Nanoparticle-rich diesel exhaust may disrupt testosterone biosynthesis and metabolism via growth hormone

Toxicology Letters

Volumn 191, Issue 2-3, 2009, Pages 103-108

  Ramdhan, Doni Hikmat ^a   Ito, Yuki ^a   Yanagiba, Yukie ^a   Yamagishi, Nozomi ^a   Hayashi, Yumi ^a   Li, ChunMei ^b   Taneda, Shinji ^b   Suzuki, Akira K ^b   Watanabe, Gen ^c   Taya, Kazuyoshi ^c   Kamijima, Michihiro ^a   Nakajima, Tamie ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^c Faculty of Agriculture   (Japan)

Author keywords

Growth hormone receptor; Nanoparticle rich diesel exhaust; P450scc; StAR; Testosterone biosynthesis

Indexed keywords

CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450 2C11; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; NANOPARTICLE; SOMATOMEDIN C; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXHAUST GAS; GENE EXPRESSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPRODUCTIVE TOXICITY; TESTIS; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE METABOLISM; TESTOSTERONE SYNTHESIS; TOXICITY TESTING;

AIR POLLUTANTS, OCCUPATIONAL; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; CARRIER PROTEINS; CHOLESTEROL; ENDOCRINE DISRUPTORS; ESTRADIOL; GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR I; MALE; NANOPARTICLES; PARTICLE SIZE; PHOSPHOPROTEINS; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEROID 16-ALPHA-HYDROXYLASE; TESTIS; TESTOSTERONE; VEHICLE EMISSIONS;

RATTUS;

EID: 70449535625     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.08.013     Document Type: Article

References (35)

1. Adams M.L., Meyer E.R., Sewing B.N., and Cicero T.J. Effects of nitric oxide-related agents on rat testicular function. J. Pharmacol. Exp. Ther. 269 (1994) 230-237
2. Argetsinger L.S., and Carter-Su C. Mechanism of signaling by growth hormone receptor. Physiol. Rev. 76 (1996) 1089-1107
3. Badger T.M., Ronis M.J., Lumpkin C.K., Valentine C.R., Shahare M., Irby D., Huang J., Mercado C., Thomas P., and Ingelman-Sundberg M. Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome P450 isozymes of the rat. J. Pharmacol. Exp. Ther. 264 (1993) 438-447
4. Bick T., Amit T., Barkey R.J., Hertz P., Youdim M.B., and Hochberg Z. The interrelationship of growth hormone (GH), liver membrane GH receptor, serum GH-binding protein activity, and insulin-like growth factor I in the male rat. Endocrinology 126 (1990) 1914-1920
5. Chen G.F., Ronis M.J., Thomas P.E., Flint D.J., and Badger T.M. Hormonal regulation of microsomal cytochrome P450 2C11 in rat liver and kidney. J. Pharmacol. Exp. Ther. 283 (1997) 486-1494
6. Cyrys J., Stolzel M., Heinrich J., Kreyling W.G., Menzel N., Wittmaack K., Tuch T., and Wichmann H.E. Elemental composition and sources of fine and ultrafine ambient particles in Erfurt, Germany. Sci. Total Environ. 305 (2003) 143-156
7. De Rosa M., Zarrilli S., Paesano L., Carbone U., Boggia B., Petretta M., Maisto A., Cimmino F., Puca G., Colao A., and Lombardi G. Traffic pollutants affect fertility in men. Hum. Reprod. 18 (2003) 1055-1061
8. Delfino R.J., Sioutas C., and Malik S. Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health. Environ. Health Perspect. 113 (2005) 934-946
9. Donahue C.P., Kosik K.S., and Shors T.J. Growth hormone is produced within the hippocampus where it responds to age, sex, and stress. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 6031-6036
10. Donaldson K., Tran L., Jimenez L.A., Duffin R., Newby D.E., Mills N., MacNee W., and Stone V. Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure. Part. Fibre Toxicol. 2 (2005) 10
11. Folch J., Lees M., and Sloane Stanley G.H. A simple method for the isolation and purification of total lipids from animal lipids. J. Biol. Chem. 226 (1957) 497-509
12. Fujitani Y., Hirano S., Kobayashi S., Tanabe K., Suzuki A.K., Furuyama A., and Kobayashi T. Characterization of dilution conditions for diesel nanoparticle inhalation studies. Inhal. Toxicol. 21 (2009) 200-209
13. Garshick E., Laden F., Hart J.E., Rosner B., Smith T.J., Dockery D.W., and Speizer F.E. Lung cancer in railroad workers exposed to diesel exhaust. Environ. Health Perspect. 112 (2004) 1539-1543
14. Health Effect Institute. Diesel Exhaust: Critical Analysis of Emissions, Exposure, and Health Effects (1995), Health Effects Institute, Cambridge MA
15. Inoue K., Takano H., Yanagisawa R., Sakurai M., Ichinose T., Sadakane K., and Yoshikawa T. Effects of nano particles on antigen-related airway inflammation in mice. Respir. Res. 6 (2005) 106
16. Isaksson O.G., Edén S., and Jansson J.O. Mode of action of pituitary growth hormone on target cells. Annu. Rev. Physiol. 47 (1985) 483-499
17. Kanzaki M., and Morris P.L. Growth hormone regulates steroidogenic acute regulatory protein expression and steroidogenesis in Leydig cell progenitors. Endocrinology 140 (1999) 1681-1686
18. Kittelson D.B. Engines and nanoparticles: a review. J. Aerosol Sci. 29 (1998) 575-588
19. Li C., Taneda S., Watanabe G., Taya K., Fujitani Y., Ito Y., Nakajima T., and Suzuki A.K. Effects of inhaled nanoparticle-rich diesel exhaust on regulation of testicular function in male rats. Inhal. Toxicol. (2009) 803-811
20. Lin T., Wang D., Hu J., and Stocco D.M. Upregulation of human chorionic gonadotrophin-induced steroidogenic acute regulatory protein by insulin-like growth factor-I in rat Leydig cells. Endocrine 8 (1998) 73-78
21. Ministry of the Environment, Government of Japan. Environmental Quality Standards in Japan-Air Quality. http://www.env.go.jp/en/air/aq/aq.html.
22. Payne A.H. Hormonal regulation of cytochrome P450 enzymes, cholesterol side-chain cleavage and 17 alpha-hydroxylase/C17-20 lyase in Leydig cells. Biol. Reprod. 42 (1990) 399-404
23. Payne A.H., and Youngblood G.L. Regulation of expression of steroidogenic enzymes in Leydig cells. Biol. Reprod. 52 (1995) 217-225
24. Payne A.H., and Hales D.B. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr. Rev. 25 (2004) 947-970
25. Shimada A., Kawamura N., Okajima M., Kaewamatawong T., Inoue H., and Morita T. Translocation pathway of the intratracheally instilled ultrafine particles from the lung into the blood circulation in the mouse. Toxicol. Pathol. 34 (2006) 949-957
26. Stocco D.M. StAR protein and the regulation of steroid hormone biosynthesis. Annu. Rev. Physiol. 63 (2001) 193-213
27. Takafuji S., Suzuki S., Koizumi K., Tadokoro K., Miyamoto T., Ikemori R., and Muranaka M. Diesel-exhaust particulates inoculated by the intranasal route have an adjuvant activity for IgE production in mice. J. Allergy Clin. Immunol. 79 (1987) 639-645
28. Tsukue N., Toda N., Tsubone H., Sagai M., Jin W.Z., Watanabe G., Taya K., Birumachi J., and Suzuki A.K. Diesel exhaust (DE) affects the regulation of testicular function in male Fischer 344 rats. J. Toxicol. Environ. Health A 63 (2001) 115-126
29. Valenti S., Cuttica C.M., Giusti M., and Giordano G. Nitric oxide modulates Leydig cell function in vitro: is this a way of communication between the immune and endocrine system in the testis?. Ann. N.Y. Acad. Sci. 876 (1999) 298-300
30. Wang G.M., O'Shaughnessy P.J., Chubb C., Robaire B., and Hardy M.P. Effects of insulin-like growth factor I on steroidogenic enzyme expression levels in mouse Leydig cells. Endocrinology 144 (2003) 5058-5064
31. Watanabe N., and Oonuki Y. Inhalation of diesel engine exhaust affects spermatogenesis in growing male rats. Environ. Health Perspect. 107 (1999) 539-544
32. Waxman D.J., Dannan G.A., and Guengerich F.P. Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes. Biochemistry 24 (1985) 4409-4417
33. Waxman D.J., and O'Connor C. Growth hormone regulation of sex-dependent liver gene expression. Mol. Endocrinol. 20 (2006) 2613-2629
34. West L.A., Horvat R.D., Roess D.A., Barisas B.G., Juengel J.L., and Niswender G.D. Steroidogenic acute regulatory protein and peripheral-type benzodiazepine receptor associate at the mitochondrial membrane. Endocrinology 142 (2001) 502-505
35. Yoshida S., Sagai M., Oshio S., Umeda T., Ihara T., Sugamata M., Sugawara I., and Takeda K. Exposure to diesel exhaust affects the male reproductive system of mice. Int. J. Androl. 22 (1999) 307-315