Structural and functional differences between mouse mot-1 and mot-2 proteins that differ in two amino acids

Annals of the New York Academy of Sciences

Volumn 1067, Issue 1, 2006, Pages 220-223

  Deocaris, Custer C ^a,b   Yamasaki, Kazuhiko ^a   Kaul, Sunil C ^a   Wadhwa, Renu ^a,b  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Alleles; Chaperones; Differential functions; Heat shock protein 70; Mortalin; Structure

Indexed keywords

AMINO ACID; CHAPERONE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; MITOCHONDRIAL PROTEIN; MORTALIN; PROTEIN MOT 1; PROTEIN MOT 2; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SEQUENCE; ANIMAL CELL; CARCINOGENESIS; CELL IMMORTALIZATION; CONFERENCE PAPER; CONTROLLED STUDY; EMBRYO; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE;

EID: 33744485567     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1354.027     Document Type: Conference Paper

References (8)

1. Wadhwa, R., S.C. Kaul, Y. Ikawa, et al. 1993. Identification of a novel member of mouse hsp70 family: its association with cellular mortal phenotype. J. Biol. Chem. 268: 6615 6621.
2. Wadhwa, R., S.C. Kaul, Y. Sugimoto, et al. 1993. Induction of cellular senescence by transfection of cytosolic mortalin cDNA in NIH 3T3 cells. J. Biol. Chem. 268: 22239 22242.
3. Kaul, S.C., E.L. Duncan, A. Englezou, et al. 1998. Malignant transformation of NIH 3T3 cells by overexpression of mot-2 protein. Oncogene 17: 907 911.
4. Kaul, S.C., R.R. Reddel, T. Sugihara, et al. 2000. Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2. FEBS Lett. 474: 159 164.
5. Yokoyama, K., K. Fukumoto, T. Murakami, et al. 2002. Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. FEBS Lett. 516: 53 57.
6. Wadhwa, R., S. Takano, M. Robert, et al. 1998. Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member. J. Biol. Chem. 273: 29586 29591.
7. Kaul, S.C., S. Takano, R.R. Reddel, et al. 2000. Transcriptional inactivation of p53 by deletions and single amino acid changes in mouse mot-1 protein. Biochem. Biophys. Res. Commun. 279: 602 606.
8. Wadhwa, R., T. Yaguchi, K. Taira, et al. 2003. Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferaction. Biochem. Biophys. Res. Commun. 302: 735 742.