.; Guo, A. C.; Eisner, R.; Young, N.; Gautam, B.; Hau, D. D.; Psychogios, N.; Dong, E.; Boutra, S.; Mandal, R.; Sinelnikov, I.; Xia, J.; Jia, L.; Cruz, J. A.; Lim, E.; Sobsey, C. A.; Shrivastava, S.; Huang, P.; Liu, P.; Fang, L.; Peng, J.; Fradette, R.; Cheng, D.; Tzur, D.; Clements, M.; Lewis, A.; De Souza, A.; Zuniga, A.; Dawe, M.; Xiong, Y.; Clive, D.; Greiner, R.; Nazyrova, A.; Shaykhutdinov, R.; Li, L.; Vogel, H. J.; Forsythe, I. HMDB: a knowledgebase for the human metabolome Nucleic Acids Res. 2009, 37 (Suppl. 1) D603-D610
29. Waters, N. J.; Holmes, E.; Waterfield, C. J.; Farrant, R. D.; Nicholson, J. K. NMR and pattern recognition studies on liver extract and intact livers from rats treated with α-naphthylisothiocynate Biochem. Pharmacol. 2002, 64, 67-77 (Pubitemid 34775177)
30. Schaefer, E. J.; Lichtenstein, A. H.; Lamon-Fava, S.; McNamara, J. R.; Schaefer, M. M.; Rasmussen, H.; Ordovas, J. M. Body weight and low-density lipoprotein cholesterol changes after consumption of a low-fat ad libitum diet JAMA, J. Am. Med. Assoc. 1995, 274, 1450-1455
31. Siggaard, R.; Raben, A.; Astrup, A. Weight loss during 12 weeks ad libitum carbohydrate-rich diet in overweight and normal-weight subjects at a Danish work site Obes. Res. 1996, 4, 347-356 (Pubitemid 126690216)
32. Astrup, A.; Grunwald, G. K.; Melanson, E. L.; Saris, W. H.; Hill, J. O. The role of low-fat diets in body weight control: a meta-analysis of ad libitum dietary intervention studies Int. J. Obes. Relat. Metab. Disord. 2000, 24, 1545-1552
33. Kendall, A.; Levitsky, D. A.; Strupp, B. J.; Lissner, L. Weight loss on a low-fat diet: consequence of the imprecision of the control of food intake in humans Am. J. Clin. Nutr. 1991, 53, 1124-1129
34. Lin, L.; Martin, R.; Schaffhauser, A. O.; York, D. A. Acute changes in the response to peripheral leptin with alteration in the diet composition Am. J. Physiol. 2001, 280, R504-R509
35. Van Heek, M.; Compton, D. S.; France, C. F.; Tedesco, R. P.; Fawzi, A. B.; Graziano, M. P.; Sybertz, E. J.; Strader, C. D.; Davis, H. R., Jr. Diet-induced obese mice develop peripheral, but not central, resistance to leptin J. Clin. Invest. 1997, 99, 385-390 (Pubitemid 27414794)
36. El-Haschimi, K.; Pierroz, D. D.; Hileman, S. M.; Bjorbaek, C.; Flier, J. S. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity J. Clin. Invest. 2000, 105, 1827-1832 (Pubitemid 30421764)
37. Widdowson, P. S.; Upton, R.; Buckingham, R.; Arch, J.; Williams, G. Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity Diabetes 1997, 46, 1782-1785 (Pubitemid 27456411)
38. Havel, P. J.; Townsend, R.; Chaump, L.; Teff, K. High-fat meals reduce 24-h circulating leptin concentrations in women Diabetes 1999, 48, 334-341 (Pubitemid 29061107)
39. Wang, H.; Tan, H.; Yang, F. Mechanisms in homocysteine-induced vascular disease Drug Discovery Today 2005, 2, 25-31
40. Schwarz, J. M.; Neese, R. A.; Turner, S.; Dare, D.; Hellerstein, M. K. Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, liplysis, and whole-body fuel selection J. Clin. Invest. 1995, 96, 2735-2743
41. Bisschop, P. H.; Pereira Arias, A. M.; Ackermans, M. T.; Endert, E.; Pijl, H.; Kuipers, F. The effects of carbohydrate variation in isocaloric diet son glycogenolysis and gluconeogenesis in healthy men J. Clin. Endocrinol. Metab. 2000, 85, 1963-1967 (Pubitemid 32269306)
42. Allick, G.; Bisschop, P. H.; Ackermans, M. T.; Endert, E.; Meijer, A. J.; Kuipers, F. A low-carbohydrate/high-fat diet improves glucoregulation in type 2 diabetes mellitus by reducing postabsorptive glycogenolysis J. Clin Endocrinol. Metab. 2004, 89, 6193-6197 (Pubitemid 39628433)
43. Nutall, F. Q.; Ngo, A.; Gannon, M. C. Regulation of hepatic glucose production and the role of gluconeogenesis in humans: is the rate of gluconeogenesis constant? Diabetes Metab. Res. Rev. 2008, 24, 438-468
44. Caperna, T. J.; Shannon, A. E.; Garrett, W. M. A gel-based map of the porcine hepatocyte proteome Domestic Anim. Endocrinol. 2008, 35, 142-156