An NMR-based metabonomic investigation on effects of supplementation with isosteviol or soy protein to diabetic KKAy mice

Diabetes, Obesity and Metabolism

Volumn 11, Issue 10, 2009, Pages 992-995

  Bertram, H C ^a   Jeppesen, P B ^b   Hermansen, K ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ISOFLAVONE; ISOSTEVIOL; SOYBEAN PROTEIN; STEVIOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; INSULIN SENSITIVITY; LIPOPROTEIN BLOOD LEVEL; METABOLOMICS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NOTE; PROTON NUCLEAR MAGNETIC RESONANCE; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; DITERPENES, KAURANE; HYPOGLYCEMIC AGENTS; LIPOPROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOMICS; MICE; MICE, INBRED BALB C; OBESITY; SOYBEAN PROTEINS;

EID: 70349768347     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2009.01077.x     Document Type: Note

References (13)

1. Jeppesen PB, Gregersen S, Rolfsen SE. Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat. Metabolism 2003, 52:372-378.
2. Nordentoft I, Jeppesen PB, Hong J, Abudula R, Hermansen K. Isosteviol increases insulin sensitivity and changes gene expression of key insulin regulatory genes and transcription factors in islets of the diabetic KKAy mouse. Diabetes Obes Metab 2008, 10:939-949.
3. Descovich GC, Ceredi C, Gaddi A. Multicentre study of soybean protein diet for outpatient hyper-cholesterolaemic patients. Lancet 1980, 2:709-712.
4. Anderson RL, Wolf WJ. Compositional changes in trypsin inhibitors, phytic acid, saponins and isoflavones related to soybean processing. J Nutr 1995, 125:581S-588S.
5. Griffin JL, Vidal-Puig A. Current challenges in metabolomics for diabetes research: a vital functional genomic tool or just a ploy for gaining funding?. Physiol Genomics 2008, 34:1-5.
6. Plumb RS, Granger JH, Stumpf CL. A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice. Analyst 2005, 130:844-849.
7. McKee CLG, Wilson ID, Nicholson JK. Metabolic phenotyping of nude and normal (Alpk: ApfCD, C57BL10J) mice. J Proteome Res 2006, 5:378-384.
8. Cloarec O, Dumas ME, Craig A. Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic H-1 NMR data sets. Anal Chem 2005, 77:1282-1289.
9. Shearer J, Duggan G, Weljie A, Hittel DS, Wasserman DH, Vogel HJ. Metabolic profiling of dietary-induced insulin resistance in the high fat-fed C57BL/6J mouse. Diabetes Obes Metab 2008, 10:950-958.
10. Suna T, Salminen A, Soininen P. 1H NMR metabonomics of plasma lipoprotein subclasses: elucidation of metabolic clustering by self-organising maps. NMR Biomed 2007, 20:658-672.
11. Adeli K, Lewis GF. Intestinal lipoprotein overproduction in insulin-resistant states. Curr Opin Lipidol 2007, 19:221-228.
12. Schaefer EJ. Lipoproteins, nutrition, and heart disease. Am J Clin Nutr 2002, 75:191-212.
13. Nordentoft I, Jeppesen PB, Hong R, Abudula R, Hermansen K. Increased insulin sensitivity and changes in the expression profile of key insulin regulatory genes and beta cell transcription factors in diabetic KKAy-mice after feeding with a soy bean protein rich diet high in isoflavone content. J Agric Food Chem 2008, 56:4377-4385.