Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice

Archives of Toxicology

Volumn 86, Issue 4, 2012, Pages 563-569

  Hayashi, Yumi ^a   Ito, Yuki ^a,b   Kamijima, Michihiro ^b   Nakajima, Tamie ^a   Yanagiba, Yukie ^a,c   Naito, Hisao ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c NATIONAL INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH   (Japan)

Author keywords

Cytochrome P450 4A; Di(2 ethylhexyl)phthalate; Lipase; Pregnant; UDP glucuronyl transferase (UGT)

Indexed keywords

CYTOCHROME; CYTOCHROME P450 4A14; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXPOSURE; FEMALE; FETUS (ANATOMY); GESTATION PERIOD; LIVER LEVEL; MALE; METABOLISM; MOUSE; NONHUMAN; PERINATAL PERIOD; PREGNANCY; PRIORITY JOURNAL; PROGENY; PUERPERIUM; PUP (RODENT);

ANIMALS; ANIMALS, NEWBORN; CYTOCHROME P-450 ENZYME SYSTEM; DIETHYLHEXYL PHTHALATE; FEMALE; FETUS; GLUCURONOSYLTRANSFERASE; LIPASE; LIVER; MALE; MICE; MICE, 129 STRAIN; PLASTICIZERS; POSTPARTUM PERIOD; PREGNANCY;

MUS;

EID: 84862906890     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0790-2     Document Type: Article

References (30)

1. Albro PW, Lavenhar SR (1989) Metabolism of di(2-ethylhexyl). phthalate. Drug Metab Rev 21:13-34.
2. AndersonGD(2005) Pregnancy-induced changes in pharmacokinetics:. a mechanistic-based approach. Clin Pharmacokinet 44:989-1008.
3. Dostal LA, Weaver RP, Schwetz BA (1987) Transfer of. di(2-ethylhexyl) phthalate through rat milk and effects on milk. composition and the mammary gland. Toxicol Appl Pharmacol. 91:315-325.
4. Gollamudi R, Rao RH, Lawrence WH, Autian J (1985) Developmental. changes in the conversion rates of di(2-ethylhexyl)phthalate. to monoethylhexyl phthalate in rats. J Toxicol Environ. Health 15:459-465.
5. Hayashi Y, Ito Y, Yamagishi N, Yanagiba Y, Tamada H, Wang D,. Ramdhan DH, Naito H, Harada Y, Kamijima M, Gonzales FJ,. Nakajima T (2011) Hepatic peroxisome proliferator-activated. receptor alpha may have an important role in the toxic effects of. di(2-ethylhexyl)phthalate on offspring of mice. Toxicology. 289:1-10.
6. He XJ, Ejiri N, Nakayama H, Doi K (2005) Effects of pregnancy on. CYPs protein expression in rat liver. Exp Mol Pathol 78:64-70.
7. Ito Y, Yokota H, Wang R, Yamanoshita O, Ichihara G, Wang H,. Kurata Y, Takagi K, Nakajima T (2005) Species differences in. the metabolism of di(2-ethylhexyl)phthalate (DEHP) in several. organs of mice, rats, and marmosets. Arch Toxicol 79:147-154.
8. Ito Y, Yamanoshita O, Kurata Y, Kamijima M, Aoyama T, Nakajima. T (2007) Induction of peroxisome proliferator-activated receptor. alpha (PPARalpha)-related enzymes by di(2-ethylhexyl)phthalate. (DEHP) treatment in mice and rats, but not marmosets. Arch. Toxicol 81:219-226.
9. Japan Plasticizer Industry Association (2010) Statistical data of. production and shipment. http://www.kasozai.gr.jp/data/toukeipdf/. 2011-05seisan.pdf. Accessed 14 Jul 2011.
10. Kavlock R, Barr D, Boekelheide K, Breslin W, Breysse P, Chapin R,. Gaido K, Hodgson E, Marcus M, Shea K, Williams P (2006). NTP-CERHR expert panel update on the reproductive and. developmental toxicity of di(2-ethylhexyl)phthalate. Reprod. Toxicol 22:291-399.
11. Kishi M, Emi Y, Sakaguchi M, Ikushiro S, Iyanagi T (2008) Ontogenic. isoform switching of UDP-glucuronosyltransferase family 1 in. rat liver. Biochem Biophys Res Commun 377:815-819.
12. Kuntzman R, Jacobson M, Schneidman K, Conney AH (1964). Similarities between oxidative drug-metabolizing enzymes and. steroid hydroxylases in liver microsomes. J Pharmacol Exp Ther. 146:280-285.
13. Kuntzman R, Sansur M, Conney AH (1965) Effect of drugs and. insecticides on the anesthetic action of steroids. Endocrinology. 77:952-954.
14. Lamb JCT, Chapin RE, Teague J, Lawton AD, Reel JR (1987). Reproductive effects of four phthalic acid esters in the mouse. Toxicol Appl Pharmacol 88:255-269.
15. Lof M, Hilakivi-Clarke L, Sandin SS, de Assis S, Yu W, Weiderpass. E (2009) Dietary fat intake and gestational weight gain in. relation to estradiol and progesterone plasma levels during. pregnancy: a longitudinal study in Swedish women. BMC. Womens Health 9:10.
16. Luquita MG, Catania VA, Pozzi EJ, Veggi LM, Hoffman T,. Pellegrino JM, Ikushiro S, Emi Y, Iyanagi T, Vore M, Mottino. AD (2001) Molecular basis of perinatal changes in UDPglucuronosyltransferase. activity in maternal rat liver. J Pharmacol. Exp Ther 298:49-56.
17. Maglich JM, Lobe DC, Moore JT (2009) The nuclear receptor CAR. (NR1I3) regulates serum triglyceride levels under conditions of. metabolic stress. J Lipid Res 50:439-445.
18. Maloney EK, Waxman DJ (1999) Trans-activation of PPAR alpha. and PPAR gamma by structurally diverse environmental chemicals. Toxicol Appl Pharmacol 161:209-218.
19. Neale MG, Parke DV (1973) Effects of pregnancy on the metabolism. of drugs in the rat and rabbit. Biochem Pharmacol 22:1451-1461.
20. Pelkonen O (1980) Biotransformation of xenobiotics in the fetus. Pharmacol Ther 10:261-281.
21. Ramdhan DH, Kamijima M, Yamada N, Ito Y, Yanagiba Y,. Nakamura D, Okamura A, Ichihara G, Aoyama T, Gonzalez. FJ, Nakajima T (2008) Molecular mechanism of trichloroethylene-. induced hepatotoxicity mediated by CYP2E1. Toxicol Appl. Pharmacol 231:300-307.
22. Ramdhan DH, Ito Y, Yanagiba Y, Yamagishi N, Hayashi Y, Li C,. Taneda S, Suzuki AK, Watanabe G, Taya K, Kamijima M,. Nakajima T (2009) Nanoparticle-rich diesel exhaust may disrupt. testosterone biosynthesis and metabolism via growth hormone. Toxicol Lett 191:103-108.
23. Singh AR, Lawrence WH, Autian J (1975) Maternal-fetal transfer of. 14C-di-2-ethylhexyl phthalate and 14C-diethyl phthalate in rats. J Pharm Sci 64:1347-1350.
24. Sjoberg P, Bondesson U, Gustafsson J (1988) Metabolism of mono-. (2-ethylhexyl)phthalate in fetal, neonatal and adult rat liver. Biol. Neonate 53:32-38.
25. Suna S, Jitsunari F, Asakawa F, Kitamado T, Ohnishi S, Hirao T,. Fukunaga I (2001) Simplified determination of di(2-ethylhexyl). phthalate (DEHP) and mono(2-ethylhexyl)phthalate. (MEHP) in blood and organs of the rat administered DEHP. Sangyo Eiseigaku Zasshi 43:73-75 (in Japanese).
26. Suzuki Y, Niwa M, Yoshinaga J, Watanabe C, Mizumoto Y, Serizawa. S, Shiraishi H (2009) Exposure assessment of phthalate esters in. Japanese pregnant women by using urinary metabolite analysis. Environ Health Prev Med 14:180-187.
27. Wang RS, Nakajima T, Honma T (1999) Trichloroethylene inhibits. aldehyde dehydrogenase only for aliphatic aldehydes of short. chains in rats. Toxicology 132:9-18.
28. Wang Y, Botolin D, Christian B, Busik J, Xu J, Jump DB (2005). Tissue-specific, nutritional, and developmental regulation of rat. fatty acid elongases. J Lipid Res 46:706-715.
29. Yan X, Calafat A, Lashley S, Smulian J, Ananth C, Barr D, Silva M,. Ledoux T, Hore P, Robson MG (2009) Phthalates biomarker. identification and exposure estimates in a population of pregnant. women. Hum Ecol Risk Assess 15:565-578.
30. Yano T (1993) Sexing of in vitro-fertilized preimplantation mouse embryos by the PCR method. Jpn J Hum Genet 38:277-288