메뉴 건너뛰기




Volumn 14, Issue 3, 2009, Pages 180-187

Exposure assessment of phthalate esters in Japanese pregnant women by using urinary metabolite analysis

Author keywords

Biomarkers; Daily intake; Intraclass correlation coefficient; Phthalate esters; Urinary metabolites

Indexed keywords

PHTHALIC ACID ESTER; PLASTIC;

EID: 77249101347     PISSN: 1342078X     EISSN: 13474715     Source Type: Journal    
DOI: 10.1007/s12199-009-0078-9     Document Type: Article
Times cited : (82)

References (43)
  • 1
    • 0041304143 scopus 로고    scopus 로고
    • Available at
    • ATSDR (Agency for Toxic Substances and Disease Registry) Toxicological profile for di(2-ehylhexyl) phthalate. Available at: http://www.atsdr.cdc.gov/ toxprofiles/tp9.html, 2002.
    • (2002) Toxicological Profile for di(2-ehylhexyl) Phthalate
  • 2
    • 0005595638 scopus 로고
    • Available at
    • ATSDR (Agency for Toxic Substances and Disease Registry) Toxicological profile for diethyl phthalate. Available at: http://www.atsdr.cdc.gov/ toxprofiles/tp73.html, 1995.
    • (1995) Toxicological Profile for Diethyl Phthalate
  • 3
    • 0042305705 scopus 로고    scopus 로고
    • Available at
    • ATSDR (Agency for Toxic Substances and Disease Registry) Toxicological profile for di-n-butyl phthalate. Available at: http://www.atsdr.cdc.gov/ toxprofiles/tp135.html, 2001.
    • (2001) Toxicological profile for di-n-butyl phthalate
  • 4
    • 37349099580 scopus 로고    scopus 로고
    • Potential adverse effects of phthalic acid esters on human health: A review of recent studies on reproduction
    • Matsumoto M, Koizumi M, Ema M. Potential adverse effects of phthalic acid esters on human health: A review of recent studies on reproduction. Regul Toxicol Pharmacol. 2008;50:37-49.
    • (2008) Regul Toxicol Pharmacol , vol.50 , pp. 37-49
    • Matsumoto, M.1    Koizumi, M.2    Ema, M.3
  • 5
    • 0034523473 scopus 로고    scopus 로고
    • Perinatal exposure to the phthalates DEHP BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat
    • Gray LE Jr, Ostby J, Furr J, Price M, Veeramachaneni DN, Parks L. Perinatal exposure to the phthalates DEHP BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci. 2000;58:350-365
    • (2000) Toxicol Sci , vol.58 , pp. 350-365
    • Gray Jr., L.E.1    Ostby, J.2    Furr, J.3    Price, M.4    Veeramachaneni, D.N.5    Parks, L.6
  • 6
    • 0035025368 scopus 로고    scopus 로고
    • Effects of phthalate esters on the developing reproductive tract of male rats
    • Foster PMD. Effects of phthalate esters on the developing reproductive tract of male rats. Hum Reprod Update. 2001;7:231-235
    • (2001) Hum Reprod Update , vol.7 , pp. 231-235
    • Foster, P.M.D.1
  • 9
    • 32044470078 scopus 로고    scopus 로고
    • Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age
    • Main KM, Mortensen GK, Kaleva MM, Boisen KA, Damgaard IN, Chellakooty M, et al. Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environ Health Perspect. 2006;114:270-276
    • (2006) Environ Health Perspect , vol.114 , pp. 270-276
    • Main, K.M.1    Mortensen, G.K.2    Kaleva, M.M.3    Boisen, K.A.4    Damgaard, I.N.5    Chellakooty, M.6
  • 10
    • 0021823729 scopus 로고
    • Excretion and metabolism of di(2-ethylhexyl)- phthalate in man
    • Schmid P, Schlatter C. Excretion and metabolism of di(2-ethylhexyl)- phthalate in man. Xenobiotica. 1985;15:251-256
    • (1985) Xenobiotica , vol.15 , pp. 251-256
    • Schmid, P.1    Schlatter, C.2
  • 11
    • 0242468336 scopus 로고    scopus 로고
    • Glucuronidation patterns of common urinary and serum monoester phthalate metabolites
    • Silva MJ, Barr DB, Reidy JA, Kato K, Malek NA, Hodge CC, et al. Glucuronidation patterns of common urinary and serum monoester phthalate metabolites. Arch Toxicol. 2003;77:561-567
    • (2003) Arch Toxicol , vol.77 , pp. 561-567
    • Silva, M.J.1    Barr, D.B.2    Reidy, J.A.3    Kato, K.4    Malek, N.A.5    Hodge, C.C.6
  • 12
    • 0034282493 scopus 로고    scopus 로고
    • Quantitative detection of eight phthalate metabolites in human urine using HPLC-MS/MS
    • Blount BC, Milgram KE, Silva MJ, Malek NA, Reidy JA, Needham LL, et al. Quantitative detection of eight phthalate metabolites in human urine using HPLC-MS/MS. Anal Chem. 2000;72:4127-4134
    • (2000) Anal Chem , vol.72 , pp. 4127-4134
    • Blount, B.C.1    Milgram, K.E.2    Silva, M.J.3    Malek, N.A.4    Reidy, J.A.5    Needham, L.L.6
  • 13
    • 0038414556 scopus 로고    scopus 로고
    • Improved quantitative detection of 11 urinary phthalate metabolites in humans using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry
    • Silva MJ, Malek NA, Hodge CC, Reidy JA, Kato K, Barr DB, et al. Improved quantitative detection of 11 urinary phthalate metabolites in humans using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry. J Chromatogr B. 2003;789:393-404.
    • (2003) J Chromatogr B , vol.789 , pp. 393-404
    • Silva, M.J.1    Malek, N.A.2    Hodge, C.C.3    Reidy, J.A.4    Kato, K.5    Barr, D.B.6
  • 14
    • 0037345870 scopus 로고    scopus 로고
    • An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population
    • Koch HM, Drexler H, Angerer J. An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population. Int J Hyg Environ Health. 2003;206:77-83.
    • (2003) Int J Hyg Environ Health , vol.206 , pp. 77-83
    • Koch, H.M.1    Drexler, H.2    Angerer, J.3
  • 15
    • 0042197599 scopus 로고    scopus 로고
    • The Relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay
    • Duty SM, Singh NP, Silva MJ, Barr DB, Brock JW, Ryan L, et al. The Relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay. Environ Health Perspect. 2003;111:1164-1169
    • (2003) Environ Health Perspect , Issue.111 , pp. 1164-1169
    • Duty, S.M.1    Singh, N.P.2    Silva, M.J.3    Barr, D.B.4    Brock, J.W.5    Ryan, L.6
  • 16
    • 1542686315 scopus 로고    scopus 로고
    • Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999- 2000
    • Silva MJ, Barr DB, Reidy JA, Malek NA, Hodge CC, Caudill SP, et al. Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ Health Perspect. 2004;112:331-338
    • (2004) Environ Health Perspect , vol.112 , pp. 331-338
    • Silva, M.J.1    Barr, D.B.2    Reidy, J.A.3    Malek, N.A.4    Hodge, C.C.5    Caudill, S.P.6
  • 17
    • 33746517515 scopus 로고    scopus 로고
    • Estimation of intake level of di(2-ethylhexyl) phthtalate (DEHP) of Japanese pregnant woman based on measurement of concentrations of three urinary metabolites
    • in Japanese
    • Fujimaki K, Yoshinaga J, Watanabe C, Serizawa S, Shiraishi H, Mizumoto Y. Estimation of intake level of di(2-ethylhexyl) phthtalate (DEHP) of Japanese pregnant woman based on measurement of concentrations of three urinary metabolites. Nippoon Eiseigaku Zasshi. 2006;61:340-347 (in Japanese).
    • (2006) Nippoon Eiseigaku Zasshi , vol.61 , pp. 340-347
    • Fujimaki, K.1    Yoshinaga, J.2    Watanabe, C.3    Serizawa, S.4    Shiraishi, H.5    Mizumoto, Y.6
  • 18
    • 0036105250 scopus 로고    scopus 로고
    • Reproducibility of urinary phthalate metabolites in first morning urine samples
    • Hoppin JA, Brock JW, Davis BJ, Baird DD. Reproducibility of urinary phthalate metabolites in first morning urine samples. Environ Health Perspect. 2002;110:515-518
    • (2002) Environ Health Perspect , vol.110 , pp. 515-518
    • Hoppin, J.A.1    Brock, J.W.2    Davis, B.J.3    Baird, D.D.4
  • 19
    • 10944238528 scopus 로고    scopus 로고
    • Temporal variability of urinary phthalate metabolite levels in men of reproductive age
    • Hauser R, Meeker JD, Park S, Silva MJ, Calafat AM. Temporal variability of urinary phthalate metabolite levels in men of reproductive age. Environ Health Perspect. 2004;112:1734-1740
    • (2004) Environ Health Perspect , vol.112 , pp. 1734-1740
    • Hauser, R.1    Meeker, J.D.2    Park, S.3    Silva, M.J.4    Calafat, A.M.5
  • 20
    • 38549160115 scopus 로고    scopus 로고
    • Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States
    • Teitelbaum SL, Britton JA, Calafat AM, Ye X, Silva MJ, Reidy JA, et al. Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environ Res. 2008;106:257-269
    • (2008) Environ Res , vol.106 , pp. 257-269
    • Teitelbaum, S.L.1    Britton, J.A.2    Calafat, A.M.3    Ye, X.4    Silva, M.J.5    Reidy, J.A.6
  • 21
    • 33846321851 scopus 로고    scopus 로고
    • Occurrence and daily variation of phthalate metabolites in the urine of an adult population
    • Fromme H, Bolte G, Koch HM, Anger J, Boehmer S, Drexler H, et al. Occurrence and daily variation of phthalate metabolites in the urine of an adult population. Int J Hyg Environ Health. 2007;210:21-33.
    • (2007) Int J Hyg Environ Health , vol.210 , pp. 21-33
    • Fromme, H.1    Bolte, G.2    Koch, H.M.3    Anger, J.4    Boehmer, S.5    Drexler, H.6
  • 23
    • 0035196987 scopus 로고    scopus 로고
    • A biomarker approach to measuring human dietary exposure to certain phthalate diesters
    • Anderson WA, Castle L, Scotter MJ, Massey RC, Springall C. A biomarker approach to measuring human dietary exposure to certain phthalate diesters. Food Addit Contam. 2001;18:1068-1074
    • (2001) Food Addit Contam , vol.18 , pp. 1068-1074
    • Anderson, W.A.1    Castle, L.2    Scotter, M.J.3    Massey, R.C.4    Springall, C.5
  • 24
    • 22844433529 scopus 로고    scopus 로고
    • New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP
    • Koch HM, Bolt HM, Preuss R, Angerer J. New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP. Arch Toxicol. 2005;79:367-376
    • (2005) Arch Toxicol , vol.79 , pp. 367-376
    • Koch, H.M.1    Bolt, H.M.2    Preuss, R.3    Angerer, J.4
  • 25
    • 33846258744 scopus 로고    scopus 로고
    • Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP
    • Koch HM, Angerer J. Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP. Int J Hyg Environ Health. 2007;210:9-19.
    • (2007) Int J Hyg Environ Health , vol.210 , pp. 9-19
    • Koch, H.M.1    Angerer, J.2
  • 26
    • 0016138240 scopus 로고
    • Identification of the metabolites of simple phthalate diesters in rat urine
    • Albro PW, Moore B. Identification of the metabolites of simple phthalate diesters in rat urine. J Chromatogr. 1974;94:209-218
    • (1974) J Chromatogr , vol.94 , pp. 209-218
    • Albro, P.W.1    Moore, B.2
  • 28
    • 33749661607 scopus 로고    scopus 로고
    • Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to Di-Butylphthalate (DBP) for use in food contact materials
    • European Food Safety Authority (EFSA)
    • European Food Safety Authority (EFSA). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to Di-Butylphthalate (DBP) for use in food contact materials. EFSA J. 2005;242:1-17.
    • (2005) EFSA J , vol.242 , pp. 1-17
  • 29
    • 33749661607 scopus 로고    scopus 로고
    • Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to Bis(2-ethylhexyl) phthalate (DEHP) for use in food contact materials
    • EF SA
    • EF SA. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to Bis(2-ethylhexyl) phthalate (DEHP) for use in food contact materials. EFSA J. 2005;243:1-20.
    • (2005) EFSA J , vol.243 , pp. 1-20
  • 30
    • 33749661607 scopus 로고    scopus 로고
    • Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to Butylbenzylphthalate (BBzP) for use in food contact materials
    • SA EF
    • SA EF. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to Butylbenzylphthalate (BBzP) for use in food contact materials. EFSA J. 2005;241:1-14.
    • (2005) EFSA J , vol.241 , pp. 1-14
  • 31
    • 77249145476 scopus 로고    scopus 로고
    • Japan Ministry of the Environment. Available at (in Japanese)
    • Japan Ministry of the Environment. Environmental risk assessment of chemicals vol.1 Available at: http://www.env.go.jp/chemi/report/h14-05/index. html, 2002 (in Japanese).
    • (2002) Environmental Risk Assessment of Chemicals , vol.1
  • 32
    • 77249165661 scopus 로고    scopus 로고
    • Japan Ministry of the Environment. Available at (in Japanese)
    • Japan Ministry of the Environment. Environmental risk assessment of chemicals vol.3 Available at: http://www.env.go.jp/chemi/report/h16-01/index. html, 2004 (in Japanese).
    • (2004) Environmental Risk Assessment of Chemicals , vol.3
  • 33
    • 77249093636 scopus 로고    scopus 로고
    • Japan Ministry of the Environment. Available at (in Japanese)
    • Japan Ministry of the Environment. Environmental risk assessment of chemicals vol.4 Available at: http://www.env.go.jp/chemi/report/h17-21/index. html, 2005 (in Japanese).
    • (2005) Environmental Risk Assessment of Chemicals , vol.4
  • 35
    • 33745760668 scopus 로고    scopus 로고
    • The Chemical Daily Tokyo: The Chemical Daily Co, Ltd. in Japanese
    • The Chemical Daily. 14504 chemical products. Tokyo: The Chemical Daily Co, Ltd.; 2004. (in Japanese).
    • (2004) 14504 Chemical Products.
  • 36
    • 20544448920 scopus 로고    scopus 로고
    • Urinary phthalate metabolites and biomarkers of reproductive function in young men
    • Jönsson BA, Richthoff J, Rylander L, Giwercman A, Hagmar L. Urinary phthalate metabolites and biomarkers of reproductive function in young men. Epidemiology. 2005;16:487-493
    • (2005) Epidemiology , vol.16 , pp. 487-493
    • Jönsson, B.A.1    Richthoff, J.2    Rylander, L.3    Giwercman, A.4    Hagmar, L.5
  • 37
    • 34447266656 scopus 로고    scopus 로고
    • Quantitative identification of unknown exposure pathways of phthalates based on measuring their metabolites in human urine
    • Itoh H, Toshida K, Masunaga S. Quantitative identification of unknown exposure pathways of phthalates based on measuring their metabolites in human urine. Environ Sci Technol. 2007; 41:4542-4547
    • (2007) Environ Sci Technol , vol.41 , pp. 4542-4547
    • Itoh, H.1    Toshida, K.2    Masunaga, S.3
  • 38
    • 27744538788 scopus 로고    scopus 로고
    • Personal care product use predicts urinary concentrations of some phthalate monoesters
    • Duty SM, Ackerman RM, Calafat AM, Hauser R. Personal care product use predicts urinary concentrations of some phthalate monoesters. Environ Health Perspect. 2005;113:1530-1535
    • (2005) Environ Health Perspect , vol.113 , pp. 1530-1535
    • Duty, S.M.1    Ackerman, R.M.2    Calafat, A.M.3    Hauser, R.4
  • 39
    • 0037809464 scopus 로고    scopus 로고
    • Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan
    • Tsumura Y, Ishimitsu S, Saito I, Sakai H, Tsuchida Y, Tonogai Y. Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan. Food Addit Contam. 2003;20:317-324
    • (2003) Food Addit Contam , vol.20 , pp. 317-324
    • Tsumura, Y.1    Ishimitsu, S.2    Saito, I.3    Sakai, H.4    Tsuchida, Y.5    Tonogai, Y.6
  • 41
    • 33745037694 scopus 로고    scopus 로고
    • Estimated daily phthalate exposures in a population of mothers of male infants exhibiting reduced anogenital distance
    • Marsee K, Woodruff T, Axelrad D, Calafat A, Swan H. Estimated daily phthalate exposures in a population of mothers of male infants exhibiting reduced anogenital distance. Environ Health Perspect. 2006;114:805-809
    • (2006) Environ Health Perspect , vol.114 , pp. 805-809
    • Marsee, K.1    Woodruff, T.2    Axelrad, D.3    Calafat, A.4    Swan, H.5
  • 43
    • 0012550816 scopus 로고    scopus 로고
    • Internal exposure of the general population to DEHP and other phthalates-determination of secondary and primary phthalate monoester metabolites in urine
    • Koch HM, Rossbach B, Drexler H, Angerer J. Internal exposure of the general population to DEHP and other phthalates-determination of secondary and primary phthalate monoester metabolites in urine. Environ Res. 2003;93:177-185
    • (2003) Environ Res , vol.93 , pp. 177-185
    • Koch, H.M.1    Rossbach, B.2    Drexler, H.3    Angerer, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.